Recombinant Human Anti-IAV HA Antibody (AVFluIgG03)
CAT#: PABL-587
Recombinant Human Antibody (AVFluIgG03) is capable of binding to IAV HA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-IAV HA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-IAV HA proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This human monoclonal antibody bound to the globular head of hemagglutinin (HA) with distinct epitope specificities, neutralization potencies and breadth.
Published Data
Figure 1 Inhibition of mAb AVFluIgG03 against HA-mediated virus-receptor binding.
Binding of the A/Vietnam/1203/ 04 H5N1 pseudovirus to MDCK cells was expressed as a percentage of the reading obtained in the absence of antibody, which was set at 100%.
Wu, R., Li, X., Leung, H. C., Cao, Z., Qiu, Z., Zhou, Y., ... & He, Y. (2014). A novel neutralizing antibody against diverse clades of H5N1 influenza virus and its mutants capable of airborne transmission. Antiviral research, 106, 13-23.
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Specifications
- Immunogen
- IAV haemagglutinin
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native IAV HA
- Species Reactivity
- IAV
- Clone
- AVFluIgG03
- Applications
- Neut Assay-depended
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
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User 198*****0514.Jan,24
Excellent for WB
The western blot and ELISA were performed with anti-IAV HA antibody (AVFluIgG03), PABL-587. Hemagglutinin protein of Influenza A H5N1 (A/Vietnam/1194/2004) was used as antigen. The result of western blot is good but the signal of ELISA assay is very weak. These results showed that the antibody may bind to a linear epitope.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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