Human Anti-ITGAL Recombinant Antibody (clone MHM24) (CAT#: NS-018CN)

Recombinant monoclonal antibody to CD11a. MHM24 is an IgG1 antibody that can be used in the treatment of LFA-1-mediated disorder, like asthma, rheumatoid arthritis, graft versus host or host versus graft rejection in transplantation, multiple sclerosis, psoriasis, systemic lupus erythmatosus, dermatitis, Crohn's disease, and ulcerative colitis.


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Inhib

Figure 1 Inhibition of human Jurkat T-cells to normal human keratinocytes by murine MHM24 (filled circles), chimeric MHM24 (open triangles), humanized MHM24 (HuIG1) (filled squares), and a human IgG1 isotype control (+).

Figure 1 Inhibition of human Jurkat T-cells to normal human keratinocytes by murine MHM24 (filled circles), chimeric MHM24 (open triangles), humanized MHM24 (HuIG1) (filled squares), and a human IgG1 isotype control (+).

Percent binding measured by fluorescence of labeled Jurkat cells.

Inhib

Figure 2 Human mixed lymphocyte response assy (MLR) is blocked by murine MHM24 (filled circles), humanized MHM24 (HuIgG1) (filled squares), and a humanized isotype IgG1 control (filled diamond).

Figure 2 Human mixed lymphocyte response assy (MLR) is blocked by murine MHM24 (filled circles), humanized MHM24 (HuIgG1) (filled squares), and a humanized isotype IgG1 control (filled diamond).

Percent stimulation index (%SI) is the ratio of the response at a given MAb concentration to the maximal response with no MAb present. Data is representative of multiple assays using at least two different stimulator/responder pairs.

FuncS

Figure 3 Inhibition of binding of rhesus lymphocytes to normal human keratinocytes (FIG. A), rhesus lymphocytes to recombinant human ICAM-1 coated on plates (FIG. B), and rhesus/human CD11a chimera-transfected 293 cells to normal human keratinocytes (FIG. C).

Figure 3 Inhibition of binding of rhesus lymphocytes to normal human keratinocytes (FIG. A), rhesus lymphocytes to recombinant human ICAM-1 coated on plates (FIG. B), and rhesus/human CD11a chimera-transfected 293 cells to normal human keratinocytes (FIG. C).

Inhibition by rhesus-binding MHM24 (RhIgG1) (filled squares), anti-CD18 MHM23 (filled circles), a human IgG1 isotype control (+) (FIGS. A and C), and a murine IgG1 isotype control (+) (FIG. B). Percent binding measured by fluorescence of labeled lymphocytes (FIGS. A and B) or labeled 293 cells (FIG. C).


Specifications

  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • Human IgG1
  • Specificity
  • Human ITGAL
  • Species Reactivity
  • Human
  • Clone
  • MHM24
  • Applications
  • FC, ELISA, Inhib, FuncS
  • Related Disease
  • LFA-1-mediated disorder

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Applications

  • Application Notes
  • This antibody has been tested for use in Inhibition, Functional Assay.

Target

  • Alternative Names
  • CD11A; LFA-1; LFA1A

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone MHM24"

See other products for "ITGAL"

Humanized Antibody

CAT Product Name Application Type
TAB-024 Anti-Human CD11A Recombinant Antibody (Efalizumab) Neut, ELISA, IF, IP, FuncS, FC, WB IgG1 - kappa

Chimeric Antibody

CAT Product Name Application Type
TAB-755LC Anti-human ITGAL Recombinant Antibody (Chimeric S6F1) (TAB-755LC) ELISA Chimeric antibody (mouse/human)
TAB-755LC-S(P) Anti-human ITGAL scFv Fragment (Chimeric S6F1) ELISA Chimeric antibody (mouse/human)
TAB-755LC-F(E) Anti-human ITGAL Fab Fragment (Chimeric S6F1) ELISA Chimeric antibody (mouse/human)

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1559CQ Recombinant Mouse Anti-ITGAL Antibody (38) FC, ICC/IF, IHC-Fr, IP, Neut IgG2a
NEUT-1563CQ Recombinant Mouse Anti-ITGAL Antibody (CBL227) FC, IHC, IP, Neut IgG2a
NEUT-1565CQ Recombinant Rat Anti-Itgal Antibody (121/7) FC, IP, Neut, WB IgG2a
NEUT-1568CQ Recombinant Rat Anti-Itgal Antibody (I21/7) Neut, FC, IHC, IHC-Fr, IP, ICC IgG2a, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1878 Hi-Affi™ Recombinant Rabbit Anti-ITGAL Monoclonal Antibody (DS1878AB) BL, FC, ICC/IF, IHC-P, IP, WB IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-108 Afuco™ Anti-ITGAL ADCC Recombinant Antibody (Odulimomab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody
AFC-TAB-024 Afuco™ Anti-ITGAL ADCC Recombinant Antibody (Efalizumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody

Single-domain Antibody

CAT Product Name Application Type
MOB-0066SW Recombinant Llama Anti-ITGAL Single Domain Antibody (138-B10) ELISA, WB Llama VHH

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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