Anti-Human IFNG Recombinant Antibody (Fontolizumab)
CAT#: TAB-041
Recombinant monoclonal antibody to IFNG. Fontolizumab (planned trade name HuZAF) is a humanized monoclonal antibody and an immunosuppressive drug for the treatment of auto-immune diseases like Crohn's disease.
Published Data
Tested Data
Gene Expression
Activ
Figure 1 Mean (SEM) Crohn’s disease activity index (CDAI) for patients receiving two doses of study drug.
Comparison is change from baseline value for each fontolizumab group versus placebo group.
Hommes, D. W., Mikhajlova, T. L., Stoinov, S., Štimac, D., Vucelic, B., Lonovics, J.,... & Lee, S. (2006). Fontolizumab, a humanised anti-interferon γ antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn’s disease. Gut, 55(8), 1131-1137.
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SDS-PAGE
Figure 1 Anti-Human IFNG Recombinant Antibody (TAB-041) in SDS-PAGE
SDS-PAGE analysis of TAB-041 in non-reduced (Lane 2) and reduced (Lane 1) conditions.
SEC-HPLC
Figure 2 Anti-Human IFNG Recombinant Antibody (TAB-041) in HPLC
HPLC analysis of TAB-041 shows the purity is>95%.
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Normal Tissue
Figure 1 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10344/26961_A_8_3.jpg
RNA Expression
Figure 2 RNA cell line category: Not detected
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000111537-IFNG
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- IP, IF, FuncS, FC, Neut, ELISA, IHC, Activ
- Trade name
- huzaf
- CAS
- 326859-36-3
- Generic Name
- Fontolizumab
- UNII
- 6J92H2439Z
- MW
- 150 kDa
- Related Disease
- Crohn's disease (CD)
Product Property
- Purity
- >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The IFNG antibody has been reported in applications of IP, IF, FuncS, FC, Neut, ELISA, IHC, Activ.
Target
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Biosimilar Overview
Please refer to Fontolizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Fontolizumab.
Related Diseases
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Primary Immunodeficiency
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Fontolizumab"
Afuco™ Anti-IFNG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-041)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IFNG. It is a humanized monoclonal antibody and an immunosuppressive drug for the treatment of auto-immune diseases like Crohn's disease.
DrugMonitor™ Anti-Fontolizumab Antibody (VS-1224-YC486)Fontolizumab is a humanized monoclonal antibody used as an immunosuppressive drug to treat Crohn's disease. The DrugMonitor™ Anti-Fontolizumab Antibody (VS-1224-YC486) is an anti-drug antibody (ADA) against Fontolizumab. This drug-based antibody is raised in mice immunized with the Fontolizumab. The anti-Fontolizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Fontolizumab in samples.
See other products for "IFNG"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-090 | Recombinant Anti-human IFNG VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-140CT | Anti-Human IFN-γ Single Domain Antibody (TAB-140CT), Research Grade Biosimilar | ELISA | Single domain antibody |
| TAB-141CT | Anti-Human IFN-γ Single Domain Antibody (TAB-141CT), Research Grade Biosimilar | ELISA | Single domain antibody |
| TAB-142CT | Anti-Human IFN-γ Single Domain Antibody (TAB-142CT), Research Grade Biosimilar | ELISA | Single domain antibody |
| TAB-143CT | Anti-Human IFN-γ Single Domain Antibody (TAB-143CT), Research Grade Biosimilar | ELISA | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0289MC | Recombinant Anti-Canine IFN-gamma Antibody. | WB, ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-112 | Recombinant Human Anti-IFN Antibody (ScFv01) | Neut, FuncS | IgG |
| PABX-112-S (P) | Recombinant Human Anti-IFN Antibody scFv Fragment (ScFv01) | Neut, FuncS | scFv |
| PABX-113-S (P) | Recombinant Human Anti-IFN-gamma Antibody scFv Fragment (HuZAF) | WB, ELISA, FuncS | scFv |
| PABX-112-F (E) | Recombinant Human Anti-IFN Antibody Fab Fragment (ScFv01) | Neut, FuncS | Fab |
| TAB-423CQ | Anti-Human IFNG Recombinant Antibody (TAB-423CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, λ1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-113 | Recombinant Human Anti-IFN-gamma Antibody (HuZAF) | WB, ELISA, FuncS | IgG |
