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Recombinant Anti-KRAS Single Domain Antibody (KRAS_13) (HPAB-0346-YC-VHH)

KRAS is a Kirsten ras oncogene homolog from the mammalian ras gene family. KRAS encodes a protein that is a member of the small GTPase superfamily. The protein is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas, and colorectal carcinoma. Anti-KRAS sdAbs were developed to target wild-type and mutated KRAS (G12D) in order to disrupt its role in malignant cells such as, for example, cells involved in colorectal cancer, pancreatic cancer, biliary tract cancer, lung cancer, leukemias, and other metastatic malignancies.      

  • Datasheet

Specifications
Host
Camelid
Derivation
Ribosome display
Type
Camel VHH
Specificity
Human KRAS
Species Reactivity
Human
Clone
KRAS_13
Applications
Cytotoxicity, Blocking
Related Disease
Cancer, Abnormal cellular proliferation
Target
Alternative Names
NS; NS3; CFC2; RALD; KRAS1; KRAS2; RASK2; KI-RAS
Entrez Gene ID
3845
UniProt ID
P01116

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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