Afuco™ Anti-Human L1CAM ADCC Recombinant Antibody, ADCC Enhanced
CAT#: AFC-458CL
Anti-L1CAM ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. The monoclonal antibody can bind to LlCAM that is a surface antigen of the cancer cell, and suppress the activity of LlCAM, thereby inhibiting the growth and metastasis of the cancer cells. More specifically, the monoclonal antibody binds to an IgI domain of LlCAM, and thus it can be used for diagnosis or treatment of cancers expressing LlCAM.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/208_G1_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/207_G1_1_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/206_G1_1_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuropil
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/27469_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Peripheral nerve/ganglion
Staining:
High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/27469_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Collecting ducts
Staining:
High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:
High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/27469_A_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (BJ hTERT+, BJ hTERT+ SV40 Large T+ RasG12V, HeLa, RH-30, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198910-L1CAM
❮
❯
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >98% by SDS-PAGE and HPLC analysis
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "L1CAM"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0635CL | Human Anti-L1CAM Recombinant Antibody (TAB-0635CL) | WB, IF, IHC, PK, ELISA, FC | Human antibody |
| TAB-0635CL-S(P) | Human Anti-L1CAM Recombinant Antibody; scFv Fragment (TAB-0635CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0635CL-F(E) | Human Anti-L1CAM Recombinant Antibody; Fab Fragment (TAB-0635CL-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0636CL | Anti-Human L1CAM Recombinant Antibody (L1-9.3) | WB, IHC, ELISA, FC | |
| TAB-0636CL-S(P) | Anti-Human L1CAM Recombinant Antibody scFv Fragment (L1-9.3) | WB, FC | |
| TAB-0636CL-F(E) | Anti-Human L1CAM Recombinant Antibody Fab Fragment (L1-9.3) | WB, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1999 | Hi-Affi™ Recombinant Rabbit Anti-L1CAM Monoclonal Antibody (DS1999AB) | ELISA, WB | IgG |
| MOR-4297 | Hi-Affi™ Recombinant Rabbit Anti-L1CAM Monoclonal Antibody (SI384DS) | FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0191-YC-S(P) | Human Anti-L1CAM Recombinant Antibody (clone G6); scFv Fragment | ELISA, IF, WB | Human scFv |
| FAMAB-0192-YC-S(P) | Human Anti-L1CAM Recombinant Antibody (clone H2); scFv Fragment | ELISA, IF, WB | Human scFv |
| HPAB-0827-CN-S(P) | Human Anti-L1CAM Recombinant Antibody; scFv Fragment (HPAB-0827-CN-S(P)) | WB, ELISA, IHC, FC | Human scFv |
| HPAB-0828-CN-S(P) | Human Anti-L1CAM Recombinant Antibody; scFv Fragment (HPAB-0828-CN-S(P)) | WB, ELISA, IHC, FC | Human scFv |
| HPAB-J0160-YC-S(P) | Human Anti-L1CAM Recombinant Antibody (clone Ab4); scFv Fragment | ELISA, FC, WB, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0191-YC-F(E) | Human Anti-L1CAM Recombinant Antibody (clone G6); Fab Fragment | ELISA, IF, WB | Human Fab |
| FAMAB-0192-YC-F(E) | Human Anti-L1CAM Recombinant Antibody (clone H2); Fab Fragment | ELISA, IF, WB | Human Fab |
| HPAB-0561-YJ-F(E) | Mouse Anti-L1CAM Recombinant Antibody (clone A10-A3); Fab Fragment | ELISA, FC, FuncS | Mouse Fab |
| HPAB-0562-YJ-F(E) | Human Anti-L1CAM Recombinant Antibody (clone cA10-A3); Fab Fragment | ELISA, FC, FuncS | Chimeric (mouse/human) Fab |
| HPAB-0563-YJ-F(E) | Human Anti-L1CAM Recombinant Antibody (clone HzA10A3-2.1); Fab Fragment | ELISA, FC, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0827-CN | Human Anti-L1CAM Recombinant Antibody (HPAB-0827-CN) | WB, ELISA, IHC, FC | Humanized IgG1, κ |
| HPAB-0828-CN | Human Anti-L1CAM Recombinant Antibody (HPAB-0828-CN) | WB, ELISA, IHC, FC | Humanized IgG1, κ |
| MRO-0911-CN | Recombinant Rabbit Anti-L1CAM Monoclonal Antibody (JM11-05) | WB, IHC | Rabbit IgG |
| MRO-2060-CN | Rabbit Anti-L1CAM Polyclonal Antibody (MRO-2060-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-FY2760 | Mouse Anti-L1CAM Recombinant Antibody (VS3-FY2760) | FC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC65 | Rabbit Anti-L1CAM Antibody (VS-0924-YC65) - Cancer Stem Cell Marker | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1223 | Anti-L1CAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY3907 | Anti-Mouse L1CAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY3906 | Anti-Human L1CAM Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC638 | CytoStream™ Rabbit Anti-L1CAM Recombinant Antibody (VS13-YC638) | FC, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC318 | Recombinant Anti-L1CAM Vesicular Antibody, EV Displayed (VS-0425-YC318) | ELISA, FC, Cell-uptake |
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