Anti-human IL23A Recombinant Antibody (A3M0) (TAB-616LC) (CAT#: TAB-616LC)
It is a humanized monoclonal antibody binding with interleukin 23 subunit alpha (IL23A), which is a key cytokine playing different roles in innate and adaptive immunity. The antibody was purified by affinity chromatography. It specifically binds to human IL-23 and can be potentially used in the research of rheumatoid arthritis.
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Figure 1 The ability of tissue culture supernatant humanised mAbs to bind to human IL-23.
ELISA
Figure 2 The ability of purified humanised mAbs to bind to human IL-23.
All samples were run in duplicate, and averages of each duplicate are shown. In addition, the assays using supernatant material were run twice using different preparations of tissue culture supernatant and a representative result is shown.
Inhib
Figure 3 The ability of tissue culture supernatant humanised mAbs to inhibit binding of human IL-23 to human IL-23R.
Inhib
Figure 4 The ability of purified humanised mAbs to inhibit binding of human IL-23 to human IL-23R.
Inhib
Figure 5 The ability of purified humanised mAbs to inhibit binding of cynomolgus IL-23 to human IL-23R.
FuncS
Figure 6 % inhibition of IL-22 production in this assay.
Figure 7 Anti-IL23 mAbs had no effect on the production of IL-12-driven IFNγ production from NK92 cells.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- A3M0
- Applications
- ELISA, FC, Inhib, FuncS
- Related Disease
- Rheumatoid Arthritis
Applications
- Application Notes
- This antibody has been tested for use in Enzyme-Linked Immunosorbent Assay, Inhibition and Functional Assay.
Target
- Alternative Names
- IL23A; interleukin 23, alpha subunit p19; P19; SGRF; IL-23; IL-23A; IL23P19; interleukin-23 subunit alpha; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation; interleukin-six, G-CSF related factor
- Gene ID
- 51561
- UniProt ID
- Q9NPF7
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1953-VHH | Recombinant Anti-human IL23A VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
| TAB-005LC-VHH | Anti-human IL23A Recombinant Antibody (TAB-005LC-VHH) | ELISA | Single domain antibody |
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For Research Use Only. Not For Clinical Use.
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