Anti-Human MSTN Recombinant Antibody (10B3C) (CAT#: TAB-456MZ)

Figure 1 shows inhibition of myostatin binding to ActRIIb by 10B3 and 10B3 chimera.

Figure 2 shows the 10B3 and 10B3 chimera inhibition of myostatin-induced activation of cell signalling, resulting in decreased luciferase expression in A204 cells.

Figure 3 shows the in vivo effects of 10B3 on body weight.

Figure 4 shows the ex vivo effects of 10B3 on muscle contractility in EDL, shows tetanic force.

Figure 5 shows 10B3, 10B3C, HOLO and H2L2 inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.

Figure 6 shows the effect of 10B3 and control antibody treatment on body weight in C-26 tumour bearing mice from day 0 to day 25.

Figure 7 shows the effect of 10B3 and control antibody treatment in sham operated and tenotomy surgery on mouse tibialis anterior (TA) muscle.