Anti-Human MSTN Recombinant Antibody (H2L2) (CAT#: TAB-459MZ)
This antibody which binds to myostatin can be potentially used in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.
Specific Inquiry
FuncS
Figrue 1 shows binding of the H2L2-N54Q-C91S humanised anti-myostatin antibody variant to myostatin following treatment of the antibody with or without ammonium bicarbonate which can induce deamidation of the antibody.
FuncS
Figure 2 shows binding of the H2L2-C91S humanised anti-myostatin antibody variant to myostatin following treatment of the antibody with or without ammonium bicarbonate which can induce deamidation of the antibody.
Inhib
Figure 3 shows the H2L2-N54Q, H2L2-C91S, H2L2-N54Q-C91S humanised anti-myostatin antibody variants, H0L0, H2L2 and 10B3C inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.
ELISA
Figure 4 shows the binding of purified H2L2-N54Q, H2L2-C91S, H2L2- N54Q-C91S humanised anti-myostatin antibody variants, H2L2, HOLO and 10B3C (HCLC) to myostatin by ELISA.
Inhib
Figure 5 shows 10B3, 10B3C, HOLO and H2L2 inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.
Specifications
- Host Species
- Human
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- H2L2
- Applications
- ELISA, FuncS, Inhib
- Related Disease
- Muscle atrophy
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Functional Assay, Inhibition.
Target
- Alternative Names
- MSTN; myostatin; GDF8; MSLHP; growth/differentiation factor 8; GDF-8; growth differentiation factor 8
- Gene ID
- 2660
- UniProt ID
- O14793
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2313z | Mouse Anti-MSTN Recombinant Antibody (clone 19F12) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2b |
| HPAB-0025-FY | Human Anti-MSTN Recombinant Antibody (HPAB-0025-FY) | FC, SPR, FuncS | Human IgG |
| HPAB-0026-FY | Human Anti-MSTN Recombinant Antibody (HPAB-0026-FY) | FuncS | Human IgG |
| HPAB-M0165-YC | Mouse Anti-MSTN Recombinant Antibody (HPAB-M0165-YC) | Inhib, FuncS | Mouse IgG |
| HPAB-0058-YJ | Mouse Anti-MSTN Recombinant Antibody (HPAB-0058-YJ) | ELISA, Neut, IP | Mouse IgG |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0476CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0476CL) | ELISA, WB | Mouse IgG |
| TAB-0477CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0477CL) | ELISA, WB | Mouse IgG |
| TAB-0478CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0478CL) | ELISA, WB | Mouse IgG |
| TAB-0479CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0479CL) | ELISA, WB | Mouse IgG |
| TAB-0480CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0480CL) | ELISA, WB | Mouse IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-451MZ | Human Anti-MSTN Recombinant Antibody (TAB-451MZ) | FuncS, Inhib | Humanized IgG4 |
| TAB-457MZ | Anti-Human MSTN Recombinant Antibody (H0L0) | ELISA, FuncS, Inhib | Humanized antibody |
| TAB-458MZ | Anti-Human MSTN Recombinant Antibody (H1L2) | ELISA | Humanized antibody |
| TAB-451MZ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-451MZ-S(P)) | ELISA | Humanized scFv |
| TAB-457MZ-S(P) | Anti-Human MSTN Recombinant Antibody scFv Fragment (H0L0) | ELISA | Humanized antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-456MZ | Anti-Human MSTN Recombinant Antibody (10B3C) | FuncS, Inhib | Chimeric antibody (mouse/human) |
| TAB-456MZ-S(P) | Anti-Human MSTN Recombinant Antibody scFv Fragment (10B3C) | ELISA | Chimeric antibody (mouse/human) |
| TAB-456MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (10B3C) | ELISA | Chimeric antibody (mouse/human) |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-452MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-452MZ-F(E)) | ELISA | Human Fab |
| TAB-453MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-453MZ-F(E)) | ELISA | Human Fab |
| TAB-454MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (F1-10) | SDS-PAGE, WB, ELISA | Human antibody |
| TAB-460MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-460MZ-F(E)) | ELISA | Human Fab |
| TAB-461MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-461MZ-F(E)) | ELISA | Human Fab |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0268CQ-F(E) | Mouse Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0268CQ-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-0269CQ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0269CQ-F(E)) | ELISA, Neut | Human Fab |
| HPAB-0270CQ-F(E) | Mouse Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0270CQ-F(E)) | ELISA, FC, DB, Block | Mouse Fab |
| HPAB-0271CQ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0271CQ-F(E)) | ELISA, FC, DB, Block | Human Fab |
| HPAB-0056-WJ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0056-WJ-F(E)) | ELISA, WB | Humanized Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0165-YC-S(P) | Mouse Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-M0165-YC-S(P)) | ELISA, Block, FuncS | Mouse scFv |
| HPAB-0659-WJ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0659-WJ-S(P)) | WB | Human scFv |
| HPAB-3144LY-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-3144LY-S(P)) | ELISA, FC | Human scFv |
| HPAB-3145LY-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-3145LY-S(P)) | ELISA, FC | Human scFv |
| HPAB-0580YY-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0580YY-S(P)) | ELISA, FuncS | Humanized scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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