Recombinant monoclonal antibody to Human IL5. Mepolizumab (proposed trade name Bosatria) is a humanized monoclonal antibody that recognizes interleukin-5 (IL-5), and is used to treat certain kinds of asthma and white blood cell diseases. Recent studies have concluded that mepolizumab may improve exacerbations in patients with severe eosinophilic asthma, an adult-onset asthma which represents less than 5% of all asthma. IL-5 is a chemical messenger in the immune system that stimulates the growth of eosinophils. In eosinophilic asthma, eosinophils are present in the lungs. When mepolizumab was given to people with eosinophilic asthma, it eliminated eosinophils from the bloodstream,and reduced eosinophils in the lungs and bone marrow. Mepolizumab also reduced the number of asthma exacerbations, and reduced the need for corticosteroids.
Host: Mouse
Isotype: IgG1 - kappa
Applications: IF, IP, Neut, FuncS, ELISA, FC, ICC
Figure 1 Anti-interleukin (IL)-5 (mepolizumab) decreases β2 but not β1 integrin activation on blood eosinophils.
Reactivity of monoclonal antibody (A) KIM-127 (to the intermediate-activity state of β2 integrin), and (b) N29 (to the intermediate-activity state of β1 integrin) on blood eosinophils before (green) and after (blue) anti-IL-5 mepolizumab administration. Red, isotype control. A representative subject with mild allergic asthma from Ref. (34).
Johansson, M. W. . (2017). Eosinophil activation status in separate compartments and association with asthma. Frontiers in Medicine, 4, 75-.
Figure 2 Photomicrographs of esophageal biopsies before and after anti–IL-5 therapy. Biopsies from the distalesophagus before (A, B) and after (C, D) anti–IL-5 therapy (mepolizumab).
The photomicrographs have been selected to demonstrate representative well oriented (A, C) and typical biopsies with maximal tissue pathology (B, D). Note the presence of marked eosinophilic inflammation and epithelial hyperplasia before (week 8) and reduced eosinophilic inflammation and epithelial hyperplasia after (week 20) anti–IL-5. The photomicrographs were taken from patient number 4. Original magnification, 3400.
Osterman, & M. (2007). Anti-il-5 (mepolizumab) therapy for eosinophilic esophagitis. Yearbook of Gastroenterology, 2007, 169.
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• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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Afuco™ Anti-IL5 ADCC Recombinant Antibody (Mepolizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human IL5. Mepolizumab (proposed trade name Bosatria) is a humanized monoclonal antibody that recognizes interleukin-5 (IL-5), and is used to treat certain kinds of asthma and white blood cell diseases. Recent studies have concluded that mepolizumab may improve exacerbations in patients with severe eosinophilic asthma, an adult-onset asthma which represents less than 5% of all asthma. IL-5 is a chemical messenger in the immune system that stimulates the growth of eosinophils. In eosinophilic asthma, eosinophils are present in the lungs. When mepolizumab was given to people with eosinophilic asthma, it eliminated eosinophils from the bloodstream,and reduced eosinophils in the lungs and bone marrow. Mepolizumab also reduced the number of asthma exacerbations, and reduced the need for corticosteroids.
CAT | Product Name | Application | Type |
TAB-136 | Anti-Human IL5 Recombinant Antibody (Reslizumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG4 |
CAT | Product Name | Application | Type |
MOB-0631CT | Recombinant Mouse anti-Human IL5 Monoclonal antibody (RT-6) | ELISA, ELISPOT, IHC-Fr, Neut, WB | |
HPAB-0001-CN | Human Anti-IL5 Recombinant Antibody (clone h39D10) | ELISA | Humanized IgG |
HPAB-N0359-YC | Human Anti-IL5 Recombinant Antibody (HPAB-N0359-YC) | ELISA, Inhib | Human IgG |
FN-146CQ | Rat Anti-Il5 Recombinant Antibody (clone TRFK-5) | ELISA, IA, Block, FC, IHC, Neut, WB | Rat IgG1 |
HPAB-0053-YJ | Human Anti-IL5 Recombinant Antibody (clone CMX5-1) | ELISA | Humanized IgG4, κ |
CAT | Product Name | Application | Type |
NEUT-1437CQ | Mouse Anti-IL5 Recombinant Antibody (clone CBL632) | ELISA, Neut | Mouse IgG2a |
NEUT-1438CQ | Mouse Anti-IL5 Recombinant Antibody (clone CBL420) | Neut | Mouse IgG1 |
NEUT-1439CQ | Rat Anti-IL5 Recombinant Antibody (clone CBL900) | ELISA, FC, IF, Neut, WB | Rat IgG1, κ |
NEUT-1440CQ | Rat Anti-IL5 Recombinant Antibody (clone JES1-39D10) | ELISA, ELISPOT, Neut, ICFC, IHC, WB | Rat IgG2a, κ |
NEUT-1441CQ | Rat Anti-IL5 Recombinant Antibody (clone JES1-5A10) | ELISA, ELISPOT, Neut | Rat IgG2a, κ |
CAT | Product Name | Application | Type |
NEUT-1443CQ | Rat Anti-IL5 Recombinant Antibody (clone TRFK4) | ELISA, Inhib, WB | Rat IgG2a |
CAT | Product Name | Application | Type |
HPAB-0250CQ-F(E) | Human Anti-IL5 Recombinant Antibody; Fab Fragment (HPAB-0250CQ-F(E)) | ELISA, Neut, FuncS | Human Fab |
HPAB-0875-FY-S(P) | Human Anti-IL5 Recombinant Antibody; scFv Fragment (HPAB-0875-FY-S(P)) | ELISA | Humanized scFv |
HPAB-1249-FY-S(P) | Mouse Anti-IL5 Recombinant Antibody; scFv Fragment (HPAB-1249-FY-S(P)) | Neut | Mouse scFv |
HPAB-1617WJ-F(E) | Mouse Anti-IL5 Recombinant Antibody; Fab Fragment (clone 2F2) | ELISA, WB, Neut | Mouse Fab |
HPAB-1618WJ-F(E) | Mouse Anti-IL5 Recombinant Antibody; Fab Fragment (clone 2E3) | ELISA, WB, Neut | Mouse Fab |
CAT | Product Name | Application | Type |
AFC-TAB-031 | Afuco™ Anti-IL5 ADCC Recombinant Antibody (Mepolizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-136 | Afuco™ Anti-IL5 ADCC Recombinant Antibody (Reslizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
HPAB-0053-YJ-S(P) | Human Anti-IL5 Recombinant Antibody (clone CMX5-1); scFv Fragment | ELISA | Humanized scFv |
HPAB-0875-FY-F(E) | Human Anti-IL5 Recombinant Antibody; Fab Fragment (HPAB-0875-FY-F(E)) | ELISA | Humanized Fab |
HPAB-1249-FY-F(E) | Mouse Anti-IL5 Recombinant Antibody; Fab Fragment (HPAB-1249-FY-F(E)) | Neut | Mouse Fab |
HPAB-1617WJ-S(P) | Mouse Anti-IL5 Recombinant Antibody; scFv Fragment (clone 2F2) | ELISA, WB, Neut | Mouse scFv |
HPAB-1618WJ-S(P) | Mouse Anti-IL5 Recombinant Antibody; scFv Fragment (clone 2E3) | ELISA, WB, Neut | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.