Anti-Human MET Recombinant Antibody (TAB-521CL)
CAT#: TAB-521CL
Recombinant Humanized monoclonal antibody expressed in CHO binding to Human MET. This antibody is an anti-c-Met antibody with significant preclinical single-agent activity against MA human xenograft tumors. This antibody was well tolerated and appeared to have substantial single-agent activity. In this small cohort of gastric patients MA appears to be more common in treatment-refractory tumors than in primary untreated tumors, suggesting that screening efforts should focus on this treatment-refractory patient population.
Tested Data
Gene Expression
ELISA
Figure 1 Anti-Human MET Recombinant Antibody (TAB-521CL) in ELISA
ELISA analysis of TAB-521CL was performed by coating with Recombinant Human MET Protein.
WB
Figure 2 Anti-Human MET Recombinant Antibody (TAB-521CL) in WB
Western blot analysis of TAB-521CL was performed with Recombinant Human MET Protein
Lane 1: Non-Reducing Antigen (0.5μg)
Lane 2: Reducing Antigen (0.5μg)
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Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55607/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/if_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18577/if_selected.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105976-MET
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Specifications
- Derivation
- Humanized
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- WB, FuncS
- Related Disease
- Cancer; Solid Tumors
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions
- Storage
- Store at -20°C for long-term storage. Store at 4°C for up to one month. Avoid freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay and Western Blot. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyr
- Gene ID
- 4233
- UniProt ID
- A0A024R759
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-521CL, RRID: AB_3111967)
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "MET"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G049E | Anti-MET immunotoxin (Fab)-PE | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-155 | Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (PABZ-155) | ELISA, Neut | ADCC enhanced antibody |
| AFC-TAB-H24 | Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H24) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-534LC | Mouse Anti-MET Recombinant Antibody (TAB-534LC) | FC, FuncS, Inhib | Mouse IgG |
| TAB-535LC | Mouse Anti-MET Recombinant Antibody (TAB-535LC) | FC, FuncS, Inhib | Mouse IgG |
| TAB-001MZ | Anti-Human MET Recombinant Antibody (DN30) | IHC, PET imaging | |
| TAB-011MZ | Mouse Anti-MET Recombinant Antibody (TAB-011MZ) | ELISA, WB, FC | Mouse IgG |
| MOB-0349MC | Recombinant Mouse Anti-Human c-Met antibody | WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-536LC | Human Anti-MET Recombinant Antibody (TAB-536LC) | Inhib | Human IgG2 |
| TAB-537LC | Human Anti-MET Recombinant Antibody (TAB-537LC) | Inhib | Human IgG2 |
| TAB-538LC | Human Anti-MET Recombinant Antibody (TAB-538LC) | Inhib | Human IgG2 |
| TAB-539LC | Human Anti-MET Recombinant Antibody (TAB-539LC) | Inhib | Human IgG2 |
| TAB-540LC | Human Anti-MET Recombinant Antibody (TAB-540LC) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-002MZ | Anti-Human MET Recombinant Antibody (TAB-002MZ) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-002MZ-S(P) | Anti-Human MET Recombinant Antibody scFv Fragment (TAB-002MZ-S(P)) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-002MZ-F(E) | Anti-Human MET Recombinant Antibody Fab Fragment (TAB-002MZ-F(E)) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-0880CLV | Human Anti-MET Recombinant Antibody (TAB-0880CLV) | ELISA, FuncS | Chimeric (mouse/human) IgG1 |
| TAB-0880CLV-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-0880CLV-S(P)) | ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-026MZ | Anti-Human MET Recombinant Antibody (73R009) | WB | Humanized antibody |
| TAB-0881CLV | Human Anti-MET Recombinant Antibody (TAB-0881CLV) | ELISA, FuncS | Humanized IgG1 |
| TAB-0883CLV | Human Anti-MET Recombinant Antibody (TAB-0883CLV) | ELISA, FuncS | Humanized IgG1 |
| TAB-0884CLV | Human Anti-MET Recombinant Antibody (TAB-0884CLV) | ELISA, FuncS | Humanized IgG1 |
| TAB-0885CLV | Human Anti-MET Recombinant Antibody (TAB-0885CLV) | ELISA, FuncS | Humanized IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1726CQ | Recombinant Rabbit Anti-MET Antibody (CBL1008) | Neut | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2216 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (DS2216AB) | ICC, IF, IHC-P, WB | IgG |
| MOR-4519 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH27DS) | WB, IF, ICC | IgG |
| MOR-4645 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH158DS) | WB, IF, ICC, FC, ELISA | IgG |
| MOR-4694 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH208DS) | WB, ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0071-YC | Mouse Anti-MET Recombinant Antibody (HPAB-0071-YC) | ELISA, Inhib | Mouse IgG |
| HPAB-0072-YC | Human Anti-MET Recombinant Antibody (HPAB-0072-YC) | ELISA | Humanized IgG1, κ |
| HPAB-0073-YC | Human Anti-MET Recombinant Antibody (HPAB-0073-YC) | ELISA | Human IgG1, κ |
| HPAB-0077-YC | Mouse Anti-MET Recombinant Antibody (clone LMH 89) | ELISA, FC, Stim, FuncS | Mouse IgG |
| HPAB-1298LY | Human Anti-MET Recombinant Antibody (HPAB-1298LY) | ELISA, IP | Human IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0123-FY-S(P) | Camelid Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0123-FY-S(P)) | ELISA | Camelid scFv |
| HPAB-1298LY-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1298LY-S(P)) | ELISA, IP | Human scFv |
| HPAB-1299LY-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1299LY-S(P)) | ELISA, IP | Human scFv |
| HPAB-1300LY-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1300LY-S(P)) | ELISA, IP | Human scFv |
| HPAB-1301LY-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1301LY-S(P)) | ELISA, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1298LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1298LY-F(E)) | ELISA, IP | Human Fab |
| HPAB-1299LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1299LY-F(E)) | ELISA, IP | Human Fab |
| HPAB-1300LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1300LY-F(E)) | ELISA, IP | Human Fab |
| HPAB-1301LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1301LY-F(E)) | ELISA, IP | Human Fab |
| HPAB-1302LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1302LY-F(E)) | ELISA, IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF474 | A*02:01/Human Hepatocyte growth factor receptor (YVDPVITSI) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY131 | Mouse Anti-NHP MET Recombinant Antibody (clone K.845.5) | WB, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY58 | Human Anti-Met (clone 5D5) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1336 | Anti-MET Immunohistochemistry Kit | IHC | |
| VS-0525-XY4357 | Anti-Mouse MET Immunohistochemistry Kit | IHC | |
| VS-0525-XY4356 | Anti-Human MET Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC479 | Recombinant Anti-MET Vesicular Antibody, EV Displayed (VS-0425-YC479) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC10 | Recombinant Anti-MET Biparatopic Antibody, Asymmetric hetero HC-LC | ELISA | Asymmetric hetero HC, common LC |
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