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Tarextumab (TAB-H67)

Recombinant human antibody to Human NOTCH2. Tarextumab (anti-Notch2/3, OMP-59R5) is a novel anti-cancer stem cell antibody identified by screening against the Notch3 receptor that binds to and prevents signaling through both the Notch2 and Notch3 receptors. Tarextumab has been shown in preclinical models to have broad-spectrum anti-tumor activity via inhibition of cancer stem cell growth, and promoting cell differentiation, as well as disrupting tumor angiogenesis by inhibiting vascular pericytes.      

  • Datasheet

Specifications
Host
human
Derivation
human
Type
IgG2 - kappa
Specificity
NOTCH2 (notch 2) [Homo sapiens] ;
Species Reactivity
Human
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
CAS NO.
1359940-55-8
Generic Name
tarextumab
Related Disease
Pancreatic cancers
Target
Alternative Names
tarextumab; 1359940-55-8; OMP-59R5; 59M07; 13M57; anti-Notch2/3; OMP-59R5; NOTCH2
Entrez Gene ID
4853
UniProt ID
Q04721

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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