Human Anti-MAPT Recombinant Antibody (clone pT231/pS235_1); Fab Fragment (CAT#: PFBZ-196)
Recombinant Chimeric (Chicken/Human) Antibody (pT231/pS235_1) is capable of binding to MAPT. The fab exhibits novel complementarity determining region (CDR) structures with a "bowl-like" conformation in CDR-H2 that tightly and specifically interacts with the phospho-Thr-231 phosphate group, as well as a long, disulfide-constrained CDR-H3 that mediates peptide recognition.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line MCF7 shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48895/1070_E6_2_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48895/1070_E6_2_selected.jpg
Figure 2 IF staining of human cell line BJ
(Immunohistochemical staining of human appendix shows strong positivity in peripheral ganglia and nerve fibers.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69524/156431_A_3_2_selected.jpg
(Immunohistochemical staining of human appendix shows strong positivity in peripheral ganglia and nerve fibers.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69524/156431_A_3_2_selected.jpg
Figure 3 Cerebral cortex
(Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_B_8_5.jpg
(Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_B_8_5.jpg
Figure 4 Colon
(Endocrine cells
Staining:
Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_3.jpg
(Endocrine cells
Staining:
Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_3.jpg
Figure 5 Kidney
(Proximal tubules (cell body)
Staining:
Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_5.jpg
(Proximal tubules (cell body)
Staining:
Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_5.jpg
Figure 6 RNA cell line category: Group enriched (HDLM-2, SCLC-21H, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
Figure 6 RNA cell line category: Group enriched (HDLM-2, SCLC-21H, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
Specifications
- Immunogen
- Human microtubule-associated protein tau
- Host Species
- Human
- Derivation
- Chimeric (chicken/human)
- Type
- Chimeric (chicken/human) Fab
- Specificity
- Human MAPT
- Species Reactivity
- Human
- Clone
- pT231/pS235_1
- Applications
- ELISA, WB
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- MAPT; microtubule-associated protein tau; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; protein phosphatase 1, regulatory subunit 103; G protein beta1/gamma2 subunit-interacting factor 1;
- Gene ID
- 4137
- UniProt ID
- P10636
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-305 | Chicken Anti-MAPT Recombinant Antibody | WB, ELISA, FuncS | Chicken IgY |
| MRO-2209-CN | Rabbit Anti-MAPT Polyclonal Antibody (MRO-2209-CN) | WB, IF, IHC | Rabbit IgG |
| HPAB-N0170-YC | Human Anti-MAPT Recombinant Antibody (HPAB-N0170-YC) | ELISA, Inhib | Humanized IgG |
| HPAB-N0171-YC | Human Anti-MAPT Recombinant Antibody (HPAB-N0171-YC) | ELISA, FuncS | Human IgG4 |
| HPAB-N0172-YC | Mouse Anti-MAPT Recombinant Antibody (HPAB-N0172-YC) | ELISA | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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