Mouse Anti-IGHE Recombinant Antibody (clone MAE11) (CAT#: HPAB-0169-LSX)
Recombinant monoclonal antibody to IGHE. Clone MaE11 is a mouse IgG2 that can be potentially used in the treatment of type 1 hypersensitivity, anaphylactic hypersensitivity.
Specific Inquiry
SPR
Figure 1 Increased affinity for soluble human IgE and FcgRIIb of XmAb7195 relative to omalizumab.
Surface plasmon resonance traces of Fv domain of full-length antibody binding to IgE (left panel) and of Fc domain of full-length antibody binding to Fc inhibitory receptor FcγRIIb (right panel). Binding curves for IgE were performed at 3.13, 6.25, 12.5, and 25.0 nM; binding curves for FcγRIIb were performed at 15.62, 62.5, 250, and 1000 nM.
Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcgRIIb with Fc-engineered antibody
Specifications
- Immunogen
- IgE
- Host Species
- Mouse
- Type
- Mouse IgG2
- Specificity
- Human IGHE
- Species Reactivity
- Human
- Clone
- MAE11
- Applications
- ELISA, FC, SPR
- Related Disease
- Type 1 hypersensitivity, anaphylactic hypersensitivity
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Surface Plasmon Resonance.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-092 | Recombinant Anti-human IGHE VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-755 | Anti-IGHE Recombinant Antibody (Ligelizumab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
| TAB-007 | Anti-Human IGHE Recombinant Antibody (Omalizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L061R | anti-IGHE immunotoxin (Fab)-RTA | Cytotoxicity assay, Functional assay |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-256CQ | Human Anti-IGHE Recombinant Antibody (TAB-256CQ) | Agonist | Human IgG2, κ |
| TAB-257CQ | Human Anti-IGHE Recombinant Antibody (TAB-257CQ) | Agonist | Human IgG2, κ |
| TAB-256CQ-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (TAB-256CQ-F(E)) | ELISA, FC, WB | Human Fab |
| TAB-257CQ-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (TAB-257CQ-F(E)) | ELISA, FC, WB | Human Fab |
| TAB-258CQ-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (TAB-258CQ-F(E)) | ELISA, FC, WB | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0168-LSX | Mouse Anti-IGHE Recombinant Antibody (clone MaE10) | ELISA, FC | Mouse IgG1 |
| HPAB-0170-LSX | Human Anti-IGHE Recombinant Antibody (clone 235-5.2) | ELISA, FC | Humanized IgG1 |
| HPAB-0171-LSX | Human Anti-IGHE Recombinant Antibody (HPAB-0171-LSX) | ELISA, RIA | Human IgG |
| HPAB-0172-LSX | Human Anti-IGHE Recombinant Antibody (HPAB-0172-LSX) | ELISA, RIA | Human IgG |
| HPAB-0173-LSX | Human Anti-IGHE Recombinant Antibody (HPAB-0173-LSX) | ELISA, RIA | Human IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0168-LSX-S(P) | Mouse Anti-IGHE Recombinant Antibody (clone MaE10); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0169-LSX-S(P) | Mouse Anti-IGHE Recombinant Antibody (clone MAE11); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0170-LSX-S(P) | Human Anti-IGHE Recombinant Antibody (clone 235-5.2); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-0171-LSX-S(P) | Human Anti-IGHE Recombinant Antibody; scFv Fragment (HPAB-0171-LSX-S(P)) | ELISA, RIA | Human scFv |
| HPAB-0028-YJ-S(P) | Human Anti-IGHE Recombinant Antibody (clone E26); scFv Fragment | ELISA | Humanized scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0168-LSX-F(E) | Mouse Anti-IGHE Recombinant Antibody (clone MaE10); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0169-LSX-F(E) | Mouse Anti-IGHE Recombinant Antibody (clone MAE11); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0170-LSX-F(E) | Human Anti-IGHE Recombinant Antibody (clone 235-5.2); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-0171-LSX-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (HPAB-0171-LSX-F(E)) | ELISA, RIA | Human Fab |
| HPAB-0172-LSX-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (HPAB-0172-LSX-F(E)) | ELISA, RIA | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-007 | Afuco™ Anti-IGHE ADCC Recombinant Antibody (Omalizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-255 | Afuco™ Anti-IGHE ADCC Recombinant Antibody (Quilizumab), ADCC Enhanced | IP, IF, FuncS, FC, Neut | ADCC enhanced antibody |
| AFC-TAB-755 | Afuco™ Anti-IGHE ADCC Recombinant Antibody (Ligelizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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