Anti-IL2 Antibody-Cytokine Fusion Protein, IL2-IgG (S4B6)
CAT#: ACFP-SH059
This antibody-cytokine fusion protein was achieved by conjugating/fusing the IL2 to light chain of anti-IL2 mAb S4B6 through flexible oligopeptide spacer (Gly4Ser)3. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the IL2 as well as the biological activity of IL2. This protein chimera mimics the structure of IL2/S4B6 mAb immunocomplexes but eliminates general disadvantages of immunocomplexes like possible excess of either IL2 or anti-IL2 mAb and their dissociation to antibody and IL2 at low concentrations. This immunocytokine was designed for treating tumor.
Gene Expression
Normal Tissue
Figure 1 Colon
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_7_3.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_6_6.jpg
RNA Expression
Figure 4 RNA cell line category: Not detected
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000109471-IL2
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Specifications
- Target
- IL2
- Molecule Class
- L Kappa; IL2-IgG2a
- Species Reactivity
- Mouse
- Expression Host
- CHO
- Clone
- S4B6
- Related Disease
- Tumor
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Mouse
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
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Related Diseases
Autoimmune Thyroid Disease
Maturity Onset Diabetes of the Young
Downloadable Resources
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Datasheet
MSDS
COA
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