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Human Anti-MET Recombinant Antibody (clone 5D5); scFv Fragment (CAT#: PSBL-271)

Recombinant Human Antibody (5D5) is capable of binding to MET, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-MET scFv and CH1-3 region of human scFv and a light chain (LC) encoding VL from anti-MET scFv and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody potently inhibits HGF binding and receptor phosphorylation and signaling and has antibody-like pharmacokinetics and antitumor activity.


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  • Gene Expression
  • Datasheet
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Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55607/if_selected.jpg
Figure 2 IF staining of human cell line A-431
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/if_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18577/if_selected.jpg
Normal Tissue
Figure 4 Kidney
Figure 4 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_7_5.jpg
Figure 5 Testis
Figure 5 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)
Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105976-MET

Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • Human scFv
  • Specificity
  • Human MET
  • Species Reactivity
  • Human
  • Clone
  • 5D5
  • Applications
  • WB, Block, FuncS

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • MET; MET proto-oncogene; receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 5D5"

See other products for "MET"

Humanized Antibody

CAT Product Name Application Type
TAB-190-F(E) Anti-Human Met(Onartuzumab) IP, IF, FuncS, FC, Neut, ELISA, ICC Fab / Fc - G1 - kappa
TAB-521CL Anti-Human MET Recombinant Antibody (ABT-700) WB, FuncS Antibody
TAB-0332CL Human Anti-MET Recombinant Antibody (TAB-0332CL) ELISA Humanized Antibody
TAB-0332CL-S(P) Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0332CL-S(P)) ELISA Humanized scFv
TAB-026MZ Anti-Human MET Recombinant Antibody (73R009) WB Humanized antibody

Immunotoxin

CAT Product Name Application Type
AGTO-G049E Anti-MET immunotoxin (Fab)-PE Cytotoxicity assay, Function study

Recombinant Antibody

CAT Product Name Application Type
PABL-271 Human Anti-MET Recombinant Antibody (clone 5D5) WB, Block, FuncS Human IgG
HPAB-0760-CN Mouse Anti-MET Recombinant Antibody (HPAB-0760-CN) WB, ELISA, IHC, IP Mouse IgG
HPAB-0761-CN Human Anti-MET Recombinant Antibody (HPAB-0761-CN) WB, ELISA, IHC, IP Chimeric (mouse/human) IgG1, κ
HPAB-0762-CN Human Anti-MET Recombinant Antibody (HPAB-0762-CN) WB, ELISA, IHC, IP Humanized IgG1, κ
HPAB-0030-WJ Human Anti-MET Recombinant Antibody (HPAB-0030-WJ) ELISA, WB Human IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
PABZ-155 Afuco™ Anti-MET ADCC Recombinant Antibody (Onartuzumab), ADCC Enhanced ELISA, Neut ADCC enhanced antibody
AFC-TAB-H24 Afuco™ Anti-MET ADCC Recombinant Antibody (Emibetuzumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-002MZ Anti-Human MET Recombinant Antibody (MvDN30) IHC, PET imaging Chimeric antibody (mouse/human)
TAB-002MZ-S(P) Anti-Human MET Recombinant Antibody scFv Fragment (MvDN30) IHC, PET imaging Chimeric antibody (mouse/human)
TAB-002MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (MvDN30) IHC, PET imaging Chimeric antibody (mouse/human)
TAB-0880CLV-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0880CLV-F(E)) ELISA, FuncS Chimeric (mouse/human) Fab
TAB-0880CLV-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-0880CLV-S(P)) ELISA, FuncS Mouse scFv

Mouse Antibody

CAT Product Name Application Type
TAB-011MZ Mouse Anti-MET Recombinant Antibody (TAB-011MZ) ELISA, WB, FC Mouse IgG
TAB-012MZ Mouse Anti-MET Recombinant Antibody (TAB-012MZ) ELISA, WB, FC Mouse IgG
TAB-027MZ Mouse Anti-MET Recombinant Antibody (TAB-027MZ) WB, IP, IF Mouse lgG1
TAB-028MZ Mouse Anti-MET Recombinant Antibody (TAB-028MZ) IP Mouse lgG1
TAB-029MZ Mouse Anti-MET Recombinant Antibody (TAB-029MZ) IP, WB Mouse lgG1

Human Antibody

CAT Product Name Application Type
TAB-034MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (PGIA-1-A1) WB, ELISA Human antibody
TAB-035MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (PGIA-3-A9) WB, ELISA Human antibody
TAB-036MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (PGIA-3-A11) WB, ELISA Human antibody
TAB-037MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (PGIA-3-B2) WB, ELISA Human antibody
TAB-038MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (PGIA-4-A5) WB, ELISA Human antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1726CQ Recombinant Rabbit Anti-MET Antibody (CBL1008) Neut IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2216 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (DS2216AB) ICC/IF, IHC-P, WB IgG
MOR-4519 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH27DS) WB, IF, ICC IgG
MOR-4645 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH158DS) WB, IF, ICC, FC, ELISA IgG
MOR-4694 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH208DS) WB, ELISA IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-1298LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1298LY-F(E)) ELISA, IP Human Fab
HPAB-1299LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1299LY-F(E)) ELISA, IP Human Fab
HPAB-1300LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1300LY-F(E)) ELISA, IP Human Fab
HPAB-1301LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1301LY-F(E)) ELISA, IP Human Fab
HPAB-1302LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1302LY-F(E)) ELISA, IP Human Fab

scFv Fragment Antibody

CAT Product Name Application Type
PSBC-457 Human Anti-MET Recombinant Antibody (clone 107_A07); scFv Fragment ELISA, Block Human scFv
HPAB-M0153-YC-S(P) Mouse Anti-MET Recombinant Antibody (clone 3E1D7); scFv Fragment ELISA Mouse scFv
HPAB-0714-FY-F(E) Mouse Anti-MET Recombinant Antibody (clone AB013); scFv Fragment ELISA Mouse scFv
HPAB-0394-YJ-S(P) Human Anti-MET Recombinant Antibody (clone S1); scFv Fragment ELISA, WB, IP, FC Human scFv
HPAB-1579-FY-F(E) Human Anti-MET Recombinant Antibody (clone MET021); scFv Fragment WB, ELISA Human scFv

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-YF474 A*02:01/Human Hepatocyte growth factor receptor (YVDPVITSI) MHC Pentamer FCM

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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