Anti-Human MSTN Recombinant Antibody (10B3C)

Name: Anti-Human MSTN Recombinant Antibody (10B3C)
SKU: TAB-456MZ
Rating: 5 (1 reviews)

CAT#: TAB-456MZ

This antibody which binds to myostatin can be potentially used in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function. The chimeric antibody was constructed by taking variable regions from the 10B3 murine monoclonal antibody and grafting these on to human IgGl/k wild type constant regions.

Published Data Gene Expression

Inhib

Figure 1 shows inhibition of myostatin binding to ActRIIb by 10B3 and 10B3 chimera.

Inhib

Figure 2 shows the 10B3 and 10B3 chimera inhibition of myostatin-induced activation of cell signalling, resulting in decreased luciferase expression in A204 cells.

FuncS

Figure 3 shows the in vivo effects of 10B3 on body weight.

FuncS

Figure 4 shows the ex vivo effects of 10B3 on muscle contractility in EDL, shows tetanic force.

FuncS

Figure 5 shows 10B3, 10B3C, HOLO and H2L2 inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.

FuncS

Figure 6 shows the effect of 10B3 and control antibody treatment on body weight in C-26 tumour bearing mice from day 0 to day 25.

FuncS

Figure 7 shows the effect of 10B3 and control antibody treatment in sham operated and tenotomy surgery on mouse tibialis anterior (TA) muscle.

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Normal Tissue Figure 1 IHC staining of human skeletal muscle

Immunohistochemical staining of human skeletal muscle shows strong plasma positivity.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9963/166785_B_1_6_selected.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (LHCN-M2, RH-30)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138379-MSTN

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Specifications

Host Species
Human

Type
Chimeric antibody (mouse/human)

Specificity
Human

Clone
10B3C (or HCLC)

Applications
FuncS, Inhib

Related Disease
Muscle atrophy

Applications

Application Notes
This antibody has been reported for use in Functional Assay, Inhibition.

Target

Alternative Names
MSTN; myostatin; GDF8; MSLHP; growth/differentiation factor 8; GDF-8; growth differentiation factor 8

Gene ID
2660

UniProt ID
O14793

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-456MZ.pdf

MSDS

MSDS - TAB-456MZ.pdf

COA

Certificate of Analysis Lookup

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CAT	Product Name	Application	Type
TAB-456MZ-S(P)	Anti-Human MSTN Recombinant Antibody scFv Fragment (10B3C)	ELISA	Chimeric antibody (mouse/human)
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