Human Anti-IL23A Recombinant Antibody (clone CNTO1959) (CAT#: PABL-241)
Recombinant Human Antibody (CNTO1959) is capable of binding to IL-23, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-IL-23 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-IL-23 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
Figure 1 A, Expression of KRT16, IFN-γ, IL-17F, and LCN2 mRNA at baseline and week 12 in lesional and nonlesional biopsy specimens from patients treated with high-dose (100 mg + 300 mg) guselkumab compared with placebo. B, Microarray expression of 1224 transcripts of nonlesional skin at baseline versus lesional skin at baseline and at weeks 1 and 12 after guselkumab treatment.
Sofen, H., Smith, S., Matheson, R. T., Leonardi, C. L., Calderon, C., Brodmerkel, C.,... & Wang, Y. (2014). Guselkumab (an IL-23–specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis. Journal of Allergy and Clinical Immunology, 133(4), 1032-1040.
Figure 2 Serum analyses of circulating IL-17A levels in guselkumab-treated responders (PASI 50 response at week 12) at baseline and at weeks 1 and 12 compared with the placebo-treated group. P values measure the significant difference in posttreatment compared with baseline values.
Sofen, H., Smith, S., Matheson, R. T., Leonardi, C. L., Calderon, C., Brodmerkel, C.,... & Wang, Y. (2014). Guselkumab (an IL-23–specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis. Journal of Allergy and Clinical Immunology, 133(4), 1032-1040.
Figure 3 Evaluation of mean epidermal thickness and T-cell (CD3) and myeloid DC (CD11c) expression from lesional skin biopsy specimens at baseline and after guselkumab or placebo treatment at weeks 1 and 12.
Sofen, H., Smith, S., Matheson, R. T., Leonardi, C. L., Calderon, C., Brodmerkel, C.,... & Wang, Y. (2014). Guselkumab (an IL-23–specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis. Journal of Allergy and Clinical Immunology, 133(4), 1032-1040.
Figure 4 Histologic evaluation of nonlesional and lesional skin at baseline and week 12 after subcutaneous injection of 300 mg of guselkumab. CD3, T cell; CD11c, myeloid DC; H&E, hematoxylin and eosin; KRT16, keratin 16.
Sofen, H., Smith, S., Matheson, R. T., Leonardi, C. L., Calderon, C., Brodmerkel, C.,... & Wang, Y. (2014). Guselkumab (an IL-23–specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis. Journal of Allergy and Clinical Immunology, 133(4), 1032-1040.
Specifications
- Immunogen
- Human interleukin 23, alpha subunit p19
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human IL23A
- Species Reactivity
- Human
- Clone
- CNTO1959
- Applications
- WB, ELISA, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Function Assay. For details, refer to Published Data.
Target
- Alternative Names
- IL23A; interleukin 23; alpha subunit p19; P19; SGRF; IL-23; IL-23A; IL23P19; interleukin-23 subunit alpha; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation; interleukin-six; G-CSF related factor
- Gene ID
- 51561
- UniProt ID
- Q9NPF7
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1953-VHH | Recombinant Anti-human IL23A VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
| TAB-005LC-VHH | Anti-human IL23A Recombinant Antibody (119A3) (TAB-005LC-VHH) | ELISA | Single domain antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-420CL | Anti-Human IL23A Recombinant Antibody (BI 655066) | FuncS | Antibody |
| TAB-622LC | Human Anti-IL23A Recombinant Antibody (TAB-622LC) | ELISA | Human antibody |
| TAB-613LC-F(E) | Anti-human IL23A Fab Fragment (ST883/885) | ELISA | Human antibody |
| TAB-622LC-F(E) | Human Anti-IL23A Recombinant Antibody; Fab Fragment (TAB-622LC-F(E)) | ELISA | Human Fab |
| TAB-008ML | Anti-Human IL23A Recombinant Antibody (Brazikumab) | ELISA, IHC, FC, IP, IF, Inhib | IgG2, λ |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-082 | Human Anti-IL23A Recombinant Antibody (PABW-082) | Neut | Human IgG |
| HPAB-0517-CN | Mouse Anti-IL23A Recombinant Antibody (HPAB-0517-CN) | ELISA, FC | Mouse IgG |
| HPAB-0518-CN | Human Anti-IL23A Recombinant Antibody (HPAB-0518-CN) | ELISA, FC | Humanized IgG |
