Anti-Human IL5 Recombinant Antibody (Mepolizumab) (CAT#: TAB-031)
Recombinant monoclonal antibody to Human IL5. Mepolizumab (proposed trade name Bosatria) is a humanized monoclonal antibody that recognizes interleukin-5 (IL-5), and is used to treat certain kinds of asthma and white blood cell diseases. Recent studies have concluded that mepolizumab may improve exacerbations in patients with severe eosinophilic asthma, an adult-onset asthma which represents less than 5% of all asthma. IL-5 is a chemical messenger in the immune system that stimulates the growth of eosinophils. In eosinophilic asthma, eosinophils are present in the lungs. When mepolizumab was given to people with eosinophilic asthma, it eliminated eosinophils from the bloodstream,and reduced eosinophils in the lungs and bone marrow. Mepolizumab also reduced the number of asthma exacerbations, and reduced the need for corticosteroids.
Specific Inquiry
Figure 1 Anti-interleukin (IL)-5 (mepolizumab) decreases β2 but not β1 integrin activation on blood eosinophils.
Reactivity of monoclonal antibody (A) KIM-127 (to the intermediate-activity state of β2 integrin), and (b) N29 (to the intermediate-activity state of β1 integrin) on blood eosinophils before (green) and after (blue) anti-IL-5 mepolizumab administration. Red, isotype control. A representative subject with mild allergic asthma from Ref. (34).
Johansson, M. W. . (2017). Eosinophil activation status in separate compartments and association with asthma. Frontiers in Medicine, 4, 75-.
Figure 2 Photomicrographs of esophageal biopsies before and after anti–IL-5 therapy. Biopsies from the distalesophagus before (A, B) and after (C, D) anti–IL-5 therapy (mepolizumab).
The photomicrographs have been selected to demonstrate representative well oriented (A, C) and typical biopsies with maximal tissue pathology (B, D). Note the presence of marked eosinophilic inflammation and epithelial hyperplasia before (week 8) and reduced eosinophilic inflammation and epithelial hyperplasia after (week 20) anti–IL-5. The photomicrographs were taken from patient number 4. Original magnification, 3400.
Osterman, & M. (2007). Anti-il-5 (mepolizumab) therapy for eosinophilic esophagitis. Yearbook of Gastroenterology, 2007, 169.
Specifications
- Immunogen
- Recombinant human IL5.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen
- Species Reactivity
- Human
- Applications
- IF, IP, Neut, FuncS, ELISA, FC, ICC
- Trade name
- bosatria
- CAS
- 196078-29-2
- Generic Name
- Mepolizumab
- Biological Half-Life
- 20 days
- ATC Code
- L04AC06
- Related Disease
- Asthma
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Storage
- Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The IL5 antibody has been reported in applications of Activ, IHC.
Target
- Alternative Names
- Mepolizumab;bosatria;196078-29-2;SB-240563;IL5;interleukin 5 (colony-stimulating factor, eosinophil);interleukin-5;B cell differentiation factor I;EDF;eosinophil differentiation factor;IL 5;interleukin 5;T cell replacing factor;TRF;T-cell replacing factor
- Gene ID
- 3567
- UniProt ID
- P05113
Related Resources
Please refer to Mepolizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Mepolizumab.
Asthma
Inflammatory Bowel Diseases
Autoimmune Thyroid Disease
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Mepolizumab"
Afuco™ Anti-IL5 ADCC Recombinant Antibody (Mepolizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human IL5. Mepolizumab (proposed trade name Bosatria) is a humanized monoclonal antibody that recognizes interleukin-5 (IL-5), and is used to treat certain kinds of asthma and white blood cell diseases. Recent studies have concluded that mepolizumab may improve exacerbations in patients with severe eosinophilic asthma, an adult-onset asthma which represents less than 5% of all asthma. IL-5 is a chemical messenger in the immune system that stimulates the growth of eosinophils. In eosinophilic asthma, eosinophils are present in the lungs. When mepolizumab was given to people with eosinophilic asthma, it eliminated eosinophils from the bloodstream,and reduced eosinophils in the lungs and bone marrow. Mepolizumab also reduced the number of asthma exacerbations, and reduced the need for corticosteroids.
See other products for "IL5"
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Humanized Antibody
Neutralizing Antibody
Blocking Antibody
Fab Fragment Antibody
scFv Fragment Antibody
ADCC Enhanced Antibody
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-136 | Anti-Human IL5 Recombinant Antibody (Reslizumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG4 |
Customer Reviews and Q&As
Customer Review
Q&As
-
Excellent for IL5 Research
The Anti-Human IL5 Therapeutic Antibody (Bosatria) has been excellent for our IL5 studies. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time. -
Effective in Immunoassays
We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for IL5 is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab. -
Consistent and Reliable
This antibody has proven to be consistent and reliable in our assays. The high-quality, reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The strong affinity and specificity for IL5 have been particularly beneficial.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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