Recombinant Anti-human KDR Intrabody [Tat]
CAT#: IAB-B066(T)
Recombinant anti-KDR intrabody in fusion with HIV Tat works within cells to block the transport of KDR, expressed in E. coli cells. It can inhibit VEGF induced signalling and affect the maturation of the receptor.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73577/1825_D8_31_cr5ac340707076b_selected.jpg
Normal Tissue
Figure 2 Placenta
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_2_7_val_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_8_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128052-KDR
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Specifications
- Immunogen
- human kinase insert domain receptor
- Host Species
- mouse
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Can be useful in applications such as: Immunofluorescence; Enzyme-linked Immunosorbent Assay; Functional studies
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Target
- Alternative Names
- KDR; kinase insert domain receptor; FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor; kina
- Gene ID
- 3791
- UniProt ID
- A0A024RD88
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-411CQ | Anti-Human KDR Recombinant Antibody (HLX06) | ELISA | Humanized antibody |
| TAB-411CQ-S(P) | Anti-Human KDR Recombinant Antibody scFv Fragment (HLX06) | ELISA | Humanized antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-322CQ | Anti-Human KDR Recombinant Antibody (AK404R) | ELISA, WB, Inhib | Human antibody |
| TAB-325CQ | Human Anti-KDR Recombinant Antibody (TAB-325CQ) | ELISA, FC | Human IgG1, κ |
| TAB-329CQ | Human Anti-KDR Recombinant Antibody (TAB-329CQ) | ELISA, WB, Inhib | Human IgG1, κ |
| TAB-330CQ | Mouse Anti-KDR Recombinant Antibody (TAB-330CQ) | Inhib | Mouse IgG |
| TAB-333CQ | Human Anti-KDR Recombinant Antibody (TAB-333CQ) | ELISA | Human IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-326CQ-S(P) | Rat Anti-Kdr Recombinant Antibody; scFv Fragment (TAB-326CQ-S(P)) | ELISA, FC, WB | Rat scFv |
| TAB-331CQ-S(P) | Anti-Human KDR Recombinant Antibody scFv Fragment (6.64) | ELISA, FC, IHC | |
| TAB-326CQ-F(E) | Rat Anti-Kdr Recombinant Antibody; Fab Fragment (TAB-326CQ-F(E)) | ELISA, FC, WB | Rat Fab |
| TAB-331CQ-F(E) | Anti-Human KDR Recombinant Antibody Fab Fragment (6.64) | ELISA, FC, IHC | |
| TAB-332CQ-F(E) | Anti-Human KDR Recombinant Antibody Fab Fragment (4.13) | ELISA, FC, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0624MZ | Chicken Anti-VEGFR-2 Polyclonal IgY | IHC, WB | Chicken antibody |
| BRD-0709MZ | Chicken Anti-KDR Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1619CQ | Recombinant Mouse Anti-KDR Antibody (23B31) | WB, IP, FC, Neut | |
| NEUT-1620CQ | Recombinant Rat Anti-Kdr Antibody (CBL840) | ELISA(Cap), Neut | IgG2a |
| NEUT-1621CQ | Recombinant Rat Anti-Kdr Antibody (CBL880) | Neut, WB | IgG2 |
| NEUT-1622CQ | Recombinant Mouse Anti-KDR Antibody (6B11) | WB, Neut | IgG1 |
| NEUT-1623CQ | Recombinant Mouse Anti-KDR Antibody (CBL505) | FC, CyTOF, Neut | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1927 | Hi-Affi™ Recombinant Rabbit Anti-KDR Monoclonal Antibody (DS1927AB) | IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0097-YC-F(E) | Rabbit Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-0097-YC-F(E)) | ELISA, FuncS | Rabbit Fab |
| HPAB-0098-YC-F(E) | Rabbit Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-0098-YC-F(E)) | ELISA, FuncS | Rabbit Fab |
| HPAB-0099-YC-F(E) | Rabbit Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-0099-YC-F(E)) | ELISA, FuncS | Rabbit Fab |
| HPAB-0251-FY-F(E) | Human Anti-KDR Recombinant Antibody Fab Fragment (HPAB-0251-FY-F(E)) | ELISA | Human Fab |
| HPAB-0252-FY-F(E) | Human Anti-KDR Recombinant Antibody Fab Fragment (HPAB-0252-FY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0251-FY | Human Anti-KDR Recombinant Antibody (HPAB-0251-FY) | ELISA | Human IgG1 |
| HPAB-0252-FY | Human Anti-KDR Recombinant Antibody (HPAB-0252-FY) | ELISA | Human IgG1 |
| HPAB-0253-FY | Human Anti-KDR Recombinant Antibody (HPAB-0253-FY) | ELISA | Human IgG1 |
| HPAB-0254-FY | Human Anti-KDR Recombinant Antibody (HPAB-0254-FY) | ELISA | Human IgG1 |
| HPAB-0255-FY | Human Anti-KDR Recombinant Antibody (HPAB-0255-FY) | ELISA | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-079 | Afuco™ Anti-KDR ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-079) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0154-YC-S(P) | Mouse Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-N0154-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-1279-FY-F(E) | Mouse Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-1279-FY-F(E)) | ELISA, FC, Inhib | Mouse Fab |
| HPAB-1280-FY-F(E) | Mouse Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-1280-FY-F(E)) | ELISA, FC, Inhib | Mouse Fab |
| HPAB-1281-FY-F(E) | Mouse Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-1281-FY-F(E)) | ELISA, FC, Inhib | Mouse Fab |
| HPAB-1282-FY-F(E) | Mouse Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-1282-FY-F(E)) | ELISA, FC, Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0298-YJ-VHH | Recombinant Human Anti-KDR Nano Antibody (HPAB-0298-YJ-VHH) | Inhib | Human VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| MHC-YF772 | H-2Db/Human VEGFR2/KDR fragment 1 (FSNSTNDILI) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY19 | Human Anti-KDR (clone clone 6.64) scFv-Fc Chimera | IHC, ELISA, Inhib | Human IgG1, scFv-Fc |
| VS-0325-FY84 | Human Anti-KDR (clone 1121B) scFv-Fc Chimera | FC | Human IgG1, scFv-Fc |
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