Human Anti-IL34 Recombinant Antibody (clone Ab1.1) (CAT#: PABL-614)
Recombinant Human Antibody (Ab1.1) is capable of binding to IL34, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-IL34 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-IL34 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody has IL-34 high binding affinity and blocking activity.
Specific Inquiry
Figure 1 Inhibition of IL-34 biological activity by Ab1.1 in the monocyte viability assay.
In human monocyte viability assay, the biological activity of IL-34 is effectively blocked by this antibody. Error bars indicate standard deviation of triplicate samples.
Ma, X., Lin, W. Y., Chen, Y., Stawicki, S., Mukhyala, K., Wu, Y., ... & Starovasnik, M. A. (2012). Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R. Structure, 20(4), 676-687.
Specifications
- Immunogen
- Human interleukin 34
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human IL34
- Species Reactivity
- Human
- Clone
- Ab1.1
- Applications
- Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- IL34; interleukin 34; IL-34; C16orf77; interleukin-34
- Gene ID
- 146433
- UniProt ID
- Q6ZMJ4
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1506-sdAb | Recombinant Anti-Human IL34 VHH Single Domain Antibody | FA, FC, ICC, ELISA | Llama VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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