Anti-IL2 Antibody-Cytokine Fusion Protein, IL2-IgG (S4B6) (CAT#: ACFP-SH059)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the IL2 to light chain of anti-IL2 mAb S4B6 through flexible oligopeptide spacer (Gly4Ser)3. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the IL2 as well as the biological activity of IL2. This protein chimera mimics the structure of IL2/S4B6 mAb immunocomplexes but eliminates general disadvantages of immunocomplexes like possible excess of either IL2 or anti-IL2 mAb and their dissociation to antibody and IL2 at low concentrations. This immunocytokine was designed for treating tumor.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Target
  • IL2
  • Molecule Class
  • L Kappa; IL2-IgG2a
  • Species Reactivity
  • Mouse
  • Expression Host
  • CHO
  • Clone
  • S4B6
  • Related Disease
  • Tumor
  • Cytokine 1
  • IL2
  • Cytokines 1 Description
  • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
  • Cytokine 1 Species
  • Mouse
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • IL2; Interleukin-2; Lymphokine; T Cell Growth Factor; TCGF; IL-2; Interleukin 2; Aldesleukin

Related Resources

  • Related Diseases

Downloads

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Single-domain Antibody

CAT Product Name Application Type
NABG-093 Recombinant Anti-Mouse Il2 VHH Single Domain Antibody ELISA, IHC, FC, FuncS Llama VHH

Deglycosylated Antibody (Non-glycosylated IgGs)

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0283MZ Chicken Anti-Interleukin-2 Polyclonal IgY WB, Indirect ELISA Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1309CQ Mouse Anti-IL2 Recombinant Antibody (VMC195) FC, Block Mouse IgG1
NEUT-1315CQ Rat Anti-Il2 Recombinant Antibody (clone 1A12), Biotin Block, ELISA, WB Rat IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1801 Rabbit Anti-IL2 Recombinant Antibody (clone DS1801AB) ICC, IHC-P, WB Rabbit IgG
MOR-4612 Rabbit Anti-IL2 Recombinant Antibody (clone TH125DS) WB, IHC-P Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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