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    Mouse Anti-LOXL2 Recombinant Antibody (HPAB-0160-LSX) (CAT#: HPAB-0160-LSX)

    This product is a recombinant mouse antibody that recognizes LOXL2. The antibody was expressed in mammalian cells with chemically defined culture media and was purified by affinity chromatography.

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    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36257/847_B2_2_selected.jpg
    Figure 2 IF staining of human cell line A549
    Figure 2 IF staining of human cell line A549
    (Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56542/985_A11_1_selected.jpg
    Figure 3 IHC staining of human pancreas
    Figure 3 IHC staining of human pancreas
    (Immunohistochemical staining of human pancreas shows moderate positivity in exocrine cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25848/ihc_selected.jpg
    Figure 4 IF staining of human cell line U-251 MG
    Figure 4 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36257/752_B2_1_red_green.jpg
    Normal Tissue
    Figure 5 Cerebral cortex
    Figure 5 Cerebral cortex
    (Neuropil
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25848/56663_B_7_5.jpg
    Figure 6 Colon
    Figure 6 Colon
    (Glandular cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Peripheral nerve/ganglion
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25848/56663_A_9_3.jpg
    Figure 7 Liver
    Figure 7 Liver
    (Hepatocytes
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25848/56663_A_8_4.jpg
    Figure 8 Testis
    Figure 8 Testis
    (Leydig cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25848/56663_A_4_6.jpg
    Figure 9 Placenta
    Figure 9 Placenta
    (Decidual cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25848/56663_A_3_7.jpg
    RNA Expression
    Figure 10 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+ RasG12V, fHDF/TERT166, TIME, U-87 MG)
    Figure 10 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+ RasG12V, fHDF/TERT166, TIME, U-87 MG)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134013-LOXL2

    Specifications

    • Host Species
    • Mouse
    • Derivation
    • Mouse
    • Type
    • Mouse IgG
    • Specificity
    • Human LOXL2
    • Species Reactivity
    • Human
    • Applications
    • ELISA
    • Related Disease
    • Fibrotic condition

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • LOR2; WS9-14

    Related Resources

    • Citations

    Fan, Zhiyong, et al. "LOXL2 upregulates hypoxia-inducible factor-1α signaling through Snail-FBP1 axis in hepatocellular carcinoma cells." Oncology reports 43.5 (2020): 1641-1649. https://doi.org/10.3892/or.2020.7541

    This research investigates the role of Lysyl oxidase-like 2 (LOXL2) in hepatocellular carcinoma (HCC) progression, focusing on its regulatory effect on hypoxia-inducible factor-1α (HIF-1α) signaling. The study demonstrates that LOXL2 inhibits the expression of fructose-1,6-biphosphatase (FBP1) in a Snail-dependent manner, which subsequently enhances glycolysis in HCC cell lines. Importantly, the research reveals that intracellular LOXL2 activity, rather than extracellular LOXL2, is responsible for upregulating HIF-1α/VEGF signaling pathways through the Snail-FBP1 axis. This effect was abolished when using LOXL2 inhibitors, suggesting therapeutic potential.
    Creative Biolabs provided an anti-human LOXL2 therapeutic antibody (Simtuzumab; CAT#: HPAB-0160-LSX) that was used to evaluate the binding between the antibody and extracellular LOXL2 protein in immunoprecipitation assays. This antibody helped researchers distinguish between the roles of intracellular and extracellular LOXL2, leading to the critical finding that intracellular LOXL2 activity is primarily responsible for Snail upregulation and subsequent metabolic changes in HCC cells, which represents a significant advancement in understanding potential therapeutic targets for hepatocellular carcinoma.

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    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "LOXL2"

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    CAT Product Name Application Type
    MOB-1260z Mouse Anti-LOXL2 Recombinant Antibody (clone 19H6) WB, IP, IF, ELISA Mouse IgG2b, κ
    HPAB-0161-LSX Human Anti-LOXL2 Recombinant Antibody (HPAB-0161-LSX) ELISA, WB, RIA Human IgG
    HPAB-0162-LSX Mouse Anti-LOXL2 Recombinant Antibody (HPAB-0162-LSX) ELISA, WB, RIA Mouse IgG
    MRO-0937-CN Recombinant Rabbit Anti-LOXL2 Monoclonal Antibody (JU32-53) WB, IF, IHC, FC Rabbit IgG
    ZG-0447U Rabbit Anti-LOXL2 Recombinant Antibody (clone 2E5) ELISA, WB, IHC, IF, FC Rabbit IgG

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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