Mouse Anti-IL10RA Recombinant Antibody (clone 7Q35)
CAT#: NEUT-1135CQ
This antibody is a mouse monoclonal antibody that binds specifically to IL10 Receptor alpha, and it can neutralize the bioactivity of IL10 Receptor alpha.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HDLM-2
Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65647/1962_E9_3_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line K-562
Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69086/1993_G10_3_selected.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000110324-IL10RA
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Specifications
- Immunogen
- Recombinant human IL-10 R alpha EC domain
- Host Species
- Mouse
- Type
- Mouse IgG2
- Specificity
- Human IL10RA
- Species Reactivity
- Human
- Clone
- 7Q35
- Applications
- Neut
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein G purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- IL10RA; interleukin 10 receptor; alpha; CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1; interleukin-10 receptor subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R subunit alpha; IL-10 receptor subunit alpha; interleukin-10 receptor subunit 1; interleukin-10 receptor alpha chain
- Gene ID
- 3587
- UniProt ID
- Q13651
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Successful Bioactivity Neutralization
This mouse monoclonal antibody (clone 7Q35) is highly effective at neutralizing the bioactivity of the IL10 Receptor alpha. We used it to inhibit the immunosuppressive signals of IL-10 in our myeloid cell cultures. The results were significant and aligned perfectly with our hypothesis regarding the receptor's signaling pathway.
Specific Binding to IL10RA
Specificity is crucial when studying cytokine receptors, and this antibody binds specifically to the human IL10RA extracellular domain. We confirmed its purity with SDS-PAGE (>95%) before use. It has been a dependable tool for dissecting the JAK1 and TYK2 kinase phosphorylation events downstream of receptor activation.
Q&As
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What is the biological activity of this IL10RA antibody?
A: This Mouse Anti-IL10RA Recombinant Antibody (clone 7Q35) binds specifically to the IL10 Receptor alpha and is capable of neutralizing the bioactivity of the receptor. The IL10 receptor mediates the immunosuppressive signal of interleukin 10, so this antibody is a key tool for studying these signaling pathways.
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What is the immunogen and purity of this clone?
A: The immunogen used was the Recombinant human IL-10 R alpha extracellular domain. The antibody is a Mouse IgG2 purified by Protein G to a purity of>95% (SDS-PAGE). It allows for the study of receptor activation, which leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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