Recombinant monoclonal antibody to CD11a. MHM24 is an IgG1 antibody that can be used in the treatment of LFA-1-mediated disorder, like asthma, rheumatoid arthritis, graft versus host or host versus graft rejection in transplantation, multiple sclerosis, psoriasis, systemic lupus erythmatosus, dermatitis, Crohn's disease, and ulcerative colitis.
Figure 1 Inhibition of human Jurkat T-cells to normal human keratinocytes by murine MHM24 (filled circles), chimeric MHM24 (open triangles), humanized MHM24 (HuIG1) (filled squares), and a human IgG1 isotype control (+).
Percent binding measured by fluorescence of labeled Jurkat cells.
Figure 2 Human mixed lymphocyte response assy (MLR) is blocked by murine MHM24 (filled circles), humanized MHM24 (HuIgG1) (filled squares), and a humanized isotype IgG1 control (filled diamond).
Percent stimulation index (%SI) is the ratio of the response at a given MAb concentration to the maximal response with no MAb present. Data is representative of multiple assays using at least two different stimulator/responder pairs.
Figure 3 Inhibition of binding of rhesus lymphocytes to normal human keratinocytes (FIG. A), rhesus lymphocytes to recombinant human ICAM-1 coated on plates (FIG. B), and rhesus/human CD11a chimera-transfected 293 cells to normal human keratinocytes (FIG. C).
Inhibition by rhesus-binding MHM24 (RhIgG1) (filled squares), anti-CD18 MHM23 (filled circles), a human IgG1 isotype control (+) (FIGS. A and C), and a murine IgG1 isotype control (+) (FIG. B). Percent binding measured by fluorescence of labeled lymphocytes (FIGS. A and B) or labeled 293 cells (FIG. C).
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1129z | Mouse Anti-ITGAL Recombinant Antibody (clone 44C9) | IP, FC, FuncS | Mouse IgG1 |
MOB-2281MZ | Recombinant Mouse Anti-Human ITGAL Antibody (clone C-C26) | FC | Mouse antibody |
MOB-008CQ | Rat Anti-Mouse ITGAL Antibody (M17/4), Alexa Fluor® 647 | FC, IHC, IP | Rat IgG2a, κ |
VS3-WK1238 | Mouse Anti-ITGAL Recombinant Antibody (VS3-WK1238) | WB | Mouse IgG1 |
VS3-FY771 | Recombinant Rabbit Anti-Itgal Antibody (clone R08-3I4) | WB, IHC-P | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-024 | Anti-Human CD11A Recombinant Antibody (Efalizumab) | Neut, ELISA, IF, IP, FuncS, FC, WB | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-108 | Anti-Human CD11a Recombinant Antibody (Odulimomab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 |
TAB-459CL | Mouse Anti-ITGAL Recombinant Antibody (TAB-459CL) | ELISA | Mouse IgG |
TAB-1579CL | Rat Anti-ITGAL Recombinant Antibody (TAB-1579CL) | Block | Rat IgG2a, κ |
TAB-1579CL-S(P) | Rat Anti-ITGAL Recombinant Antibody; scFv Fragment (TAB-1579CL-S(P)) | Block | Rat scFv |
TAB-1579CL-F(E) | Rat Anti-ITGAL Recombinant Antibody; Fab Fragment (TAB-1579CL-F(E)) | Block | Rat Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBW-159 | Human Anti-ITGAL Recombinant Antibody (clone AL-57); Fab Fragment | WB | Human Fab |
NS-018CN-F(E) | Human Anti-ITGAL Recombinant Antibody (clone MHM24); Fab Fragment | FC, ELISA | Human Fab |
HPAB-0487-WJ-F(E) | Mouse Anti-ITGAL Recombinant Antibody (clone S6F1); Fab Fragment | ELISA | Mouse Fab |
HPAB-S0088-YC-F(E) | Human Anti-ITGAL Recombinant Antibody (clone chMHM24); Fab Fragment | Inhib | Chimeric (mouse/human) Fab |
HPAB-S0089-YC-F(E) | Human Anti-ITGAL Recombinant Antibody (clone huMHM24); Fab Fragment | Inhib | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBW-159 | Human Anti-ITGAL Recombinant Antibody (clone AL-57); scFv Fragment | WB | Human scFv |
NS-018CN-S(P) | Human Anti-ITGAL Recombinant Antibody (clone MHM24); scFv Fragment | FC, ELISA | Human scFv |
HPAB-0487-WJ-S(P) | Mouse Anti-ITGAL Recombinant Antibody (clone S6F1); scFv Fragment | ELISA | Mouse scFv |
HPAB-S0088-YC-S(P) | Human Anti-ITGAL Recombinant Antibody (clone chMHM24); scFv Fragment | Inhib | Mouse scFv |
HPAB-S0089-YC-S(P) | Human Anti-ITGAL Recombinant Antibody (clone huMHM24); scFv Fragment | Inhib | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-755LC | Anti-human ITGAL Recombinant Antibody (Chimeric S6F1) (TAB-755LC) | ELISA | Chimeric antibody (mouse/human) |
TAB-755LC-S(P) | Anti-human ITGAL scFv Fragment (Chimeric S6F1) | ELISA | Chimeric antibody (mouse/human) |
TAB-755LC-F(E) | Anti-human ITGAL Fab Fragment (Chimeric S6F1) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1559CQ | Recombinant Mouse Anti-ITGAL Antibody (38) | FC, ICC/IF, IHC-Fr, IP, Neut | IgG2a |
NEUT-1563CQ | Recombinant Mouse Anti-ITGAL Antibody (CBL227) | FC, IHC, IP, Neut | IgG2a |
NEUT-1565CQ | Recombinant Rat Anti-Itgal Antibody (121/7) | FC, IP, Neut, WB | IgG2a |
NEUT-1568CQ | Recombinant Rat Anti-Itgal Antibody (I21/7) | Neut, FC, IHC, IHC-Fr, IP, ICC | IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1560CQ | Recombinant Mouse Anti-ITGAL Antibody (HI111) | FC, BL | IgG1, κ |
NEUT-1561CQ | Recombinant Mouse Anti-ITGAL Antibody (MEM-83) | BL, FC, FuncS, IP | IgG1 |
NEUT-1562CQ | Recombinant Mouse Anti-ITGAL Antibody (TS-1/22.1.1.13) | BL, FC | IgG1 |
NEUT-1564CQ | Recombinant Mouse Anti-ITGAL Antibody (R7-1) | BL, FC | IgG1 |
NEUT-1566CQ | Recombinant Rat Anti-Itgal Antibody (M17/4) | IP, IHC-Fr, FuncS, FC, BL | IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1878 | Hi-Affi™ Recombinant Rabbit Anti-ITGAL Monoclonal Antibody (DS1878AB) | BL, FC, ICC/IF, IHC-P, IP, WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-108 | Afuco™ Anti-ITGAL ADCC Recombinant Antibody (Odulimomab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-024 | Afuco™ Anti-ITGAL ADCC Recombinant Antibody (Efalizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0066SW | Recombinant Llama Anti-ITGAL Single Domain Antibody (138-B10) | ELISA, WB | Llama VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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