Recombinant monoclonal antibody 22B5 is a human monoclonal antibody that specifically binds to human integrin α5β1 and can be potentially used in the treatment of metastatic melanoma.
Figure 1 Dose-dependent binding of 1D9, 1D9/DLE, 24C7/DLE, 2D2/DLE, 22B5, and 22B5/DLE to HUVEC by FACS.
Figure 2 LDH-based detection assays that indicate substantial ADCC enhancement from 22B5/DLE over wt 22B5 IgG 1 across a broad range of antigen expression levels.
Figure 3 A LDH-based detection assay measuring ADCC of U87MG cells in the presence of human PBMCs by 22B5/DLE and 22B5 wt IgG1.
Figure 4 The results of a HUVEC cellular adhesion blockade assay.
The results indicate the level of inhibition of HUVEC adhesion to fibronectin for 22B5 and various subclass variants as well as the negative control (BHA2 IgG1). The calculated IC50 values are also shown.
Figure 5 Dose-dependent binding of 22B5/DLE to HUVEC by FACS.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-719LC | Anti-human Integrin α5β1 Recombinant Antibody (3C2.2A8) (TAB-719LC) | ELISA, FC | Human antibody |
TAB-720LC | Anti-human Integrin α5β1 Recombinant Antibody (3C5) (TAB-720LC) | ELISA, FC, Inhib | Human antibody |
TAB-721LC | Anti-human Integrin α5β1 Recombinant Antibody (5B11) (TAB-721LC) | ELISA, FC, Inhib | Human antibody |
TAB-722LC | Anti-human Integrin α5β1 Recombinant Antibody (MOR04055) (TAB-722LC) | ELISA, FC, Block, Apop, FuncS | Human antibody |
TAB-723LC | Anti-human Integrin α5β1 Recombinant Antibody (MOR04624) (TAB-723LC) | ELISA, FC, Block, Apop | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-066 | Recombinant Mouse Anti-GPIIb Antibody (314.1) | Neut, FuncS | IgG |
PABX-066-F (E) | Recombinant Mouse Anti-GPIIb Antibody Fab Fragment (314.1) | Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0391-CN | Hamster Anti-Integrin α5β1 Recombinant Antibody (HPAB-0391-CN) | ELISA | Hamster IgG |
HPAB-0392-CN | Human Anti-Integrin α5β1 Recombinant Antibody (HPAB-0392-CN) | ELISA | Chimeric (hamster/human) IgG1, κ |
HPAB-0393-CN | Human Anti-Integrin α5β1 Recombinant Antibody (HPAB-0393-CN) | ELISA | Humanized IgG3, λ |
HPAB-0394-CN | Human Anti-Integrin α5β1 Recombinant Antibody (HPAB-0394-CN) | ELISA | Humanized IgG3, λ |
HPAB-0786-CN | Human Anti-Integrin α5β1 Recombinant Antibody (clone 2H12) | ELISA, FC | Human IgG4, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0392-CN-S(P) | Human Anti-Integrin α5β1 Recombinant Antibody; scFv Fragment (HPAB-0392-CN-S(P)) | ELISA | Human scFv |
HPAB-0393-CN-S(P) | Human Anti-Integrin α5β1 Recombinant Antibody; scFv Fragment (HPAB-0393-CN-S(P)) | ELISA | Human scFv |
HPAB-0786-CN-S(P) | Human Anti-Integrin α5β1 Recombinant Antibody (clone 2H12); scFv Fragment | ELISA, FC | Human scFv |
HPAB-0787-CN-S(P) | Human Anti-Integrin α5β1 Recombinant Antibody (clone 1F2.2B7); scFv Fragment | ELISA, FC | Human scFv |
HPAB-0788-CN-S(P) | Human Anti-Integrin α5β1 Recombinant Antibody (clone 2H12IgG1TM); scFv Fragment | ELISA, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0391-CN-F(E) | Hamster Anti-Integrin α5β1 Recombinant Antibody; Fab Fragment (HPAB-0391-CN-F(E)) | ELISA | Hamster Fab |
HPAB-0392-CN-F(E) | Human Anti-Integrin α5β1 Recombinant Antibody; Fab Fragment (HPAB-0392-CN-F(E)) | ELISA | Human Fab |
HPAB-0393-CN-F(E) | Human Anti-Integrin α5β1 Recombinant Antibody; Fab Fragment (HPAB-0393-CN-F(E)) | ELISA | Human Fab |
HPAB-0394-CN-F(E) | Human Anti-Integrin α5β1 Recombinant Antibody; Fab Fragment (HPAB-0394-CN-F(E)) | ELISA | Human Fab |
HPAB-0786-CN-F(E) | Human Anti-Integrin α5β1 Recombinant Antibody (clone 2H12); Fab Fragment | ELISA, FC | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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