Mouse Anti-ITGB3 Recombinant Antibody (clone OPG2) (CAT#: PABW-083)
Recombinant Mouse Antibody (OPG2) is capable of binding to Integrin β3.
Specific Inquiry
Figure 1 Loss of mAb OPG2 binding following substitution of β3 Asp217 or Glu220.
The binding of the activation-independent ligand mimetic mAb OPG2 to Chinese hamster ovary cells transiently transfected with wild type aIIb and the indicated β3 mutant was examined by flow cytometry. In each panel, the binding of OPG2 to the indicated mutant (open histogram) is superimposed on the binding of OPG2 to cells transfected with wild type aIIbβ3. Results are expressed as histograms of cell number versus log fluorescence intensity.
Tozer, E. C., Liddington, R. C., Sutcliffe, M. J., Smeeton, A. H., & Loftus, J. C. (1996). Ligand binding to integrin αIIbβ3 is dependent on a MIDAS-like domain in the β3 subunit. Journal of Biological Chemistry, 271(36), 21978-21984.
Specifications
- Immunogen
- Human integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- Mouse IgG
- Specificity
- Human ITGB3
- Species Reactivity
- Human
- Clone
- OPG2
- Applications
- Block
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16; integrin beta-3; platelet membrane glycoprotein IIIa;
- Gene ID
- 3690
- UniProt ID
- P05106
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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