Anti-MHC class II molecules Immunocytokine, IgG (chLym-1)-IL2 (ACFP-SH025)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-MHC class II molecules IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the MHC class II molecules as well as the biological activity of IL2. This antibody-cytokine fusion protein has demonstrated significant antitumor activity as direct therapeutics or as adjuvants of cancer vaccines. This immunocytokine was designed for treating B-cell NHL and chronic lymphocytic leukemia.
Specifications
- Target
- MHC class II molecules
- Molecule Class
- IgG1-IL2
- Species Reactivity
- Human
- Host
- Chimeric (Human-Mouse)
- Expression Host
- CHO
- Clone
- chLym-1
- Related Disease
- B-cell NHL and chronic lymphocytic leukemia
- Cytokines 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- DPB1; HLA DP1B; HLA-DPB1; Major histocompatibility complex class II DP beta 1; MHC class II antigen; MHC DPB1; MHC class II; I-Ek
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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