Anti-human Integrin αIIbβ3 Recombinant Antibody (Chimeric C4G1) (TAB-746LC) (CAT#: TAB-746LC)
Recombinant monoclonal antibody Chimeric C4G1 is a chimeric (mouse/human) monoclonal antibody that specifically binds to human integrin αIIbβ3 and can be potentially used in the treatment of cardiovascular diseases and other thromboembolitic diseases.
Specific Inquiry
FC
Figure 1 Fluorocytometry of HEL 92.1.7 cells stained with (---) no antibody, (...) chimeric C4G1 antibody, (―) humanized C4G1 antibody. Cells were suspended in FACS buffer (PBS + 2% FCS + 0.1% sodium azide) at approximately 5×106/ml.
ELISA
Figure 2 Competitive binding of humanized and mouse C4G1 antibodies and fragments to platelets.
About 3×107 platelets were incubated with 4.5 ng of radio-iodinated mouse C4G1 tracer antibody (3.5 µCi/µg) and varying amounts of either unlabeled mouse C4G1 antibody or fragments (closed symbols) or humanized C4G1 antibody or fragments (open symbols).
Inhib
Figure 3 Inhibition of platelet aggregation by C4G1 antibody.
The Y-axis shows percent light transmission; the X-axis shows time in minutes. The dark upper curve in each panel shows the increase in light transmission caused by platelet aggregation when no antibody is added; the lighter lower curves show that addition of antibodies strongly inhibits platelet aggregation, as measured by change in light transmission.
Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Chimeric antibody (mouse/human)
- Specificity
- Human
- Clone
- Chimeric C4G1
- Applications
- ELISA, FC, Inhib
- Related Disease
- Cardiovascular diseases and other thromboembolitic diseases
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Flow Cytometry, Inhibition.
Target
- Alternative Names
- Integrin αIIbβ3; Integrin Alpha IIb Beta 3; GPIIb/IIIa; glycoprotein IIb/IIIa; ITGA2B; ITGB3
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
Humanized Antibody Products
Human Antibody Products
Chimeric Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-247 | Mouse Anti-integrin αIIbβ3 Recombinant Antibody (clone 10E5) | WB, ELISA, IF, FuncS | Mouse IgG |
| FAMAB-0113JF | Human Anti-Integrin αIIbβ3 Recombinant Antibody (clone 2F2) | WB, ELISA | Human IgG |
| FAMAB-0114JF | Human Anti-Integrin αIIbβ3 Recombinant Antibody (clone B12) | WB, ELISA, IHC | Human IgG |
| VS2-QX3 | Mouse Anti-Integrin αIIbβ3 Recombinant Antibody (clone PAB-1) | IF | Mouse IgG1, κ |
| VS2-QX4 | Mouse Anti-Integrin αIIbβ3 Recombinant Antibody (clone PAB-6) | IF | Mouse IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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