Afuco™ Anti-Human IL2RA ADCC Recombinant Antibody (HuMax-TAC), ADCC Enhanced (CAT#: AFC-407CL)
Anti-IL2RA ADCC Enhanced Antibody (HuMax-TAC) is an ADCC enhanced antibody produced by our Afuco™ platform. HuMax-TAC specifically targets the TAC antigen and strongly inhibits IL-2 binding to the IL-2R and antigen-induced T cell proliferation. It is used for the treatment of acute renal transplant rejection and has been in development for the treatment of T cell leukemia, multiple sclerosis, graft-versus-host disease, ulcerative colitis, uveitis and asthma.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg
Figure 2 Tonsil
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg
Figure 3 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
Figure 3 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Autoimmune Diseases
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Target
- Alternative Names
- IL2RA; interleukin 2 receptor, alpha; p55; CD25; IL2R; TCGFR; IDDM10; interleukin-2 receptor subunit alpha; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha
- Gene ID
- 3559
- UniProt ID
- P01589
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "IL2RA"
Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B073(A) | Recombinant Anti-human IL2RA Intrabody [(D-Arg)9] | IF, ELISA, FuncS | scFv-(D-Arg)9 |
| IAB-B073(G) | Recombinant Anti-human IL2RA Intrabody [+36 GFP] | IF, FC, WB, FuncS | scFv-(+36GFP) |
| IAB-B073(T) | Recombinant Anti-human IL2RA Intrabody [Tat] | WB, CO-IP, FuncS | scFv-Tat |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-004 | Anti-Human CD25 Recombinant Antibody (Basiliximab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
| PABX-030 | Recombinant Human Anti-CD25 Antibody (SDZCHII621) | Neut, FuncS | IgG |
| PABX-030-F (E) | Recombinant Mouse Anti-CD25 Antibody Fab Fragment (SDZCHII621) | Neut, FuncS | Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-155 | Anti-Human CD25 Recombinant Antibody (Inolimomab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 - kappa |
| TAB-641LC | Anti-human IL2RA Recombinant Antibody (Inolimomab) (TAB-641LC) | ELISA | |
| TAB-641LC-S(P) | Anti-human IL2RA scFv Fragment (Inolimomab) | ELISA | |
| TAB-641LC-F(E) | Anti-human IL2RA Fab Fragment (Inolimomab) | ELISA | |
| PABX-029-S (P) | Recombinant Human Anti-CD25 Antibody scFv Fragment (Daclizumab) | WB, ELISA, FuncS | scFv |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L027D | anti-IL2RA immunotoxin RFT5 (scFv)-DT | Cytotoxicity assay, Functional assay | |
| AGTO-L027R | anti-IL2RA immunotoxin RFT5 (scFv)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L028E | anti-IL2RA immunotoxin RFT5 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L028D | anti-IL2RA immunotoxin RFT5 (IgG)-DT | Cytotoxicity assay, Functional assay | |
| AGTO-L028R | anti-IL2RA immunotoxin RFT5 (IgG)-RTA | Cytotoxicity assay, Functional assay |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-242 | Human Anti-IL2RA Recombinant Antibody (clone 1H4) | WB, IHC, FuncS | Human IgG |
| PABL-613 | Human Anti-IL2RA Recombinant Antibody (clone RTF5) | WB, FuncS | Chimeric (mouse/human) IgG |
| FAMAB-0197CQ | Mouse Anti-IL2RA Recombinant Antibody (clone 2C8) | ELISA, WB, FC | Mouse IgG1, κ |
| FAMAB-0198CQ | Human Anti-IL2RA Recombinant Antibody (clone 4C1) | ELISA, WB, FC | Chimeric (mouse/human) IgG1, κ |
| FAMAB-0199CQ | Mouse Anti-IL2RA Recombinant Antibody (clone 4F8) | ELISA, WB, FC | Mouse IgG2a, κ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-242 | Human Anti-IL2RA Recombinant Antibody (clone 1H4); scFv Fragment | WB, IHC, FuncS | Human scFv |
