Recombinant Human Antibody (100F4) is capable of binding to IAV HA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-IAV HA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-IAV HA proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Figure 1 Neutralization activity of 7 monoclonal antibodies against H5N1 SZ06 and H5N8 NE14 pseudotypes using PN assay.
The titration of neutralization activity of antibody 100F4 against H5N1 SZ06 (green color line) and H5N8 NE14 (red color line) pseudotypes, respectively.
Ren, H., Wang, G., Wang, S., Chen, H., Chen, Z., Hu, H., ... & Zhou, P. (2016, August). Cross-protection of newly emerging HPAI H5 viruses by neutralizing human monoclonal antibodies: a viable alternative to oseltamivir. In MAbs (Vol. 8, No. 6, pp. 1156-1166). Taylor & Francis.
Figure 2 In vivo efficacy of antibody 100F4 against the H5N8 NE14 virus.
Prophylactic efficacy of antibody 100F4. Time course of body weight changes.
Ren, H., Wang, G., Wang, S., Chen, H., Chen, Z., Hu, H., ... & Zhou, P. (2016, August). Cross-protection of newly emerging HPAI H5 viruses by neutralizing human monoclonal antibodies: a viable alternative to oseltamivir. In MAbs (Vol. 8, No. 6, pp. 1156-1166). Taylor & Francis.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
DrMAB-116 | Recombinant Human Anti-IAV HA Antibody, clone FLD21 | NTRL | IgG |
PABZ-077 | Recombinant Mouse Anti-IAV HA Antibody (BH151) | Neut | IgG |
PABW-077 | Recombinant Mouse Anti-IAV HA Antibody (HC19) | Neut | IgG |
PABL-486 | Human Anti-IAV HA Recombinant Antibody (PABL-486) | Neut | Human IgG |
MRO-2168CQ | Recombinant Mouse Anti-IAV HA Antibody (16B12) | WB, IF, IP, IHC-P, IHC-Fr | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NABG-078 | Recombinant Anti-IAV HA VHH Single Domain Antibody | FC, CA, IP, FuncS | Llama VHH |
HPAB-0344CQ | Recombinant Llama Anti-IAV HA Single Domain Antibody (SD38) | ELISA, Neut | Llama VHH |
HPAB-0345CQ | Recombinant Llama Anti-IAV HA Single Domain Antibody (SD36) | ELISA, Neut | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H33 | Anti-IAV HA Recombinant Antibody (Firivumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
TAB-027ML | Anti-IAV HA Recombinant Antibody (Gedivumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
TAB-438CQ | Anti-IAV HA Recombinant Antibody (Navivumab) | ELISA, IHC, FC, IP, IF, BL | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-483 | Human Anti-IAV HA Recombinant Antibody; scFv Fragment (PSBL-483) | Neut | Human scFv |
HPAB-0870-CN-S(P) | Human Anti-IAV HA Recombinant Antibody; scFv Fragment (HPAB-0870-CN-S(P)) | ELISA | Human scFv |
PSBC-393 | Recombinant Human Anti-IAV HA Antibody scFv Fragment (MEDI8852) | ELISA, Neut | Human scFv |
PSBC-426 | Human Anti-IAV HA Recombinant Antibody; scFv Fragment (PSBC-426) | ELISA, Neut | Human scFv |
HPAB-0304-WJ-S(P) | Human Anti-IAV HA Recombinant Antibody; scFv Fragment (HPAB-0304-WJ-S(P)) | Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0652CQ | Recombinant Mouse Anti-IAV HA Antibody (pSAN13.4.1) | ELISA | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBC-343 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (6639) | ELISA, Neut | Human Fab |
PFBC-344 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (56.a.09) | ELISA, FC, Neut | Human Fab |
PFBC-345 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (31.b.09) | ELISA, FC, Neut | Human Fab |
PFBC-346 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (16.a.26) | ELISA, FC, Neut | Human Fab |
PFBC-347 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (16.g.07) | ELISA, FC, Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-027ML | Afuco™ Anti-IAV HA ADCC Recombinant Antibody (Gedivumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-438CQ | Afuco™ Anti-IAV HA ADCC Recombinant Antibody (Navivumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
AFC-TAB-H33 | Afuco™ Anti-IAV HA ADCC Recombinant Antibody (Firivumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-YC213 | H-2Kd/Influenza A virus Haemagglutinin (IYSTVASSL) MHC Pentamer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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