Anti-Human VEGF Recombinant Antibody (Bevacizumab) (CAT#: TAB-011)
Recombinant monoclonal antibody to Human VEGF is an angiogenesis inhibitor, a drug that slows the growth of new blood vessels. It is licensed to treat various cancers, including colorectal, lung, breast (outside the USA), glioblastoma (USA only), kidney and ovarian. Bevacizumab is a humanized monoclonal antibody that produces angiogenesis inhibition by inhibiting vascular endothelial growth factor A (VEGF-A). VEGF-A is a chemical signal that stimulates angiogenesis in a variety of diseases, especially in cancer.
Specific Inquiry
WB
Figure 1 Anti-Human VEGF Recombinant Antibody (TAB-011) in WB
Western blot analysis of TAB-011 was performed by loading Human VEGF165 Protein (His Tag) onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-011 and HRP Goat Anti-Human IgG as a secondary antibody. Chemiluminescent detection was performed.
Lane 1: Reduced antigen (0.8 μg)
WB
Figure 2 Anti-Human VEGF Recombinant Antibody (TAB-011) in WB
Western blot analysis of TAB-011 was performed by loading Human VEGF121 Protein (His Tag) onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-011 and HRP Goat Anti-Human IgG as a secondary antibody. Chemiluminescent detection was performed.
Lane 1: Reduced antigen (0.8 μg)
DB
Figure 3 Anti-Human VEGF Recombinant Antibody (TAB-011) in DB
Dot Blot analysis of TAB-011 was performed by coating with Human VEGF165 Protein (His Tag).
TAB-011 incubation concentration: 2 μg/mL.
HRP-conjugated goat anti-Human IgG as a secondary antibody (1: 2000)
DB
Figure 4 Anti-Human VEGF Recombinant Antibody (TAB-011) in DB
Dot Blot analysis of TAB-011 was performed by coating with Human VEGF121 Protein (His Tag).
TAB-011 incubation concentration: 2 μg/mL.
HRP-conjugated goat anti-Human IgG as a secondary antibody (1: 2000)
ELISA
Figure 5 Anti-Human VEGF Recombinant Antibody (TAB-011) in ELISA
ELISA analysis of TAB-011 was performed by coating with Human VEGF165 Protein (His Tag). Then blocked with BSA, and incubated with TAB-011. The HRP-conjugated goat anti-human IgG as a secondary antibody. Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
ELISA
Figure 6 Anti-Human VEGF Recombinant Antibody (TAB-011) in ELISA
ELISA analysis of TAB-011 was performed by coating with Human VEGF121 Protein (His Tag). Then blocked with BSA, and incubated with TAB-011. The HRP-conjugated goat anti-human IgG as a secondary antibody. Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
Specifications
- Immunogen
- Purified intact human VEGF
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen
- Species Reactivity
- Human
- Applications
- Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
- Trade name
- Bevacizumab
- CAS
- 216974-75-3
- Generic Name
- Bevacizumab
- Biological Half-Life
- 20 days (range: 11–50 days)
- ATC Code
- L01XC07
- DrugBank
- DB00112
- UNII
- 2S9ZZM9Q9V
- ChEMBL
- CHEMBL1201583
- MW
- 149 kDa
- Related Disease
- Colorectal cancers, metastatic
Product Property
- Purity
- >95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
- Alternative Names
- Bevacizumab;bevacizumab;216974-75-3;DB00112VEGFA;vascular endothelial growth factor A;vascular endothelial growth factor , VEGF;VEGF A;VPF;vascular permeability factor;VEGF;MVCD1;MGC70609;
- Gene ID
- 7422
- UniProt ID
- P15692
Related Resources
Please refer to Bevacizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Bevacizumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Bevacizumab"
Afuco™ Anti-VEGFA ADCC Recombinant Antibody (Bevacizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human VEGF is an angiogenesis inhibitor, a drug that slows the growth of new blood vessels. It is licensed to treat various cancers, including colorectal, lung, breast (outside the USA), glioblastoma (USA only), kidney and ovarian. Bevacizumab is a humanized monoclonal antibody that produces angiogenesis inhibition by inhibiting vascular endothelial growth factor A (VEGF-A). VEGF-A is a chemical signal that stimulates angiogenesis in a variety of diseases, especially in cancer.
