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    Anti-Human MSTN Recombinant Antibody (10B3C) (CAT#: TAB-456MZ)

    This antibody which binds to myostatin can be potentially used in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function. The chimeric antibody was constructed by taking variable regions from the 10B3 murine monoclonal antibody and grafting these on to human IgGl/k wild type constant regions.

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    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
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    We require custom production
    • Published Data
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Inhib

    Figure 1 shows inhibition of myostatin binding to ActRIIb by 10B3 and 10B3 chimera.

    Figure 1 shows inhibition of myostatin binding to ActRIIb by 10B3 and 10B3 chimera.

    Inhib

    Figure 2 shows the 10B3 and 10B3 chimera inhibition of myostatin-induced activation of cell signalling, resulting in decreased luciferase expression in A204 cells.

    Figure 2 shows the 10B3 and 10B3 chimera inhibition of myostatin-induced activation of cell signalling, resulting in decreased luciferase expression in A204 cells.

    FuncS

    Figure 3 shows the in vivo effects of 10B3 on body weight.

    Figure 3 shows the in vivo effects of 10B3 on body weight.

    FuncS

    Figure 4 shows the ex vivo effects of 10B3 on muscle contractility in EDL, shows tetanic force.

    Figure 4 shows the ex vivo effects of 10B3 on muscle contractility in EDL, shows tetanic force.

    FuncS

    Figure 5 shows 10B3, 10B3C, HOLO and H2L2 inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.

    Figure 5 shows 10B3, 10B3C, HOLO and H2L2 inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.

    FuncS

    Figure 6 shows the effect of 10B3 and control antibody treatment on body weight in C-26 tumour bearing mice from day 0 to day 25.

    Figure 6 shows the effect of 10B3 and control antibody treatment on body weight in C-26 tumour bearing mice from day 0 to day 25.

    FuncS

    Figure 7 shows the effect of 10B3 and control antibody treatment in sham operated and tenotomy surgery on mouse tibialis anterior (TA) muscle.

    Figure 7 shows the effect of 10B3 and control antibody treatment in sham operated and tenotomy surgery on mouse tibialis anterior (TA) muscle.


    Specifications

    • Host Species
    • Human
    • Type
    • Chimeric antibody (mouse/human)
    • Specificity
    • Human
    • Clone
    • 10B3C (or HCLC)
    • Applications
    • FuncS, Inhib
    • Related Disease
    • Muscle atrophy

    Applications

    • Application Notes
    • This antibody has been reported for use in Functional Assay, Inhibition.

    Target

    • Alternative Names
    • MSTN; myostatin; GDF8; MSLHP; growth/differentiation factor 8; GDF-8; growth differentiation factor 8

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone 10B3C (or HCLC)"

    See other products for "MSTN"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    Mouse Antibodies Humanized Antibodies Human Antibodies Chimeric Antibodies ScFv Antibodies IgG Antibodies Fab Antibodies Antibody Magnetic Beads ScFv-Fc Chimeras IHC Kits & Antibodies
    CAT Product Name Application Type
    TAB-0476CL Mouse Anti-MSTN Recombinant Antibody (TAB-0476CL) ELISA, WB Mouse IgG
    TAB-0477CL Mouse Anti-MSTN Recombinant Antibody (TAB-0477CL) ELISA, WB Mouse IgG
    TAB-0478CL Mouse Anti-MSTN Recombinant Antibody (TAB-0478CL) ELISA, WB Mouse IgG
    TAB-0479CL Mouse Anti-MSTN Recombinant Antibody (TAB-0479CL) ELISA, WB Mouse IgG
    TAB-0480CL Mouse Anti-MSTN Recombinant Antibody (TAB-0480CL) ELISA, WB Mouse IgG

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