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trastuzumab emtansine (TAB-H70)

Recombinant Humanized (from mouse) antibody to Human ERBB2. Trastuzumab emtansine (ado-trastuzumab emtansine, trade name trastuzumab emtansine) is an antibody-drug conjugate consisting of the monoclonal antibody trastuzumab (trastuzumab) linked to the cytotoxic agent mertansine (DM1). Trastuzumab alone stops growth of cancer cells by binding to the HER2/neu receptor, whereas mertansine enters cells and destroys them by binding to tubulin. Because the monoclonal antibody targets HER2, and HER2 is only over-expressed in cancer cells, the conjugate delivers the toxin specifically to tumor cells. The conjugate is abbreviated T-DM1.      

  • Datasheet

Specifications
Host
Mouse
Derivation
Humanized (from mouse)
Type
IgG1 - kappa
Specificity
ERBB2(epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340) [Homo sapiens]
Species Reactivity
Human
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
Trade name
trastuzumab emtansine
CAS NO.
1018448-65-1
Generic Name
trastuzumab emtansine
Biological Half-Life
4 days
ATC Code
L01XC14
UNII
SE2KH7T06F
M.W.
148.5 kDa
Related Disease
Breast cancers overexpressing ERBB2, metastatic
Target
Alternative Names
trastuzumab emtansine; trastuzumab emtansine; 1018448-65-1; PRO132365; trastuzumab-MCC-DM1; Trastuzumab-DM1; T-DM1; RG3502
Entrez Gene ID
2064
UniProt ID
P04626

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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