Afuco™ Anti-IL4R Recombinant Antibody (AFC-416CL), ADCC Enhanced (CAT#: AFC-416CL)
Anti-IL4R ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. It is a fully human monoclonal antibody to IL-4Ralpha that blocks both IL-4 and IL-13 pathways.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to nucleoplasm, plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70380/1812_F10_5_cr59ef13a97c5ff_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to nucleoplasm, plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70380/1812_F10_5_cr59ef13a97c5ff_selected.jpg
Figure 2 Tonsil
(High expression in tonsil)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/ihc_selected.jpg
(High expression in tonsil)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/ihc_selected.jpg
Figure 3 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows distinct cytoplasmic positivity in subsets of cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4451/ihc_selected.jpg
(Immunohistochemical staining of human tonsil shows distinct cytoplasmic positivity in subsets of cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4451/ihc_selected.jpg
Figure 4 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/123264_A_9_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/123264_A_9_3.jpg
Figure 5 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/123264_A_8_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/123264_A_8_5.jpg
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HBEC3-KT, HDLM-2, U-698)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077238-IL4R
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077238-IL4R
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG1
- Species Reactivity
- Human
- Applications
- ELISA, WB
- Related Disease
- Asthma
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- IL4R; interleukin 4 receptor; CD124; IL4RA; IL-4RA; interleukin-4 receptor subunit alpha; IL4R nirs variant 1; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain
- Gene ID
- 3566
- UniProt ID
- P24394
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1757z | Mouse Anti-IL4R Recombinant Antibody (clone 28H12) | WB, ELISA, FC, IHC, FuncS | Mouse IgG1 |
| HPAB-0344LY | Human Anti-IL4R Recombinant Antibody (HPAB-0344LY) | Block, ELISA | Human IgG1 |
| HPAB-0345LY | Human Anti-IL4R Recombinant Antibody (HPAB-0345LY) | Block, ELISA | Human IgG1 |
| HPAB-0346LY | Human Anti-IL4R Recombinant Antibody (HPAB-0346LY) | Block, ELISA | Human IgG1 |
| HPAB-0347LY | Human Anti-IL4R Recombinant Antibody (HPAB-0347LY) | Block, ELISA | Human IgG1 |
Customer Reviews and Q&As
Customer Review
Cha***s
Outstanding ELISA Results with Afuco® Anti-IL4R Recombinant Antibody (AFC-416CL), ADCC Enhanced (AFC-416CL).
Outstanding ELISA Results with Afuco® Anti-IL4R Recombinant Antibody (AFC-416CL), ADCC Enhanced (AFC-416CL).
We are extremely pleased with the ELISA results for your Afuco® Anti-IL4R Recombinant Antibody (AFC-416CL), ADCC Enhanced (AFC-416CL). The remarkably low EC₅₀ of 4.3 ng/mL highlights its exceptionally high affinity for human IL4R, significantly exceeding our expectations. This high-quality antibody will be invaluable for our research on IL4R binding and signaling. Thank you for providing such an efficient and excellent product; we are very satisfied.
21-Apr-24
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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