Anti-Human MCAM Recombinant Antibody (ABX-MA1)
CAT#: TAB-516CL
Recombinant Human monoclonal antibody expressed in CHO binding to Human MCAM. ABX-MA1 is a fully human anti-MUC18 antibody relates to angiogenesis, tumor growth, and metastasis. ABX-MA1 treatment of melanoma cells in vitro significantly inhibited the promoter and collagenase activity of matrix metalloproteinase 2, resulting in decreased invasion through Matrigel-coated filters. ABX-MA1 directly disrupted the tube-like formation by HUVECs in an in vitro vessel formation assay. Collectively, these results point to usefulness of ABX-MA1 as a modality to treat melanoma either alone or in combination with conventional chemotherapy or other antitumor agents.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2147/if_selected.jpg
Normal Tissue
Figure 2 Soft tissue
Fibroblasts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_B_2_7.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Peritubular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Low Intensity: Weak Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8848/24112_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, TIME, WM-115)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000076706-MCAM
❮
❯
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- WB, FuncS
- Related Disease
- Melanoma
Product Property
- Purity
- >95% as judged by SDS-polyacrylamide gel electrophoresis
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay and Western Blot. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- MCAM; melanoma cell adhesion molecule; CD146; MUC18; cell surface glycoprotein MUC18; Gicerin; melanoma adhesion molecule; cell surface glycoprotein P1H12; melanoma-associated antigen A32; melanoma-associated antigen MUC18; S-endo 1 endothelial-associated
- Gene ID
- 4162
- UniProt ID
- A0A024R3I5
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "MCAM"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-441MZ | Mouse Anti-MCAM Recombinant Antibody (TAB-441MZ) | FC, FuncS | Mouse IgG1 |
| TAB-441MZ-S(P) | Mouse Anti-MCAM Recombinant Antibody; scFv Fragment (TAB-441MZ-S(P)) | FC, WB, IHC | Mouse scFv |
| TAB-441MZ-F(E) | Mouse Anti-MCAM Recombinant Antibody; Fab Fragment (TAB-441MZ-F(E)) | FC, WB, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-442MZ | Human Anti-MCAM Recombinant Antibody (TAB-442MZ) | FC, WB, IHC | Chimeric (Mouse/Human) IgG1 |
| TAB-443MZ | Human Anti-MCAM Recombinant Antibody (TAB-443MZ) | FC, WB, IHC | Chimeric (Mouse/Human) IgG3 |
| TAB-442MZ-S(P) | Human Anti-MCAM Recombinant Antibody; scFv Fragment (TAB-442MZ-S(P)) | FC, WB, IHC | Human scFv |
| TAB-442MZ-F(E) | Human Anti-MCAM Recombinant Antibody; Fab Fragment (TAB-442MZ-F(E)) | FC, WB, IHC | Chimeric (Mouse/Human) Fab |
| TAB-443MZ-F(E) | Human Anti-MCAM Recombinant Antibody; Fab Fragment (TAB-443MZ-F(E)) | FC, WB, IHC | Chimeric (Mouse/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-444MZ | Anti-Human MCAM Recombinant Antibody (TAB-444MZ) | ELISA | Humanized antibody |
| TAB-444MZ-S(P) | Anti-Human MCAM Recombinant Antibody scFv Fragment (TAB-444MZ-S(P)) | ELISA | Humanized antibody |
| TAB-444MZ-F(E) | Anti-Human MCAM Recombinant Antibody Fab Fragment (TAB-444MZ-F(E)) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2188 | Hi-Affi™ Recombinant Rabbit Anti-MCAM Monoclonal Antibody (DS2188AB) | ICC, IF, IHC-Fr, WB, IP, IHC-P, ICC, FC | IgG |
| MOR-4644 | Hi-Affi™ Recombinant Rabbit Anti-MCAM Monoclonal Antibody (TH157DS) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0018-CN-S(P) | Mouse Anti-MCAM Recombinant Antibody (clone c264); scFv Fragment | FC | Mouse scFv |
| HPAB-0493LY-S(P) | Human Anti-MCAM Recombinant Antibody (clone H5L0); scfv Fragment | ELISA | Humanized scfv |
| HPAB-0494LY-S(P) | Human Anti-MCAM Recombinant Antibody (clone H10L2); scfv Fragment | ELISA | Humanized scfv |
| HPAB-0495LY-S(P) | Human Anti-MCAM Recombinant Antibody (clone H14L0); scfv Fragment | ELISA | Humanized scfv |
| HPAB-0204-YJ-S(P) | Human Anti-MCAM Recombinant Antibody (clone Hu2120); scFv Fragment | FC, Neut, Block, IF, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0493LY | Human Anti-MCAM Recombinant Antibody (clone H5L0) | ELISA | Humanized IgG1 |
| HPAB-0494LY | Human Anti-MCAM Recombinant Antibody (clone H10L2) | ELISA | Humanized IgG1 |
| HPAB-0495LY | Human Anti-MCAM Recombinant Antibody (clone H14L0) | ELISA | Humanized IgG1 |
| HPAB-0496LY | Human Anti-MCAM Recombinant Antibody (clone H11L3) | ELISA | Humanized IgG1 |
| HPAB-0497LY | Human Anti-MCAM Recombinant Antibody (clone H11L4) | ELISA | Humanized IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0493LY-F(E) | Human Anti-MCAM Recombinant Antibody (clone H5L0); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0494LY-F(E) | Human Anti-MCAM Recombinant Antibody (clone H10L2); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0495LY-F(E) | Human Anti-MCAM Recombinant Antibody (clone H14L0); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0496LY-F(E) | Human Anti-MCAM Recombinant Antibody (clone H11L3); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0497LY-F(E) | Human Anti-MCAM Recombinant Antibody (clone H11L4); Fab Fragment | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY185 | AbPlus™ Anti-MCAM Magnetic Beads (ScFv7) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY42 | Mouse Anti-MCAM (clone AA98) scFv-Fc Chimera | ELISA, FC, Inhib, IHC-Fr, WB, IP | Human IgG1, scFv-Fc |
| VS-0125-FY43 | Mouse Anti-MCAM (clone B6-11) scFv-Fc Chimera | WB, ELISA, IF | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC149 | Recombinant Anti-MCAM Vesicular Antibody, EV Displayed (VS-0425-YC149) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4291 | Anti-MCAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY4292 | Anti-Mouse MCAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY4293 | Anti-Rat MCAM Immunohistochemistry Kit | IHC |
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