Recombinant Humanized monoclonal antibody expressed in CHO binding to Human MET. ABT-700 is an anti-c-Met antibody with significant preclinical single-agent activity against MA human xenograft tumors. ABT-700 was well tolerated and appeared to have substantial single-agent activity. In this small cohort of gastric patients MA appears to be more common in treatment-refractory tumors than in primary untreated tumors, suggesting that screening efforts should focus on this treatment-refractory patient population.
Figure 1 Survival curves of mice with metastatic EBC1 tumors treated with ABT-700.
Primary tumors established after subcutaneous inoculation of EBC1 cells were surgically removed and ABT-700 at 10 mg/kg, Q21D, was administered with several schedules (start and end day) as shown. Growth of metastases in the lung caused death of animals and mortality was monitored over 530 days.
Wang, J., Goetsch, L., Tucker, L., Zhang, Q., Gonzalez, A., Vaidya, K. S., ... & Pestova, E. (2016). Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification. BMC cancer, 16(1), 105.
Figure 2 Immune-blots of signaling and apoptosis pathway molecules in SNU5 cells treated with 10 μg/mL ABT-700 for 24h.
Wang, J., Goetsch, L., Tucker, L., Zhang, Q., Gonzalez, A., Vaidya, K. S., ... & Pestova, E. (2016). Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification. BMC cancer, 16(1), 105.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G049E | Anti-MET immunotoxin (Fab)-PE | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
PABZ-155 | Afuco™ Anti-MET ADCC Recombinant Antibody (Onartuzumab), ADCC Enhanced | ELISA, Neut | ADCC enhanced antibody |
AFC-TAB-H24 | Afuco™ Anti-MET ADCC Recombinant Antibody (Emibetuzumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0332CL | Human Anti-MET Recombinant Antibody (TAB-0332CL) | ELISA | Humanized Antibody |
TAB-0332CL-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0332CL-F(E)) | ELISA | Humanized Fab |
TAB-026MZ | Anti-Human MET Recombinant Antibody (73R009) | WB | Humanized antibody |
TAB-026MZ-S(P) | Anti-Human MET Recombinant Antibody scFv Fragment (73R009) | WB | Humanized antibody |
TAB-026MZ-F(E) | Anti-Human MET Recombinant Antibody Fab Fragment (73R009) | WB | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0530CL-S(P) | Anti-Human MET Recombinant Antibody scFv Fragment | ELISA, FC, IF, FuncS | |
TAB-0530CL-F(E) | Anti-Human MET Recombinant Antibody Fab Fragment | ELISA, FC, IF, FuncS | |
TAB-038MZ-F(E) | Anti-Human MET Recombinant Antibody Fab Fragment (PGIA-4-A5) | WB, ELISA | Human antibody |
TAB-039MZ-F(E) | Anti-Human MET Recombinant Antibody Fab Fragment (PGIA-4-A8) | WB, ELISA | Human antibody |
TAB-040MZ-F(E) | Anti-Human MET Recombinant Antibody Fab Fragment (PGIA-5A1) | WB, ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-002MZ | Anti-Human MET Recombinant Antibody (MvDN30) | IHC, PET imaging | Chimeric antibody (mouse/human) |
TAB-002MZ-S(P) | Anti-Human MET Recombinant Antibody scFv Fragment (MvDN30) | IHC, PET imaging | Chimeric antibody (mouse/human) |
TAB-0880CLV | Human Anti-MET Recombinant Antibody (TAB-0880CLV) | ELISA, FuncS | Chimeric (mouse/human) IgG1 |
TAB-0880CLV-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0880CLV-F(E)) | ELISA, FuncS | Chimeric (mouse/human) Fab |
TAB-0880CLV-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-0880CLV-S(P)) | ELISA, FuncS | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-011MZ-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-011MZ-S(P)) | ELISA, WB, FC | Mouse scFv |
TAB-012MZ-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-012MZ-S(P)) | ELISA, WB, FC | Mouse scFv |
TAB-027MZ-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-027MZ-S(P)) | FC, WB, ELISA | Mouse scFv |
TAB-028MZ-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-028MZ-S(P)) | FC, WB, ELISA | Mouse scFv |
TAB-029MZ-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-029MZ-S(P)) | FC, WB, ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1726CQ | Recombinant Rabbit Anti-MET Antibody (CBL1008) | Neut | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2216 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (DS2216AB) | ICC/IF, IHC-P, WB | IgG |
MOR-4519 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH27DS) | WB, IF, ICC | IgG |
MOR-4645 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH158DS) | WB, IF, ICC, FC, ELISA | IgG |
MOR-4694 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH208DS) | WB, ELISA | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1298LY | Human Anti-MET Recombinant Antibody (HPAB-1298LY) | ELISA, IP | Human IgG2 |
HPAB-1299LY | Human Anti-MET Recombinant Antibody (HPAB-1299LY) | ELISA, IP | Human IgG2 |
HPAB-1300LY | Human Anti-MET Recombinant Antibody (HPAB-1300LY) | ELISA, IP | Human IgG2 |
HPAB-1301LY | Human Anti-MET Recombinant Antibody (HPAB-1301LY) | ELISA, IP | Human IgG2 |
HPAB-1302LY | Human Anti-MET Recombinant Antibody (HPAB-1302LY) | ELISA, IP | Human IgG2 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1298LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1298LY-F(E)) | ELISA, IP | Human Fab |
HPAB-1299LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1299LY-F(E)) | ELISA, IP | Human Fab |
HPAB-1300LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1300LY-F(E)) | ELISA, IP | Human Fab |
HPAB-1301LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1301LY-F(E)) | ELISA, IP | Human Fab |
HPAB-1302LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1302LY-F(E)) | ELISA, IP | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-N0177-YC-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-N0177-YC-S(P)) | ELISA, FC | Humanized scFv |
HPAB-0714-FY-F(E) | Mouse Anti-MET Recombinant Antibody (clone AB013); scFv Fragment | ELISA | Mouse scFv |
HPAB-1309-FY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1309-FY-F(E)) | ELISA | Human Fab |
HPAB-1310-FY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1310-FY-F(E)) | ELISA | Human Fab |
HPAB-1579-FY-F(E) | Human Anti-MET Recombinant Antibody (clone MET021); scFv Fragment | WB, ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-YF474 | A*02:01/Human Hepatocyte growth factor receptor (YVDPVITSI) MHC Pentamer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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