Anti-human Integrin αIIbβ3 Recombinant Antibody (Chimeric C4G1) (TAB-746LC) (CAT#: TAB-746LC)
Recombinant monoclonal antibody Chimeric C4G1 is a chimeric (mouse/human) monoclonal antibody that specifically binds to human integrin αIIbβ3 and can be potentially used in the treatment of cardiovascular diseases and other thromboembolitic diseases.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
FC
Figure 1 Fluorocytometry of HEL 92.1.7 cells stained with (---) no antibody, (...) chimeric C4G1 antibody, (―) humanized C4G1 antibody. Cells were suspended in FACS buffer (PBS + 2% FCS + 0.1% sodium azide) at approximately 5×106/ml.
ELISA
Figure 2 Competitive binding of humanized and mouse C4G1 antibodies and fragments to platelets.
About 3×107 platelets were incubated with 4.5 ng of radio-iodinated mouse C4G1 tracer antibody (3.5 µCi/µg) and varying amounts of either unlabeled mouse C4G1 antibody or fragments (closed symbols) or humanized C4G1 antibody or fragments (open symbols).
Inhib
Figure 3 Inhibition of platelet aggregation by C4G1 antibody.
The Y-axis shows percent light transmission; the X-axis shows time in minutes. The dark upper curve in each panel shows the increase in light transmission caused by platelet aggregation when no antibody is added; the lighter lower curves show that addition of antibodies strongly inhibits platelet aggregation, as measured by change in light transmission.
Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Chimeric antibody (mouse/human)
- Specificity
- Human
- Clone
- Chimeric C4G1
- Applications
- ELISA, FC, Inhib
- Related Disease
- Cardiovascular diseases and other thromboembolitic diseases
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Flow Cytometry, Inhibition.
Target
- Alternative Names
- Integrin αIIbβ3; Integrin Alpha IIb Beta 3; GPIIb/IIIa; glycoprotein IIb/IIIa; ITGA2B; ITGB3
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
Chimeric Antibody Products
Humanized Antibody Products
Human Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-247 | Mouse Anti-integrin αIIbβ3 Recombinant Antibody (clone 10E5) | WB, ELISA, IF, FuncS | Mouse IgG |
| FAMAB-0113JF | Human Anti-Integrin αIIbβ3 Recombinant Antibody (clone 2F2) | WB, ELISA | Human IgG |
| FAMAB-0114JF | Human Anti-Integrin αIIbβ3 Recombinant Antibody (clone B12) | WB, ELISA, IHC | Human IgG |
| VS2-QX3 | Mouse Anti-Integrin αIIbβ3 Recombinant Antibody (clone PAB-1) | IF | Mouse IgG1, κ |
| VS2-QX4 | Mouse Anti-Integrin αIIbβ3 Recombinant Antibody (clone PAB-6) | IF | Mouse IgG1, κ |
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For Research Use Only. Not For Clinical Use.
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