Anti-Human MET Therapeutic Antibody (04E09) (CAT#: TAB-001MZ-VHH)

This antibody effectively inhibits the HGF binding to c-Met receptor in a dose-dependent manner and may be used for cancer therapy.

  • Published Data
  • Datasheet
  • MSDS
  • COA
Inhib

Figure 1 c-MET Phosphorylation Assay

Shows that Nanobodies of the invention inhibit HGF-dependent c-Met phosphorylation. The normalized ratio is plotted against the concentration of the Nanobody or the 5D5 Fab (triangle).

Agonist

Figure 2 Analysis of Agonistic Activity

Shows the analysis of agonistic activity of Nano body formats 04E09-9GS-Alb11 and 06C12-9GS-Alb11, and the comparison to 5D5 mAb and HGF

Inhib

Figure 3 Inhibition of HGF-dependent proliferation of BxPC3 cells

Shows that the Nanobody 04E09-9GS-Alb11 inhibits HGF-dependent proliferation of BXPC3 cells.

Inhib

Figure 4 Inhibition of HGF-dependent A549 cell migration

Shows that the c-Met blocking Nanobody 04E09 9GS-Alb 11 inhibits HGF-dependent migration of A549 cells.


Specifications

  • Host Species
  • Llama
  • Derivation
  • Phage display library
  • Type
  • Single domain antibody
  • Specificity
  • Human
  • Clone
  • 04E09
  • Applications
  • ELISA, Inhib, Agonist
  • Related Disease
  • Multiple myeloma, non-small cell lung cancer

Applications

  • Application Notes
  • The antibody was validated for Inhibition, Agonist. For details, refer to Published Data.

Target

  • Alternative Names
  • MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

See other products for "MET"

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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