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Human Anti-MET Recombinant Antibody (clone 5D5); Fab Fragment (CAT#: PFBL-271)

Recombinant Human Antibody (5D5) is capable of binding to MET, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-MET fab and CH1-3 region of human fab and a light chain (LC) encoding VL from anti-MET fab and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody potently inhibits HGF binding and receptor phosphorylation and signaling and has antibody-like pharmacokinetics and antitumor activity.


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Specific Inquiry
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  • Endotoxin:
  • Purity:
  • Gene Expression
  • Datasheet
  • MSDS
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Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55607/if_selected.jpg
Figure 2 IF staining of human cell line A-431
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/if_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18577/if_selected.jpg
Normal Tissue
Figure 4 Kidney
Figure 4 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_7_5.jpg
Figure 5 Testis
Figure 5 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)
Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105976-MET

Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • Human Fab
  • Specificity
  • Human MET
  • Species Reactivity
  • Human
  • Clone
  • 5D5
  • Applications
  • WB, Block, FuncS

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • MET; MET proto-oncogene; receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Immunotoxin

CAT Product Name Application Type
AGTO-G049E Anti-MET immunotoxin (Fab)-PE Cytotoxicity assay, Function study

ADCC Enhanced Antibody

CAT Product Name Application Type
PABZ-155 Afuco™ Anti-MET ADCC Recombinant Antibody (Onartuzumab), ADCC Enhanced ELISA, Neut ADCC enhanced antibody
AFC-TAB-H24 Afuco™ Anti-MET ADCC Recombinant Antibody (Emibetuzumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody

Human Antibody

CAT Product Name Application Type
TAB-0530CL Anti-Human MET Recombinant Antibody ELISA, FC, IF, FuncS
TAB-541LC-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-541LC-F(E)) WB Human Fab
TAB-003MZ-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-003MZ-F(E)) ELISA, FC, MTS assay Human Fab
TAB-004MZ-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-004MZ-F(E)) ELISA, FC, MTS assay Human Fab
TAB-005MZ-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-005MZ-F(E)) ELISA, FC, MTS assay Human Fab

Humanized Antibody

CAT Product Name Application Type
TAB-0332CL-S(P) Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0332CL-S(P)) ELISA Humanized scFv
TAB-0332CL-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0332CL-F(E)) ELISA Humanized Fab
TAB-0881CLV-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0881CLV-F(E)) ELISA, FuncS Humanized Fab
TAB-0883CLV-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0883CLV-F(E)) ELISA, FuncS Humanized Fab
TAB-0885CLV-S(P) Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0885CLV-S(P)) ELISA, FuncS Humanized scFv

Chimeric Antibody

CAT Product Name Application Type
TAB-002MZ Anti-Human MET Recombinant Antibody (MvDN30) IHC, PET imaging Chimeric antibody (mouse/human)
TAB-002MZ-S(P) Anti-Human MET Recombinant Antibody scFv Fragment (MvDN30) IHC, PET imaging Chimeric antibody (mouse/human)
TAB-002MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (MvDN30) IHC, PET imaging Chimeric antibody (mouse/human)
TAB-0880CLV Human Anti-MET Recombinant Antibody (TAB-0880CLV) ELISA, FuncS Chimeric (mouse/human) IgG1
TAB-0880CLV-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0880CLV-F(E)) ELISA, FuncS Chimeric (mouse/human) Fab

Mouse Antibody

CAT Product Name Application Type
TAB-011MZ-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-011MZ-S(P)) ELISA, WB, FC Mouse scFv
TAB-012MZ-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-012MZ-S(P)) ELISA, WB, FC Mouse scFv
TAB-027MZ-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-027MZ-S(P)) FC, WB, ELISA Mouse scFv
TAB-028MZ-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-028MZ-S(P)) FC, WB, ELISA Mouse scFv
TAB-029MZ-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-029MZ-S(P)) FC, WB, ELISA Mouse scFv

Recombinant Antibody

CAT Product Name Application Type
MOB-1226CT Recombinant Mouse anti-Human MET Monoclonal antibody (9G22) IHC-Fr, IHC-P
HPAB-0123-FY Camelid Anti-MET Recombinant Antibody (HPAB-0123-FY) ELISA Llama IgG1, λ
HPAB-1298LY Human Anti-MET Recombinant Antibody (HPAB-1298LY) ELISA, IP Human IgG2
HPAB-1299LY Human Anti-MET Recombinant Antibody (HPAB-1299LY) ELISA, IP Human IgG2
HPAB-1300LY Human Anti-MET Recombinant Antibody (HPAB-1300LY) ELISA, IP Human IgG2

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1726CQ Recombinant Rabbit Anti-MET Antibody (CBL1008) Neut IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2216 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (DS2216AB) ICC/IF, IHC-P, WB IgG
MOR-4519 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH27DS) WB, IF, ICC IgG
MOR-4645 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH158DS) WB, IF, ICC, FC, ELISA IgG
MOR-4694 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH208DS) WB, ELISA IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-1298LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1298LY-F(E)) ELISA, IP Human Fab
HPAB-1299LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1299LY-F(E)) ELISA, IP Human Fab
HPAB-1300LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1300LY-F(E)) ELISA, IP Human Fab
HPAB-1301LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1301LY-F(E)) ELISA, IP Human Fab
HPAB-1302LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1302LY-F(E)) ELISA, IP Human Fab

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-AP146-YC-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (HPAB-AP146-YC-S(P)) FC, IHC Mouse scFv
HPAB-AP147-YC-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (HPAB-AP147-YC-S(P)) FC, IHC Mouse scFv
HPAB-0714-FY-F(E) Mouse Anti-MET Recombinant Antibody (clone AB013); scFv Fragment ELISA Mouse scFv
HPAB-0117-WJ-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0117-WJ-S(P)) ELISA, WB Mouse scFv
HPAB-0486-FY-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0486-FY-S(P)) Inhib Mouse scFv

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-YF474 A*02:01/Human Hepatocyte growth factor receptor (YVDPVITSI) MHC Pentamer FCM

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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