Anti-Human Hepatitis B virus Recombinant Antibody (Tuvirumab) (CAT#: TAB-879)
Recombinant human monoclonal antibody expressed in CHO binding to human Hepatitis B virus. Tuvirumab is a human monoclonal antibody for the treatment of patients with chronic hepatitis B.
Specific Inquiry
Inhib
Figure 1 HBsAg levels (U/ml) measured before start of therapy, on day 14, 27, at the end of treatment and end of follow up after administration of Mab in the monotherapy or combination therapy group.
Van Nunen, A. B., Baumann, M., Manns, M. P., Reichen, J., Spengler, U., Marschner, J. P., & De Man, R. A. (2001). Efficacy and safety of an intravenous monoclonal anti‐HBs in chronic hepatitis B patients. Liver, 21(3), 207-212.
Inhib
Figure 2 Inhibition in solution of reference HBsAg with TUVIRUMAB (closed square), Hepatect (open triangle), and two patient pre-treatment samples.
Start concentration of TUVIRUMAB was 4 μg/ml.
Van Nunen, A. B., Baumann, M., Manns, M. P., Reichen, J., Spengler, U., Marschner, J. P., & De Man, R. A. (2001). Efficacy and safety of an intravenous monoclonal anti‐HBs in chronic hepatitis B patients. Liver, 21(3), 207-212.
ELISA
Figure 3 Titration of anti-HBs preparations (test procedure 3) on HepG2 2.2.15 HBsAg/ayw3. TUVIRUMAB-p (closed triangle, start at 2 mg/ml); TUVIRUMAB-r (closed square, start at 16 mg/ml).
Heijtink, R. A., Van Nunen, A. B., van Bergen, P., Östberg, L., Osterhaus, A. D. M. E., & De Man, R. A. (2001). Administration of a human monoclonal antibody (TUVIRUMAB) to chronic hepatitis B patients pre‐treated with lamivudine: monitoring of serum TUVIRUMAB in immune complexes. Journal of medical virology, 64(4), 427-434.
ELISA
Figure 4 Monitoring of reference HBsAg in artificial TUVIRUMAB/HBsAg complexes with different HBsAg/TUVIRUMAB ratios.
complex I: 1/10,000; complex II: 1/1,000; complex III: 1/100: complex IV:1/10. TUVIRUMAB antibodies and TUVIRUMAB/HBsAg complexes were captured with solid phase anti-TUVIRUMAB antibodies.
Heijtink, R. A., Van Nunen, A. B., van Bergen, P., Östberg, L., Osterhaus, A. D. M. E., & De Man, R. A. (2001). Administration of a human monoclonal antibody (TUVIRUMAB) to chronic hepatitis B patients pre‐treated with lamivudine: monitoring of serum TUVIRUMAB in immune complexes. Journal of medical virology, 64(4), 427-434.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - lambda
- Species Reactivity
- HBV
- Applications
- Inhib, ELISA
- CAS
- 138660-97-6
- Generic Name
- Tuvirumab
- Related Disease
- Hepatitis B (Chronic active)
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The Human Hepatitis B virus antibody has been reported in applications of Inhibition, Enzyme-linked Immunosorbent Assay.
Target
- Alternative Names
- Tuvirumab;138660-97-6;HbsAg;HBV;Major surface antigen
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Tuvirumab"
Afuco™ Anti-HBV ADCC Recombinant Antibody (Tuvirumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human monoclonal antibody expressed in CHO binding to human Hepatitis B virus. Tuvirumab is a human monoclonal antibody for the treatment of patients with chronic hepatitis B.
See other products for "HBV"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1234-sdAb | Recombinant Anti-HBV VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-746 | Anti-HBV Recombinant Antibody (Exbivirumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - lambda |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-113 | Recombinant Mouse Anti-HBV Pres1 Region Antibody (5a19) | WB, ELISA, FuncS | IgG |
| HPAB-0248-WJ | Recombinant Human Anti-HBV Antibody (A2E2) | Neut, FC, ELISA | Human IgG |
| HPAB-J0115-YC | Recombinant Human Anti-HBV Antibody (1F11) | ELISA | Human IgG |
| FAMAB-0062WJ | Human Anti-HBV Recombinant Antibody (clone 23HN) | ELISA | Human IgG1, κ |
| HPAB-0542YY | Mouse Anti-HBV Recombinant Antibody (clone KY-01) | WB, ELISA, IF, IHC | Mouse IgG1, κ |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-078 | Recombinant Human Anti-Hepatitis B virus Antibody (KR127) | WB, ELISA, FuncS | IgG |
| PABX-078-F (E) | Recombinant Human Anti-Hepatitis B virus Antibody Fab Fragment (KR127) | WB, ELISA, FuncS | Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-078-S (P) | Recombinant Human Anti-Hepatitis B virus Antibody scFv Fragment (KR127) | WB, ELISA, FuncS | scFv |
MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1349 | PE-A*11:01/HBV (AIMPARFYPK) MHC Tetramer | FCM | |
| MHC-LC1350 | APC-A*11:01/HBV (AIMPARFYPK) MHC Tetramer | FCM | |
| MHC-LC1351 | BV421-A*11:01/HBV (AIMPARFYPK) MHC Tetramer | FCM |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0343LY-S(P) | Human Anti-HBV Recombinant Antibody; scFv Fragment (HPAB-0343LY-S(P)) | ELISA, IF, Inhib | Human scFv |
| HPAB-0248-WJ-S(P) | Recombinant Human Anti-HBV Antibody scFv Fragment (A2E2) | Neut, FC | Human scFv |
| HPAB-J0115-YC-S(P) | Recombinant Human Anti-HBV Antibody scFv Fragment (1F11) | ELISA | Human scFv |
| FAMAB-0062WJ-S(P) | Human Anti-HBV Recombinant Antibody (clone 23HN); scFv Fragment | ELISA | Human scFv |
| HPAB-0542YY-S(P) | Mouse Anti-HBV Recombinant Antibody (clone KY-01); scFv Fragment | WB, ELISA, IF, IHC | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0343LY-F(E) | Human Anti-HBV Recombinant Antibody; Fab Fragment (HPAB-0343LY-F(E)) | ELISA, IF, Inhib | Human Fab |
| HPAB-3166LY-F(E) | Human Anti-HBV Recombinant Antibody; Fab Fragment (HPAB-3166LY-F(E)) | ELISA | Human Fab |
| HPAB-3167LY-F(E) | Human Anti-HBV Recombinant Antibody; Fab Fragment (HPAB-3167LY-F(E)) | ELISA | Human Fab |
| HPAB-3168LY-F(E) | Human Anti-HBV Recombinant Antibody; Fab Fragment (HPAB-3168LY-F(E)) | ELISA | Human Fab |
| HPAB-3169LY-F(E) | Human Anti-HBV Recombinant Antibody; Fab Fragment (HPAB-3169LY-F(E)) | ELISA | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-746 | Afuco™ Anti-HBV ADCC Recombinant Antibody (Exbivirumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-879 | Afuco™ Anti-HBV ADCC Recombinant Antibody (Tuvirumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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