Recombinant Camelid Anti-KRAS Single Domain Antibody (HPAB-0346-YC-VHH) (CAT#: HPAB-0346-YC-VHH)
KRAS is a Kirsten ras oncogene homolog from the mammalian ras gene family. KRAS encodes a protein that is a member of the small GTPase superfamily. The protein is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas, and colorectal carcinoma. Anti-KRAS sdAbs were developed to target wild-type and mutated KRAS (G12D) in order to disrupt its role in malignant cells such as, for example, cells involved in colorectal cancer, pancreatic cancer, biliary tract cancer, lung cancer, leukemias, and other metastatic malignancies.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_B_9_5.jpg
(Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_B_9_5.jpg
Figure 2 Colon
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_A_8_3.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_A_8_3.jpg
Figure 3 Kidney
(Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_A_7_5.jpg
(Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_A_7_5.jpg
Figure 4 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_A_8_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_A_8_8.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000133703-KRAS
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000133703-KRAS
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000133703-KRAS
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000133703-KRAS
Specifications
- Host Species
- Camelid
- Derivation
- Ribosome display
- Type
- Camel VHH
- Specificity
- Human KRAS
- Species Reactivity
- Human
- Clone
- HPAB-0346-YC-VHH
- Applications
- Cytotoxicity, Blocking
- Related Disease
- Cancer, Abnormal cellular proliferation
Target
- Alternative Names
- NS; NS3; CFC2; RALD; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B
- Gene ID
- 3845
- UniProt ID
- P01116
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1225z | Mouse Anti-KRAS Recombinant Antibody (clone 23A6) | WB, ELISA, FC, ICC, IF | Mouse IgG2b, κ |
| MOB-1757MZ | Recombinant Mouse Anti-Human KRAS Antibody | FC, IHC-P, WB | Mouse antibody |
| MRO-2154-CN | Rabbit Anti-KRAS Polyclonal Antibody (MRO-2154-CN) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-N0159-YC | Human Anti-KRAS Recombinant Antibody (HPAB-N0159-YC) | ELISA | Human IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1973 | Hi-Affi™ Recombinant Rabbit Anti-KRAS Monoclonal Antibody (DS1973AB) | WB, ICC, IP | IgG |
| MOR-0031-FY | Rabbit Anti-KRAS Recombinant Antibody (clone AFY0002) | IHC-P, WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0159-YC-S(P) | Human Anti-KRAS Recombinant Antibody; scFv Fragment (HPAB-N0159-YC-S(P)) | ELISA | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0159-YC-F(E) | Human Anti-KRAS Recombinant Antibody; Fab Fragment (HPAB-N0159-YC-F(E)) | ELISA | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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