See other products for "VEGFA"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H73 | Anti-Human VEGFA Recombinant Antibody (Vanucizumab) | WB, FC, IP, ELISA, Neut, FuncS, IF | VH - C-kappa - CH2 - CH3 _ V-lambda - CH1 _ H-GAMMA-1 _ L-kappa |
| TAB-307CQ | Human Anti-VEGFA Recombinant Antibody (TAB-307CQ) | Inhib | Human IgG |
| TAB-307CQ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-307CQ-S(P)) | ELISA, Neut | Human scFv |
| TAB-307CQ-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-307CQ-F(E)) | ELISA, Neut | Humanized Fab |
| TAB-009ML | Anti-Human VEGFA Recombinant Antibody scFv Fragment (Brolucizumab) | ELISA, IHC, FC, IP, IF, Inhib | scFv, κ |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L043L | anti-VEGFA immunotoxin Ng76 (scFv)-Luffin-β | Cytotoxicity assay, Functional assay |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-075 | Mouse Anti-VEGFA Recombinant Antibody (clone YADS1); Fab Fragment | ELISA | Mouse Fab |
| PFBC-076 | Mouse Anti-VEGFA Recombinant Antibody (clone YADS2); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0151-FY-F(E) | Human Anti-VEGFA Recombinant Antibody (clone rhVVH); Fab Fragment | WB, ELISA, Inhib | Human Fab |
| HPAB-0330CQ-F(E) | Mouse Anti-VEGFA Recombinant Antibody (clone mAb G6-31); Fab Fragment | ELISA, IF, Block | Chimeric (mouse/human) Fab |
| HPAB-0715-FY-S(P) | Mouse Anti-VEGFA Recombinant Antibody (clone AB014); Fab Fragment | ELISA | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-304CQ | Anti-Human VEGFA Recombinant Antibody (2H1) | ELISA | Human antibody |
| TAB-305CQ | Anti-Human VEGFA Recombinant Antibody (2H1-32) | ELISA, WB | Human antibody |
| TAB-284CQ-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-284CQ-F(E)) | ELISA | Human Fab |
| TAB-304CQ-F(E) | Anti-Human VEGFA Recombinant Antibody Fab Fragment (2H1) | ELISA, WB | Human antibody |
| TAB-305CQ-F(E) | Anti-Human VEGFA Recombinant Antibody Fab Fragment (2H1-32) | ELISA, WB | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-306CQ | Mouse Anti-VEGFA Recombinant Antibody (TAB-306CQ) | FuncS, Inhib | Mouse IgG |
| TAB-306CQ-S(P) | Mouse Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-306CQ-S(P)) | ELISA, Neut | Mouse scFv |
| TAB-306CQ-F(E) | Mouse Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-306CQ-F(E)) | ELISA, Neut | Mouse Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0623MZ | Chicken Anti-VEGF Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2255CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL198) | Neut, WB | Mouse IgG1 |
| NEUT-2256CQ | Rat Anti-Vegfa Recombinant Antibody (clone 2G11-2A05) | WB, Neut, ELISA, IHC, FuncS | Rat IgG2a, κ |
| NEUT-2257CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 16F1) | WB, Neut | Mouse IgG2a |
| NEUT-2258CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 4B2-8) | ELISA, Neut, WB | Mouse IgG1, κ |
| NEUT-2260CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL737) | WB, ELISA, Neut | Mouse IgG2b |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2259CQ | Mouse Anti-VEGFA Recombinant Antibody (clone A.4.6.1) | ELISA, IP, WB, Block, FC, IHC | Mouse IgG1, κ |
| NEUT-2267CQ | Mouse Anti-VEGFA Recombinant Antibody (clone A15136B) | WB, Block | Mouse IgG2b, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3835 | Rabbit Anti-VEGFA Recombinant Antibody (clone DS3835AB) | FC, ICC, IF, IHC-P, IP, WB | Rabbit IgG |
| MOR-4758 | Rabbit Anti-Vegfa Recombinant Antibody (clone TH272DS) | WB | Rabbit IgG |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MD-ZBF-YC024 | Camelid Anti-VEGFA Recombinant Single Domain Antibody (clone A80887) | ELlSA | Camelid VHH |
| HPAB-N0310-YC-VHNAR | Recombinant Shark Anti-VEGFA Single Domain Antibody (V32R) | ELISA, FC, WB | Shark vNAR |
| HPAB-N0311-YC-VHNAR | Recombinant Shark Anti-VEGFA Single Domain Antibody (V19) | ELISA, FC, WB | Shark vNAR |
| HPAB-0337-YJ-vNAR | Recombinant Shark Anti-VEGFA vNAR (V32R) | FC, ELISA, Inhib, Neut | Shark vNAR |
| HPAB-0338-YJ-vNAR | Recombinant Shark Anti-VEGFA vNAR (V19) | FC, ELISA, Inhib, Neut | Shark vNAR |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0671-CN | Human Anti-VEGFA Recombinant Antibody (HPAB-0671-CN) | ELISA, Neut | Humanized IgG |
| HPAB-M0372-YC | Canine Anti-VEGFA Recombinant Antibody (HPAB-M0372-YC) | FuncS, Inhib | Chimeric (Mouse/Canine) IgGB, κ |
| HPAB-M0373-YC | Canine Anti-VEGFA Recombinant Antibody (HPAB-M0373-YC) | ELISA, Inhib, FuncS | Chimeric (Mouse/Canine) IgGB, κ |
| HPAB-M0374-YC | Canine Anti-VEGFA Recombinant Antibody (HPAB-M0374-YC) | ELISA, Inhib, FuncS | Chimeric (Mouse/Canine) IgGB, λ |
| HPAB-1625-FY | Human Anti-VEGFA Recombinant Antibody (clone TK001) | PP, Neut | Humanized IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-465CQ | Afuco™ Anti-VEGFA ADCC Recombinant Antibody (Varisacumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-011 | Afuco™ Anti-VEGFA ADCC Recombinant Antibody (Bevacizumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0152-YC-S(P) | Human Anti-VEGFA Recombinant Antibody (clone Y0243-1); scFv Fragment | ELISA, Inhib | Humanized scFv |
| HPAB-1933-FY-F(E) | Human Anti-VEGFA Recombinant Antibody (clone Y0101); scFv Fragment | ELISA | Humanized scFv |
| HPAB-1956-FY-S(P) | Human Anti-VEGFA Recombinant Antibody (clone Bh21-7); scFv Fragment | IF | Humanized scFv |
| HPAB-2046-FY-S(P) | Human Anti-VEGFA Recombinant Antibody (clone C1039); scFv Fragment | IA | Human scFv |
| HPAB-0677YY-S(P) | Mouse Anti-VEGFA Recombinant Antibody (clone CBV110YJ); scFv Fragment | ELISA, FuncS | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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