| PABX-113-F (E) | Recombinant Human Anti-IFN-gamma Antibody Fab Fragment (HuZAF) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1002CQ | Mouse Anti-IFNG Recombinant Antibody (clone CBL253) | Inhib, IHC, IP | Mouse IgG1 |
| NEUT-1008CQ | Mouse Anti-IFNG Recombinant Antibody (clone B133.5) | Block | Mouse IgG1 |
| NEUT-1013CQ | Mouse Anti-IFNG Recombinant Antibody (clone B-B1) | Block, FC | Mouse IgG1 |
| NEUT-1014CQ | Mouse Anti-IFNG Recombinant Antibody (clone D9D10) | Block, FC, ELISA, WB | Mouse IgG1 |
| NEUT-1033CQ | Mouse Anti-IFNG Recombinant Antibody (clone SN-6) | ELISA, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1018CQ | Mouse Anti-IFNG Recombinant Antibody (clone NIB42) | ELISA, Neut, IP, RIA | Mouse IgG1 |
| NEUT-1019CQ | Mouse Anti-Ifng Recombinant Antibody (clone CBL981) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-1020CQ | Rat Anti-Ifng Recombinant Antibody (NEUT-1020CQ) | IHC-Fr, Neut | Rat IgG1 |
| NEUT-1021CQ | Rat Anti-Ifng Recombinant Antibody (clone R4-6A2) | ELISA, IHC, IHC-Fr, Neut, WB | Rat IgG1 |
| NEUT-1022CQ | Rat Anti-Ifng Recombinant Antibody (clone XMG1.2) | Neut | Rat IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1742 | Rabbit Anti-IFNG Recombinant Antibody (clone DS1742AB) | WB | Rabbit IgG |
| MOR-4228 | Rabbit Anti-IFNG Recombinant Antibody (clone SI307DS) | FC | Rabbit IgG |
| MOR-4600 | Rabbit Anti-IFNG Recombinant Antibody (clone TH113DS) | WB | Rabbit IgG |
| MOR-4601 | Rabbit Anti-IFNG Recombinant Antibody (clone TH114DS) | WB | Rabbit IgG |
| MOR-4602 | Rabbit Anti-Ifng Recombinant Antibody (clone TH115DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0882LC | Mouse Anti-IFNG Recombinant Antibody (clone MIF3009) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0040-YC | Human Anti-IFNG Recombinant Antibody (HPAB-0040-YC) | Neut, FuncS | Human IgG1, λ |
| HPAB-0041-YC | Human Anti-IFNG Recombinant Antibody (HPAB-0041-YC) | Neut | Human IgG |
| HPAB-0042-YC | Human Anti-IFNG Recombinant Antibody (HPAB-0042-YC) | ELISA, Neut | Human IgG1 |
| FAMAB-0162-CN | Human Anti-IFNG Recombinant Antibody (clone 41ms4G) | ELISA | Human IgG |
| FAMAB-0163-CN | Human Anti-IFNG Recombinant Antibody (clone 57-5) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0040-YC-S(P) | Human Anti-IFNG Recombinant Antibody; scFv Fragment (HPAB-0040-YC-S(P)) | Neut | Human scFv |
| HPAB-0041-YC-S(P) | Human Anti-IFNG Recombinant Antibody; scFv Fragment (HPAB-0041-YC-S(P)) | Neut | Human scFv |
| HPAB-0042-YC-S(P) | Human Anti-IFNG Recombinant Antibody; scFv Fragment (HPAB-0042-YC-S(P)) | ELISA, Neut | Human scFv |
| FAMAB-0176-YC-S(P) | Mouse Anti-IFNG Recombinant Antibody (clone D9DlO); scFv Fragment | ELISA, WB | Mouse scFv |
| FAMAB-0162-CN-S(P) | Human Anti-IFNG Recombinant Antibody (clone 41ms4G); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0162-CN-F(E) | Human Anti-IFNG Recombinant Antibody (clone 41ms4G); Fab Fragment | ELISA | Human Fab |
| FAMAB-0163-CN-F(E) | Human Anti-IFNG Recombinant Antibody (clone 57-5); Fab Fragment | ELISA | Human Fab |
| FAMAB-0164-CN-F(E) | Human Anti-IFNG Recombinant Antibody (clone 36-4); Fab Fragment | ELISA | Human Fab |
| FAMAB-0165-CN-F(E) | Human Anti-IFNG Recombinant Antibody (clone 44ms4); Fab Fragment | ELISA | Human Fab |
| FAMAB-0166-CN-F(E) | Human Anti-IFNG Recombinant Antibody (clone 13ms5F); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-041 | Afuco™ Anti-IFNG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-041) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| AFC-TAB-423CQ | Afuco™ Anti-IFNG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-423CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY143 | AbPlus™ Anti-IFNG Magnetic Beads (B27) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY270 | Mouse Anti-NHP IFNG Recombinant Antibody (VS-1024-XY270) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY40 | Human Anti-IFNG (clone BS-A) scFv-Fc Chimera | Neut, ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3412 | Anti-Mouse IFNG Immunohistochemistry Kit | IHC | |
| VS-0525-XY3414 | Anti-Zebrafish IFNG Immunohistochemistry Kit | IHC | |
| VS-0525-XY3413 | Anti-Rat IFNG Immunohistochemistry Kit | IHC |
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