Mouse Anti-LRP6 Recombinant Antibody scFv Fragment (PSBC-205) (CAT#: PSBC-205)
Recombinant mouse antibody scFv Fragment is capable of binding to LRP6. This antibody enhanced Wnt dependent TCF reporter activation and antagonized DKK1 dependent inhibition of Wnt3A signaling, suggesting a role in modulation of LRP6 function. It completely protected LRP6 from DKK1 dependent internalization.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IHC staining of human colon
(Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/ihc_selected.jpg
(Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/ihc_selected.jpg
Figure 2 IHC staining of human kidney
(High expression. RNA expression: 4.4 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/ihc_selected.jpg
(High expression. RNA expression: 4.4 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/ihc_selected.jpg
Figure 3 IHC staining of human lymph node
(Low expression. RNA expression: 0.8 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/62204_A_7_8_val_selected.jpg
(Low expression. RNA expression: 0.8 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/62204_A_7_8_val_selected.jpg
Figure 4 Cerebral cortex
(Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12171_B_8_5.jpg
(Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12171_B_8_5.jpg
Figure 5 Liver
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_8_4.jpg
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_8_4.jpg
Figure 6 Testis
(Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_4_6.jpg
(Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_4_6.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000070018-LRP6
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000070018-LRP6
Specifications
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- Mouse scFv
- Specificity
- Human LRP6
- Species Reactivity
- Human
- Applications
- ELISA, WB, FC
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- LRP6; low density lipoprotein receptor-related protein 6; ADCAD2; low-density lipoprotein receptor-related protein 6; LRP-6
- Gene ID
- 4040
- UniProt ID
- O75581
Related Resources
Canonical Wnt Signaling Pathway
JAK-STAT Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Hepatocellular Carcinoma
Pancreatic Cancer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Mouse Antibody Products
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IgG Antibody Products
Single Domain Antibody Products
ScFv-Fc Chimera Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0092CL | Mouse Anti-LRP6 Recombinant Antibody (TAB-0092CL) | ELISA, FC, Inhib, FuncS, Internalization | |
| TAB-0093CL | Mouse Anti-LRP6 Recombinant Antibody (TAB-0093CL) | ELISA, FC, Inhib, FuncS, Internalization | |
| TAB-0094CL | Mouse Anti-LRP6 Recombinant Antibody (TAB-0094CL) | ELISA, FC, Inhib, FuncS, Internalization | |
| TAB-0095CL | Mouse Anti-LRP6 Recombinant Antibody (TAB-0095CL) | ELISA, FC, Inhib, FuncS, Internalization | |
| TAB-0096CL | Mouse Anti-LRP6 Recombinant Antibody (TAB-0096CL) | ELISA, FC, Inhib, FuncS, Internalization |
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