Recombinant Human Anti-IAV HA Antibody (100F4)
CAT#: PABL-584
Recombinant Human Antibody (100F4) is capable of binding to IAV HA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-IAV HA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-IAV HA proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Published Data
Neut
Figure 1 Neutralization activity of 7 monoclonal antibodies against H5N1 SZ06 and H5N8 NE14 pseudotypes using PN assay.
The titration of neutralization activity of antibody 100F4 against H5N1 SZ06 (green color line) and H5N8 NE14 (red color line) pseudotypes, respectively.
Ren, H., Wang, G., Wang, S., Chen, H., Chen, Z., Hu, H., ... & Zhou, P. (2016, August). Cross-protection of newly emerging HPAI H5 viruses by neutralizing human monoclonal antibodies: a viable alternative to oseltamivir. In MAbs (Vol. 8, No. 6, pp. 1156-1166). Taylor & Francis.
FuncS
Figure 2 In vivo efficacy of antibody 100F4 against the H5N8 NE14 virus.
Prophylactic efficacy of antibody 100F4. Time course of body weight changes.
Ren, H., Wang, G., Wang, S., Chen, H., Chen, Z., Hu, H., ... & Zhou, P. (2016, August). Cross-protection of newly emerging HPAI H5 viruses by neutralizing human monoclonal antibodies: a viable alternative to oseltamivir. In MAbs (Vol. 8, No. 6, pp. 1156-1166). Taylor & Francis.
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Specifications
- Immunogen
- IAV haemagglutinin
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native IAV HA
- Species Reactivity
- IAV
- Clone
- 100F4
- Applications
- Neut, FuncS
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- This antibody has been reported for use in Neutralization and Function Assay.
Target
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There are currently no Customer reviews or questions for PABL-584. Click the button above to contact us or submit your feedback about this product.
Great for Neutralization Studies
We successfully used this recombinant human antibody (clone 100F4) in our neutralization assays against Influenza A virus. It bound specifically to the HA protein and provided reproducible data. The purity and functional grade quality were evident in the results we obtained.
High Quality Human Antibody
This product was perfect for our functional studies involving IAV haemagglutinin. Expressed in HEK 293 cells, the antibody quality was excellent. It showed positive binding against native IAV HA, which was critical for the relevance of our viral research.
Q&As
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Can you describe the structure and expression of this antibody?
A: This Recombinant Human Antibody (100F4) is expressed in HEK 293 cells. It consists of a heavy chain (HC) with VH from anti-IAV HA mAb and human IgG1 CH1-3, and a light chain (LC) with VL and human kappa CL.
-
What functional applications is this antibody validated for?
A: This antibody has been reported for use in Neutralization (Neut) and Function Assays (FuncS). It is tested positive against native IAV HA (Influenza hemagglutinin).
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# PABL-584, RRID: AB_3714458)
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| PFBL-579 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (100F4) | WB, IF, FuncS | Fab |
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| PSBL-579 | Recombinant Human Anti-IAV HA Antibody scFv Fragment (100F4) | WB, IF, FuncS | scFv |
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