Anti-KDR immunotoxin (IgG1)-PE

CAT#: AGTO-G047E

This immunotoxin was achieved by conjugating/fusing the Anti-KDR monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for inhibiting tumor angiogenesis.

Gene Expression
Figure 1 IF staining of human cell line HEL Figure 2 Placenta Figure 3 Colon Figure 4 Kidney Figure 5 Testis Figure 6 RNA cell line category: Group enriched (HUVEC TERT2, TIME)

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Molecule Class
  • IgG1-PE
  • Toxin Description
  • Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • tumor angiogenesis

Target

  • Alternative Names
  • KDR; kinase insert domain receptor; FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE73
REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS
Inquiry
Navs

Customer Review

Submit a review or a question

There are currently no Customer reviews or questions for AGTO-G047E. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Article title:
DOI/PubMed URL:
Email:
Name:

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "KDR"

Select a product category from the dropdown menu below to view related products.

CAT Product Name Application Type
IAB-B066(A) Recombinant Anti-human KDR Intrabody [(D-Arg)9] FC, IF, FuncS scFv-(D-Arg)9
IAB-B066(G) Recombinant Anti-human KDR Intrabody [+36 GFP] CO-IP, FuncS scFv-(+36GFP)
IAB-B066(T) Recombinant Anti-human KDR Intrabody [Tat] IF, ELISA, FuncS scFv-Tat
CAT Product Name Application Type
TAB-202 Humanized Anti-KDR Recombinant Antibody (clone Alacizumab); di - Fab' Fragment IF, IP, Neut, FuncS, ELISA, FC, ICC Humanized (from mouse) di - Fab'
TAB-411CQ Anti-Human KDR Recombinant Antibody (HLX06) ELISA Humanized antibody
TAB-411CQ-S(P) Anti-Human KDR Recombinant Antibody scFv Fragment (HLX06) ELISA Humanized antibody
TAB-411CQ-F(E) Anti-Human KDR Recombinant Antibody Fab Fragment (HLX06) ELISA Humanized antibody
CAT Product Name Application Type
BRD-0624MZ Chicken Anti-VEGFR-2 Polyclonal IgY IHC, WB Chicken antibody
BRD-0709MZ Chicken Anti-KDR Polyclonal IgY WB Chicken antibody
CAT Product Name Application Type
AFC-TAB-079 Afuco™ Anti-KDR ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-079) IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody
CAT Product Name Application Type
HPAB-0298-YJ-VHH Recombinant Human Anti-KDR Nano Antibody (HPAB-0298-YJ-VHH) Inhib Human VHH
CAT Product Name Application Type
VS-0125-FY19 Human Anti-KDR (clone clone 6.64) scFv-Fc Chimera IHC, ELISA, Inhib Human IgG1, scFv-Fc
VS-0325-FY84 Human Anti-KDR (clone 1121B) scFv-Fc Chimera FC Human IgG1, scFv-Fc
CAT Product Name Application Type
VS-0425-YC463 Recombinant Anti-KDR Vesicular Antibody, EV Displayed (VS-0425-YC463) ELISA, FC, Inhib, Cell-uptake
CAT Product Name Application Type
VS-0525-XY3760 Anti-KDR Immunohistochemistry Kit IHC
Specific Inquiry
Go to compare Add to compare

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Go to compare

Go to compare