| HPAB-1231-FY | Human Anti-IL23A Recombinant Antibody (HPAB-1231-FY) | ELISA | Human IgG |
| HPAB-1232-FY | Human Anti-IL23A Recombinant Antibody (HPAB-1232-FY) | ELISA | Human IgG |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-606LC | Anti-human IL23A Recombinant Antibody (E11E7) (TAB-606LC) | ELISA, Neut | |
| TAB-614LC | Anti-human IL23A Recombinant Antibody (8C9) (TAB-614LC) | ELISA, Inhib | |
| TAB-615LC | Anti-human IL23A Recombinant Antibody (2H6) (TAB-615LC) | ELISA, Inhib | |
| TAB-621LC | Mouse Anti-IL23A Recombinant Antibody (TAB-621LC) | ELISA, WB, Neut | Mouse IgG |
| TAB-606LC-S(P) | Anti-human IL23A scFv Fragment (E11E7) | ELISA |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-607LC | Anti-human IL23A Recombinant Antibody (E11E7Chimera) (TAB-607LC) | ELISA, Neut, FuncS | Chimeric antibody (rat/human) |
| TAB-607LC-S(P) | Anti-human IL23A scFv Fragment (E11E7Chimera) | ELISA | Chimeric antibody (rat/human) |
| TAB-607LC-F(E) | Anti-human IL23A Fab Fragment (E11E7Chimera) | ELISA | Chimeric antibody (rat/human) |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-616LC | Anti-human IL23A Recombinant Antibody (A3M0) (TAB-616LC) | ELISA, FC, Inhib, FuncS | Humanized antibody |
| TAB-617LC | Anti-human IL23A Recombinant Antibody (A3M1) (TAB-617LC) | ELISA, FC, Inhib | Humanized antibody |
| TAB-618LC | Anti-human IL23A Recombinant Antibody (A3N1) (TAB-618LC) | ELISA, FC, Inhib | Humanized antibody |
| TAB-605LC-S(P) | Anti-human IL23A scFv Fragment (FM303) | ELISA | Humanized antibody |
| TAB-608LC-S(P) | Anti-human IL23A scFv Fragment (21-4) | ELISA | Humanized antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1335CQ | Mouse Anti-IL23A Recombinant Antibody (clone HNU2319) | FuncS, Neut | Mouse IgG1, κ |
| NEUT-1336CQ | Rabbit Anti-IL23A Recombinant Antibody (VMC198) | WB, Neut | Rabbit IgG2b |
| NEUT-1337CQ | Human Anti-IL23A Recombinant Antibody (clone CBL1018) | Neut | Human IgG1, κ |
| NEUT-1338CQ | Mouse Anti-IL23A Recombinant Antibody (clone M066) | Neut | Mouse IgG1 |
| NEUT-1339CQ | Mouse Anti-Il23a Recombinant Antibody (clone CBL1028) | Neut | Mouse IgG2b, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4335 | Rabbit Anti-IL23A Recombinant Antibody (clone SI424DS) | ELISA | Rabbit IgG |
| MOR-4615 | Rabbit Anti-IL23A Recombinant Antibody (clone TH128DS) | WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0516-CN-S(P) | Human Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0516-CN-S(P)) | ELISA, FC, Neut | Human scFv |
| HPAB-0517-CN-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0517-CN-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0518-CN-S(P) | Human Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0518-CN-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-1751-FY-F(E) | Human Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-1751-FY-F(E)) | ELISA | Humanized Fab |
| HPAB-1753-FY-F(E) | Human Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-1753-FY-F(E)) | ELISA | Humanized Fab |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0516-CN-F(E) | Human Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-0516-CN-F(E)) | ELISA, FC, Neut | Human Fab |
| HPAB-0517-CN-F(E) | Mouse Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-0517-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0518-CN-F(E) | Human Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-0518-CN-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-655-FY-F(E) | Mouse Anti-IL23A Recombinant Antibody (clone 8C92H6); Fab Fragment | ELISA | Mouse Fab |
| HPAB-656-FY-F(E) | Human Anti-IL23A Recombinant Antibody (clone A5M20); Fab Fragment | Inhib | Humanized Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-875 | Afuco™ Anti-IL23A ADCC Recombinant Antibody (Tildrakizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-620LC | Afuco™ Anti-IL23A ADCC Recombinant Antibody (Risankizumab), ADCC Enhanced | ELISA | ADCC enhanced antibody |
| AFC-TAB-008ML | Afuco™ Anti-IL23A ADCC Recombinant Antibody (Brazikumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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