Anti-Human IFNA1 Recombinant Antibody (Sifalimumab)
CAT#: TAB-H62
Recombinant human antibody to Human IFNA1. Sifalimumab is a human monoclonal antibody designed for the treatment of SLE, dermatomyositis, and polymyositis.
Published Data
Gene Expression
ELISA
Figure 1 Pharmacokinetics (PK) and pharmacodynamics of sifalimumab over time in patients with systemic lupus erythematosus (PK population).
Serum concentrations of sifalimumab. Patients who missed the last 3 doses were excluded from the analysis.
Petri, M., Wallace, D. J., Spindler, A., Chindalore, V., Kalunian, K., Mysler, E., ... & Yao, Y. (2013). Sifalimumab, a human anti–interferon‐α monoclonal antibody, in systemic lupus erythematosus: a phase I randomized, controlled, dose‐escalation study. Arthritis & Rheumatism, 65(4), 1011-1021.
Inhib
Figure 2 Change from baseline in disease activity.
Combined sifalimumab group (n 121) and placebo group (n 40).
Petri, M., Wallace, D. J., Spindler, A., Chindalore, V., Kalunian, K., Mysler, E., ... & Yao, Y. (2013). Sifalimumab, a human anti–interferon‐α monoclonal antibody, in systemic lupus erythematosus: a phase I randomized, controlled, dose‐escalation study. Arthritis & Rheumatism, 65(4), 1011-1021.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (HeLa, hTERT-RPE1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197919-IFNA1
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Specifications
- Host Species
- human
- Derivation
- human
- Type
- IgG1 - kappa
- Specificity
- IFNA1 (interferon alpha 1, IFN-alpha, IFN alpha 1/13, IFN 13) [Homo sapiens]
- Species Reactivity
- Human
- Applications
- ELISA, Inhib
- CAS
- 1006877-41-3
- Generic Name
- sifalimumab
- UNII
- XOY1YA7RMC
- MW
- 146.25 kDa
- Related Disease
- Systemic lupus erythematosus (SLE)
Product Property
- Purity
- >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Applications
- Application Notes
- The IFNA1 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Inhibition.
Target
- Alternative Names
- sifalimumab;1006877-41-3;IFNA1;interferon, alpha 1;interferon alpha-1/13;IFL;IFN;IFN ALPHA;IFN alpha 1b;IFN alphaD;IFNA13;IFNA@;interferon alpha 1b;leIF D;IFN-alpha 1b;IFN-alpha-1/13;interferon-alpha1;interferon alpha-D;IFN-ALPHA;IFN-alphaD;MGC138207;MGC1
- Gene ID
- 3439
- UniProt ID
- P01562
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-H62, RRID: AB_3112039)
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Biosimilar Overview
Please refer to Sifalimumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Sifalimumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Sifalimumab"
Afuco™ Anti-IFNA1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H62)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human antibody to Human IFNA1. It is a human monoclonal antibody designed for the treatment of SLE, dermatomyositis, and polymyositis.
DrugMonitor™ Anti-Sifalimumab Antibody (VS-1224-YC1087)Sifalimumab is a fully human monoclonal antibody targeting interferon-alpha, potentially suppressing abnormal immune activity in lupus by binding to multiple interferon-alpha subtypes. The DrugMonitor™ Anti-Sifalimumab Antibody (VS-1224-YC1087) is an anti-drug antibody (ADA) against Sifalimumab. This drug-based antibody is raised in mice immunized with the Sifalimumab. The anti-Sifalimumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Sifalimumab in samples.
See other products for "IFNA1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1099z | Mouse Anti-IFNA1 Recombinant Antibody (clone 42B6) | ELISA, WB, FuncS | Mouse IgG1 |
| HPAB-0437-CN | Human Anti-IFNA1 Recombinant Antibody (HPAB-0437-CN) | ELISA | Human IgG |
| HPAB-0438-CN | Human Anti-IFNA1 Recombinant Antibody (HPAB-0438-CN) | ELISA, FC, Block | Human IgG |
| HPAB-0439-CN | Human Anti-IFNA1 Recombinant Antibody (HPAB-0439-CN) | ELISA, FC, Block | Human IgG |
| HPAB-0442-CN | Human Anti-IFNA1 Recombinant Antibody (HPAB-0442-CN) | ELISA, Block | Chimeric (mouse/human) IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-074 | Anti-Human IFN alpha Recombinant Antibody (TAB-074) | WB | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-747 | Anti-IFNA1 Recombinant Antibody (Faralimomab) | FuncS, IF, Neut, ELISA, FC, IP, IHC | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-960CQ | Mouse Anti-IFNA1 Recombinant Antibody (clone N27) | WB, Neut, ELISA | Mouse IgG1, κ |
| NEUT-961CQ | Mouse Anti-IFNA1 Recombinant Antibody (clone 8U18) | Neut, WB | Mouse IgG1 |
| NEUT-1070CQ | Mouse Anti-IFNA1 Recombinant Antibody (clone F17) | Neut | Mouse IgG1 |
| NEUT-1071CQ | Mouse Anti-IFNA1 Recombinant Antibody (clone K9) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4599 | Rabbit Anti-IFNA1 Recombinant Antibody (clone TH112DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0437-CN-S(P) | Human Anti-IFNA1 Recombinant Antibody; scFv Fragment (HPAB-0437-CN-S(P)) | ELISA, FC, Block | Human scFv |
| HPAB-0438-CN-S(P) | Human Anti-IFNA1 Recombinant Antibody; scFv Fragment (HPAB-0438-CN-S(P)) | ELISA, FC, Block | Human scFv |
| HPAB-0439-CN-S(P) | Human Anti-IFNA1 Recombinant Antibody; scFv Fragment (HPAB-0439-CN-S(P)) | ELISA, FC, Block | Human scFv |
| HPAB-0055LY-S(P) | Human Anti-IFNA1 Recombinant Antibody; scFv Fragment (HPAB-0055LY-S(P)) | ELISA, Inhib, FC | Humanized scfv |
| HPAB-0056LY-S(P) | Mouse Anti-IFNA1 Recombinant Antibody; scFv Fragment (HPAB-0056LY-S(P)) | ELISA, Inhib, FC | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0436-CN-F(E) | Human Anti-IFNA1 Recombinant Antibody Fab Fragment | ELISA, FC, Block | Human Fab |
| HPAB-0658-CN-F(E) | Human Anti-IFNA1 Recombinant Antibody; Fab Fragment (HPAB-0658-CN-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0055LY-F(E) | Human Anti-IFNA1 Recombinant Antibody; Fab Fragment (HPAB-0055LY-F(E)) | ELISA, Inhib, FC | Humanized Fab |
| HPAB-0056LY-F(E) | Mouse Anti-IFNA1 Recombinant Antibody; Fab Fragment (HPAB-0056LY-F(E)) | ELISA, Inhib, FC | Mouse Fab |
| HPAB-0127-WJ-F(E) | Human Anti-IFNA1 Recombinant Antibody; Fab Fragment (HPAB-0127-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-747 | Afuco™ Anti-IFNA1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-747) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-074 | Afuco™ Anti-IFNA1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-074) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-H62 | Afuco™ Anti-IFNA1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H62) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY118 | Human Anti-IFNA1 scFv-Fc Chimera (VS-0425-FY118) | ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3403 | Anti-IFNA1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3404 | Anti-Mouse IFNA1 Immunohistochemistry Kit | IHC |
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