Anti-Human GPC3 Therapeutic Antibody (Codrituzumab) (CAT#: TAB-H14)

Recombinant Humanized antibody to Human GPC3

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PK

Figure 1 IA/L of serum was plotted following injection of 10 mg I-124 codrituzumab alone (circle) or co-infused with 2.5 mg/kg (triangles) or 5 mg/kg (squares).

The larger mass amount of antibody resulted in significant mass-dependent changes with longer half-life and greater AUC than the 10 mg injection (Table 2). There was an overlap of the clearance curves for the 2.5 and 5 mg/kg co-infused mass.

Carrasquillo, J. A., O’Donoghue, J. A., Beylergil, V., Ruan, S., Pandit-Taskar, N., Larson, S. M.,... & Abou-Alfa, G. K. (2018). I-124 codrituzumab imaging and biodistribution in patients with hepatocellular carcinoma. EJNMMI research, 8(1), 20.

IHC

Figure 2 Distributions of CD16 MESF across different GPC3 IHC scores.

It was also noted that the distributions of CD16 MESF across the four different GPC3 IHC categories (0, 1+, 2+, and 3+) are not significantly different.

Chen, G., Chen, Y. C., Reis, B., Belousov, A., Jukofsky, L., Rossin, C.,... & Di Laurenzio, L. (2018). Combining expression of GPC3 in tumors and CD16 on NK cells from peripheral blood to identify patients responding to codrituzumab. Oncotarget, 9(12), 10436.

IHC

Figure 3 Kaplan-Meier curves by joint GPC3 IHC high/low and CD16 MESF high/low status, where a GPC3-IHC high level is defined by GPC3 IHC = 2+, 3+, and a CD16-MESF high level is defined by CD16 MESF ≥ the median (363,594 MESF).

(A, B) Association between CD16 MESF level and codrituzumab treatment effect given a high level of GPC3 IHC. (C, D) Association between CD16 MESF level and codrituzumab treatment effect given a low level of GPC3 IHC.

Chen, G., Chen, Y. C., Reis, B., Belousov, A., Jukofsky, L., Rossin, C.,... & Di Laurenzio, L. (2018). Combining expression of GPC3 in tumors and CD16 on NK cells from peripheral blood to identify patients responding to codrituzumab. Oncotarget, 9(12), 10436.


Specifications

  • Host Species
  • undefined
  • Derivation
  • Humanized
  • Type
  • IgG1 - kappa
  • Specificity
  • GPC3 (glypican 3) [Homo sapiens]
  • Species Reactivity
  • Human
  • Applications
  • FuncS, IF, Neut, ELISA, FC, IP, ICC, PK, IHC
  • CAS
  • 1365267-33-9
  • Generic Name
  • codrituzumab
  • Related Disease
  • Hepatocellular carcinoma (HCC)

Applications

  • Application Notes
  • The GPC3 antibody has been reported in applications of FuncS, IF, Neut, ELISA, FC, IP, ICC, PK, IHC.

Target

  • Alternative Names
  • codrituzumab;1365267-33-9;RG7686;GC33;Chugai anti-Glypican;RO5137382;GPC3;glypican 3;SDYS;glypican-3;DGSX;glypican proteoglycan 3;OCI 5;SGB;SGBS;SGBS1;secreted glypican-3;intestinal protein OCI-5;heparan sulphate proteoglycan;MXR7;OCI-5;GTR2-2;

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Resources

Please click here for more details about the introduction to mechanism of action, clinical projects and approved drugs of Codrituzumab.

See other products for "Codrituzumab"

Afuco™ Anti-GPC3 ADCC Therapeutic Antibody (Codrituzumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized antibody to Human GPC3

See other products for "GPC3"


For Research Use Only. Not For Clinical Use.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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