Anti-Itgae immunotoxin M290 (IgG)-Sap (CAT#: AGTO-G046S)
This immunotoxin was achieved by conjugating/fusing the Anti-Itgae monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Itgae-expressing cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of organ allograft rejection and graft-versus-host disease.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows distinct cytoplasmic positivity in intra-epithelial lymphocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36313/ihc_selected.jpg
(Immunohistochemical staining of human small intestine shows distinct cytoplasmic positivity in intra-epithelial lymphocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36313/ihc_selected.jpg
Figure 2 High expression in small intestine
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_4_2_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_4_2_selected.jpg
Figure 3 Low expression in cerebral cortex
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_B_9_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_B_9_5_val_selected.jpg
Figure 4 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_8_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_8_3.jpg
Figure 5 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_8_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_8_5.jpg
Figure 6 RNA cell line category: Cell line enriched (MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000083457-ITGAE
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000083457-ITGAE
Specifications
- Host Species
- Rat
- Species Reactivity
- Mouse
- Clone
- M290
- Molecule Class
- IgG-Sap
- Toxin Description
- Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- organ allograft rejection and graft-versus-host disease
Target
- Alternative Names
- ITGAE; integrin alpha E, epithelial-associated; CD103; aM290; alpha-E1; A530055J10; alpha-M290; integrin alpha-E; integrin alpha M290; saporin; saporin-6; saporin-S43; SAP
- Gene ID
- 16407
- UniProt ID
- Q60677
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1726z | Mouse Anti-ITGAE Recombinant Antibody (clone 23B3) | WB, FC, IHC, IP | Mouse IgG1, κ |
| MOB-0363MZ | Recombinant Mouse Anti-Human Integrin, Alpha E (antigen CD103, Human Mucosal Lymphocyte antigen 1; Alpha Polypeptide) Antibody (clone Cer-ACT9) | ELISA | Mouse antibody |
| MRO-0851-CN | Recombinant Rabbit Anti-ITGAE Monoclonal Antibody (CBACN-312) | IHC | Rabbit IgG |
| FN-104CQ | Recombinant Rat Anti-ITGAE Antibody (M290) | IF, Neut, FC | Rat IgG2a |
| FAMAB-1581CQ | Mouse Anti-ITGAE Recombinant Antibody (clone OX62) | Depletion, IP, MACS, WB, FC, IF, IHC-Fr | Mouse IgG1 |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-741LC | Anti-human ITGAE Recombinant Antibody (5E4) (TAB-741LC) | ELISA, FC | |
| TAB-742LC | Anti-human ITGAE Recombinant Antibody (3G6) (TAB-742LC) | ELISA, FC | |
| TAB-743LC | Anti-human ITGAE Recombinant Antibody (8D5) (TAB-743LC) | ELISA, FC | |
| TAB-741LC-S(P) | Anti-human ITGAE scFv Fragment (5E4) | ELISA, FC | |
| TAB-742LC-S(P) | Anti-human ITGAE scFv Fragment (3G6) | ELISA, FC |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-744LC | Anti-human ITGAE Recombinant Antibody (5E4 (IgG1)) (TAB-744LC) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-744LC-S(P) | Anti-human ITGAE scFv Fragment (5E4 (IgG1)) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-745LC-S(P) | Anti-human ITGAE scFv Fragment (3G6 (IgG1)) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-744LC-F(E) | Anti-human ITGAE Fab Fragment (5E4 (IgG1)) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-745LC-F(E) | Anti-human ITGAE Fab Fragment (3G6 (IgG1)) | ELISA, FC | Chimeric antibody (mouse/human) |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0296MZ | Chicken Anti-ITGAE Polyclonal IgY | WB | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1558CQ | Recombinant Rat Anti-Itgae Antibody (MAB0828) | BL, FC, IHC-Fr, IP | IgG2 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1877 | Hi-Affi™ Recombinant Rabbit Anti-ITGAE Monoclonal Antibody (DS1877AB) | WB | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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