Anti-human Integrin α5β1 Recombinant Antibody (22B5) (TAB-724LC) (CAT#: TAB-724LC)

Recombinant monoclonal antibody 22B5 is a human monoclonal antibody that specifically binds to human integrin α5β1 and can be potentially used in the treatment of metastatic melanoma.


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FC

Figure 1 Dose-dependent binding of 1D9, 1D9/DLE, 24C7/DLE, 2D2/DLE, 22B5, and 22B5/DLE to HUVEC by FACS.

Figure 1 Dose-dependent binding of 1D9, 1D9/DLE, 24C7/DLE, 2D2/DLE, 22B5, and 22B5/DLE to HUVEC by FACS.

ADCC

Figure 2 LDH-based detection assays that indicate substantial ADCC enhancement from 22B5/DLE over wt 22B5 IgG 1 across a broad range of antigen expression levels.

Figure 2 LDH-based detection assays that indicate substantial ADCC enhancement from 22B5/DLE over wt 22B5 IgG 1 across a broad range of antigen expression levels.

ADCC

Figure 3 A LDH-based detection assay measuring ADCC of U87MG cells in the presence of human PBMCs by 22B5/DLE and 22B5 wt IgG1.

Figure 3 A LDH-based detection assay measuring ADCC of U87MG cells in the presence of human PBMCs by 22B5/DLE and 22B5 wt IgG1.

Block

Figure 4 The results of a HUVEC cellular adhesion blockade assay.

Figure 4 The results of a HUVEC cellular adhesion blockade assay.

The results indicate the level of inhibition of HUVEC adhesion to fibronectin for 22B5 and various subclass variants as well as the negative control (BHA2 IgG1). The calculated IC50 values are also shown.

FC

Figure 5 Dose-dependent binding of 22B5/DLE to HUVEC by FACS.

Figure 5 Dose-dependent binding of 22B5/DLE to HUVEC by FACS.


Specifications

  • Immunogen
  • Recombinant human integrin-α5 protein-Fc
  • Host Species
  • Human
  • Type
  • Human antibody
  • Specificity
  • Human
  • Clone
  • 22B5
  • Applications
  • ELISA, FC, Block, ADCC
  • Related Disease
  • Metastatic melanoma

Applications

  • Application Notes
  • This antibody has been tested for use in Flow Cytometry, Blocking and Antibody-dependent Cellular Cytotoxicity Assay.

Target

  • Alternative Names
  • Integrin α5β1; GPV/IIIa; GPV/IIa

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Mouse Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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