Anti-Human Hepatitis B virus Recombinant Antibody (Tuvirumab) (CAT#: TAB-879)

Recombinant human monoclonal antibody expressed in CHO binding to human Hepatitis B virus. Tuvirumab is a human monoclonal antibody for the treatment of patients with chronic hepatitis B.

Host: Human

Isotype: IgG1 - lambda

Applications: Inhib, ELISA


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Inhib

Figure 1 HBsAg levels (U/ml) measured before start of therapy, on day 14, 27, at the end of treatment and end of follow up after administration of Mab in the monotherapy or combination therapy group.

Van Nunen, A. B., Baumann, M., Manns, M. P., Reichen, J., Spengler, U., Marschner, J. P., & De Man, R. A. (2001). Efficacy and safety of an intravenous monoclonal anti‐HBs in chronic hepatitis B patients. Liver, 21(3), 207-212.

Inhib

Figure 2 Inhibition in solution of reference HBsAg with TUVIRUMAB (closed square), Hepatect (open triangle), and two patient pre-treatment samples.

Start concentration of TUVIRUMAB was 4 μg/ml.

Van Nunen, A. B., Baumann, M., Manns, M. P., Reichen, J., Spengler, U., Marschner, J. P., & De Man, R. A. (2001). Efficacy and safety of an intravenous monoclonal anti‐HBs in chronic hepatitis B patients. Liver, 21(3), 207-212.

ELISA

Figure 3 Titration of anti-HBs preparations (test procedure 3) on HepG2 2.2.15 HBsAg/ayw3. TUVIRUMAB-p (closed triangle, start at 2 mg/ml); TUVIRUMAB-r (closed square, start at 16 mg/ml).

Heijtink, R. A., Van Nunen, A. B., van Bergen, P., Östberg, L., Osterhaus, A. D. M. E., & De Man, R. A. (2001). Administration of a human monoclonal antibody (TUVIRUMAB) to chronic hepatitis B patients pre‐treated with lamivudine: monitoring of serum TUVIRUMAB in immune complexes. Journal of medical virology, 64(4), 427-434.

ELISA

Figure 4 Monitoring of reference HBsAg in artificial TUVIRUMAB/HBsAg complexes with different HBsAg/TUVIRUMAB ratios.

complex I: 1/10,000; complex II: 1/1,000; complex III: 1/100: complex IV:1/10. TUVIRUMAB antibodies and TUVIRUMAB/HBsAg complexes were captured with solid phase anti-TUVIRUMAB antibodies.

Heijtink, R. A., Van Nunen, A. B., van Bergen, P., Östberg, L., Osterhaus, A. D. M. E., & De Man, R. A. (2001). Administration of a human monoclonal antibody (TUVIRUMAB) to chronic hepatitis B patients pre‐treated with lamivudine: monitoring of serum TUVIRUMAB in immune complexes. Journal of medical virology, 64(4), 427-434.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG1 - lambda
  • Species Reactivity
  • HBV
  • Applications
  • Inhib, ELISA
  • CAS
  • 138660-97-6
  • Generic Name
  • Tuvirumab
  • Related Disease
  • Hepatitis B (Chronic active)

Product Property

  • Purity
  • >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

  • Application Notes
  • The Human Hepatitis B virus antibody has been reported in applications of Inhibition, Enzyme-linked Immunosorbent Assay.

Target

  • Alternative Names
  • Tuvirumab;138660-97-6;HbsAg;HBV;Major surface antigen

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Tuvirumab"

Afuco™ Anti-HBV ADCC Recombinant Antibody (Tuvirumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human monoclonal antibody expressed in CHO binding to human Hepatitis B virus. Tuvirumab is a human monoclonal antibody for the treatment of patients with chronic hepatitis B.

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scFv Fragment Antibody

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Humanized Antibody

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PABX-078 Recombinant Human Anti-Hepatitis B virus Antibody (KR127) WB, ELISA, FuncS IgG
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Mouse Antibody

CAT Product Name Application Type
PABX-078-S (P) Recombinant Human Anti-Hepatitis B virus Antibody scFv Fragment (KR127) WB, ELISA, FuncS scFv

MHC Tetramer for Virology

CAT Product Name Application Type
MHC-LC1349 PE-A*11:01/HBV (AIMPARFYPK) MHC Tetramer FCM
MHC-LC1350 APC-A*11:01/HBV (AIMPARFYPK) MHC Tetramer FCM
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Recombinant Antibody

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Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0343LY-F(E) Human Anti-HBV Recombinant Antibody; Fab Fragment (HPAB-0343LY-F(E)) ELISA, IF, Inhib Human Fab
HPAB-3166LY-F(E) Human Anti-HBV Recombinant Antibody; Fab Fragment (HPAB-3166LY-F(E)) ELISA Human Fab
HPAB-3167LY-F(E) Human Anti-HBV Recombinant Antibody; Fab Fragment (HPAB-3167LY-F(E)) ELISA Human Fab
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ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-746 Afuco™ Anti-HBV ADCC Recombinant Antibody (Exbivirumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-879 Afuco™ Anti-HBV ADCC Recombinant Antibody (Tuvirumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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