| HPAB-0559-WJ-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (HPAB-0559-WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0560-WJ-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (HPAB-0560-WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0561-WJ-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (HPAB-0561-WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-2113-FY-S(P) | Mouse Anti-IL2RA Recombinant Antibody (clone MAK179); scFv Fragment | Inhib | Mouse scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-642LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-642LC-S(P)) | ELISA, FC | Human scFv |
| TAB-643LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-643LC-S(P)) | ELISA, FC | Human scFv |
| TAB-644LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-644LC-S(P)) | ELISA, FC | Human scFv |
| TAB-642LC-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (TAB-642LC-F(E)) | ELISA, FC | Human Fab |
| PABX-029-F (E) | Recombinant Human Anti-CD25 Antibody Fab Fragment (Daclizumab) | WB, ELISA, FuncS | Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-646LC-F(E) | Anti-human IL2RA Fab Fragment (48M54S) | ELISA, FC | Humanized antibody |
| TAB-647LC-F(E) | Anti-human IL2RA Fab Fragment (48M51L) | ELISA, FC | Humanized antibody |
| TAB-648LC-F(E) | Anti-human IL2RA Fab Fragment (48V54S) | ELISA, FC | Humanized antibody |
| TAB-649LC-F(E) | Anti-human IL2RA Fab Fragment (Dmab) | FC | Humanized antibody |
| TAB-650LC-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (TAB-650LC-F(E)) | ELISA | Humanized Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1344CQ | Mouse Anti-IL2RA Recombinant Antibody (clone B-B10) | FC, Neut, WB, IF | Mouse IgG1, κ |
| NEUT-1345CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL017) | Neut, WB, IHC | Mouse IgG1 |
| NEUT-1346CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL242) | ELISA, FC, Neut | Mouse IgG1, κ |
| NEUT-1348CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL726) | WB, IHC, ICC, Neut | Mouse IgG1 |
| NEUT-1349CQ | Mouse Anti-IL2RA Recombinant Antibody (clone 1X27) | IHC, Neut, WB | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1350CQ | Mouse Anti-IL2RA Recombinant Antibody (clone 2R12) | Block, FC, ICC, IF, IHC, IP, WB | Mouse IgG1 |
| NEUT-1356CQ | Rat Anti-Il2ra Recombinant Antibody (VMC199) | FC, IP, IHC, Block, Depletion | Rat IgG1, λ |
| NEUT-1357CQ | Rat Anti-Il2ra Recombinant Antibody (clone 3C7) | FC, IP, Inhib | Rat IgG2b, κ |
| NEUT-1358CQ | Rat Anti-Il2ra Recombinant Antibody (clone mAb0817) | Block, Depletion | Rat IgG1 |
| NEUT-1359CQ | Rat Anti-Il2ra Recombinant Antibody (clone mAb0845) | Block, FC, IHC-Fr, IP | Rat IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1808 | Rabbit Anti-IL2RA Recombinant Antibody (clone DS1808AB) | IHC, ICC, IP | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0197CQ-F(E) | Mouse Anti-IL2RA Recombinant Antibody (clone 2C8); Fab Fragment | ELISA, WB, FC | Mouse Fab |
| FAMAB-0198CQ-F(E) | Human Anti-IL2RA Recombinant Antibody (clone 4C1); Fab Fragment | ELISA, WB, FC | Chimeric (mouse/human) Fab |
| FAMAB-0199CQ-F(E) | Mouse Anti-IL2RA Recombinant Antibody (clone 4F8); Fab Fragment | ELISA, WB, FC | Mouse Fab |
| FAMAB-0200CQ-F(E) | Human Anti-IL2RA Recombinant Antibody (clone huD1); Fab Fragment | ELISA, FC, Block | Humanized Fab |
| FAMAB-0201CQ-F(E) | Mouse Anti-IL2RA Recombinant Antibody (clone D1); Fab Fragment | ELISA, FC, Block | Mouse Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-004 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Basiliximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-023 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Daclizumab), ADCC Enhanced | ELISA, Neut, IF, IP, FC, FuncS | ADCC enhanced antibody |
| AFC-TAB-155 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Inolimomab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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