Recombinant monoclonal antibody to TGF-beta. Fresolimumab (GC1008) is a human monoclonal antibody and an immunomodulator. It is intended for the treatment of idiopathic pulmonary fibrosis (IPF), focal segmental glomerulosclerosis, and cancer (kidney cancer and melanoma).
Figure 1 Mean serum concentrations of fresolimumab over time are presented by dose.
Mean serum fresolimumab concentration over time.
Trachtman, H., Fervenza, F. C., Gipson, D. S., Heering, P., Jayne, D. R., Peters, H.,... & Heaton, J. P. (2011). A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis. Kidney international, 79(11), 1236-1243.
Figure 2 Study design and pharmacokinetics of fresolimumab in two dosing groups.
(A) Trial protocol for each group shows dosing levels and frequency and timing of skin biopsies. Red arrows indicate skin biopsies. (B) Fresolimumab levels measured in sera at 3, 7, 11, 17, and 24 weeks in group 1, which received 2 doses of 1 mg/kg at weeks 0 and 4 (blue diamonds), and group 2, which received a single dose of 5 mg/kg fresolimumab at week 0 (red squares). Error bars indicate SD.
Rice, L. M., Padilla, C. M., McLaughlin, S. R., Mathes, A., Ziemek, J., Goummih, S.,... & Spiera, R. F. (2015). Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients. The Journal of clinical investigation, 125(7), 2795-2807.
Figure 3 Small-animal PET with 89Zr-fresolimumab showed tumor uptake in both CHO-Cl2 and CHO-Cl11S (A and C, respectively; arrow indicates tumor).
Tumor uptake and organ distribution of 89Zr-fresolimumab and control 111In-IgG as quantified ex vivo (B and D, respectively).
Munnink, T. H. O., Arjaans, M. E., Timmer-Bosscha, H., Schröder, C. P., Hesselink, J. W., Vedelaar, S. R.,... & de Vries, E. G. (2011). PET with the 89Zr-labeled transforming growth factor-β antibody fresolimumab in tumor models. Journal of Nuclear Medicine, 52(12), 2001-2008.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
Afuco™ Anti-TGFB1 ADCC Recombinant Antibody (Fresolimumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to TGF-beta. Fresolimumab (GC1008) is a human monoclonal antibody and an immunomodulator. It is intended for the treatment of idiopathic pulmonary fibrosis (IPF), focal segmental glomerulosclerosis, and cancer (kidney cancer and melanoma).
CAT | Product Name | Application | Type |
---|---|---|---|
DrMAB-98 | Mouse Anti-Tgfb1 Recombinant Antibody (clone CB57B9) | Neut, FC | Mouse IgG1, κ |
HPAB-0492-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0492-CN) | ELISA, FC, IF, Neut | Human IgG2 |
HPAB-0493-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0493-CN) | ELISA, FC, IF, Neut | Human IgG2 |
HPAB-0494-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0494-CN) | ELISA, Neut | Human IgG4 |
HPAB-0495-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0495-CN) | ELISA, Neut | Human IgG4 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-762 | Anti-TGFB1 Recombinant Antibody (Metelimumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG4 - kappa |
TAB-635CT | Human Anti-TGFB1 Recombinant Antibody (TAB-635CT) | ELISA, WB, FC, IP | Human IgG |
TAB-636CT | Human Anti-TGFB1 Recombinant Antibody (TAB-636CT) | ELISA, WB, FC, IP | Human IgG |
TAB-637CT | Human Anti-TGFB1 Recombinant Antibody (TAB-637CT) | ELISA, WB, FC, IP | Human IgG |
TAB-638CT | Human Anti-TGFB1 Recombinant Antibody (TAB-638CT) | ELISA, WB, FC, IP | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-605CL | Human Anti-TGFB1 Recombinant Antibody (TAB-605CL) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-344 | Human Anti-TGFB1 Recombinant Antibody (PSBL-344); scFv Fragment | WB, ELISA, FuncS | Human scFv |
HPAB-N0392-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-N0392-YC-S(P)) | ELISA, Inhib | Human scFv |
HPAB-N0393-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-N0393-YC-S(P)) | ELISA, Inhib | Human scFv |
HPAB-N0394-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-N0394-YC-S(P)) | IHC, Neut, FuncS | Human scFv |
HPAB-0737LY-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0737LY-S(P)) | ELISA | Mouse scfv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-632CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-632CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
TAB-633CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-633CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
TAB-634CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-634CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
TAB-632CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-632CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
TAB-633CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-633CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0853MZ | Chicken Anti-TGF beta-1 Polyclonal IgY | ELISA, IHC, WB | Chicken antibody |
BRD-1095MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to APC | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
BRD-1096MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to AP | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
BRD-1097MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to AMCA | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
BRD-1098MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2003CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone CBL443) | Neut | Mouse IgG1 |
NEUT-2004CQ | Mouse Anti-Tgfb1 Recombinant Antibody (clone TW7-28G11) | FC, WB, IP, Neut | Mouse IgG2b, κ |
NEUT-2005CQ | Mouse Anti-Tgfb1 Recombinant Antibody (clone TW7-20B9) | FC, IP, Neut, WB | Mouse IgG1, κ |
NEUT-2006CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 1D11.16.8) | Neut | Mouse IgG1 |
NEUT-2007CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 2Ar2) | IHC-Fr, WB, ELISA, IHC-Fr, Neut, FC | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2009CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 9016.2) | ELISA, Inhib, WB | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3550 | Rabbit Anti-TGFB1 Recombinant Antibody (clone DS3550AB) | WB | Rabbit IgG |
MOR-4451 | Rabbit Anti-TGFB1 Recombinant Antibody (clone SI544DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0492-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0492-CN-F(E)) | ELISA, FC, IF, Neut | Human Fab |
HPAB-0493-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0493-CN-F(E)) | ELISA, FC, IF, Neut | Human Fab |
HPAB-0494-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0494-CN-F(E)) | ELISA, Neut | Human Fab |
HPAB-0495-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0495-CN-F(E)) | ELISA, Neut | Human Fab |
HPAB-0496-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0496-CN-F(E)) | ELISA, Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-140 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody (Fresolimumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-762 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody (Metelimumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-CN1265 | PE-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
MHC-CN1266 | APC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
MHC-CN1267 | FITC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
MHC-CN1268 | A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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