Recombinant Mouse Anti-MUC1 Antibody scFv Fragment (CTM01) (CAT#: PABX-183-S (P))
Anti-MUC1 antibody is a Mouse of scFv class that binds to an MUC1.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
-1.png)
Figure 1 In Vitro Cytotoxicity of CTM01 Carbohydrate and Amide Conjugates
Hamann, P. R., Hinman, L. M., Beyer, C. F., Greenberger, L. M., Lin, C., Lindh, D., ... & Upeslacis, J. (2005). An anti-MUC1 antibody− calicheamicin conjugate for treatment of solid tumors. Choice of linker and overcoming drug resistance. Bioconjugate chemistry, 16(2), 346-353.
-2.png)
Figure 2 Time-course of the response of Lu-78 xenograft tumors to the CTM01 amide conjugate, to a similar control conjugate made with the nonbinding MOPC-21 antibody, and to treatment with a representative calicheamicin derivative alone.
Athymic mice were implanted sc with Lu-78 cells and then dosed when tumors were approximately 50 mg in size. The doses indicated were given on days 14, 18, and 22, as indicated by the arrows, and are given in calicheamicin equivalents. The corresponding concentration of antibody is 40-fold greater. There were no deaths in any group, except for one with NAc-gamma calicheamicin. Error bars are SEMs and were omitted for NAc-gamma calicheamicin (dosed at the MTD) for clarity.
Hamann, P. R., Hinman, L. M., Beyer, C. F., Greenberger, L. M., Lin, C., Lindh, D., ... & Upeslacis, J. (2005). An anti-MUC1 antibody− calicheamicin conjugate for treatment of solid tumors. Choice of linker and overcoming drug resistance. Bioconjugate chemistry, 16(2), 346-353.
-3.png)
Figure 3 Competitive radioimmunoassay for mCTM01 and hCTM01.
Affinity of the humanized antibody relative to the murine antibody is 1.3.
Hamann, P. R., Hinman, L. M., Beyer, C. F., Lindh, D., Upeslacis, J., Shochat, D., & Mountain, A. (2005). A Calicheamicin Conjugate with a Fully Humanized Anti-MUC1 Antibody Shows Potent Antitumor Effects in Breast and Ovarian Tumor Xenografts. Bioconjugate Chemistry, 16(2), 354–360.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- scFv
- Specificity
- Tested positive against native Streptomyces lividans KCSA
- Species Reactivity
- Human
- Clone
- CTM01
- Applications
- Neut Assay-Dependent
FuncS Assay-Dependent
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The antibody scFv Fragment CTM01 has been reported in applications of Neut, FuncS. It's recommended that the optimal antibody concentration, dilution, incubition time etc. are best to be carefully titrated in specific assays.
Target
- Alternative Names
- MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; Medullary cystic kidney disease, autosomal dominant;
- Gene ID
- 4582
- UniProt ID
- P15941
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone CTM01"
See other products for "MUC1"
Select a product category from the dropdown menu below to view related products.
Please select product type
Single Domain Antibody Products
Immunotoxin Products
IgG Antibody Products
Fab Antibody Products
ScFv Antibody Products
Human Antibody Products
Mouse Antibody Products
Chimeric Antibody Products
Humanized Antibody Products
Fab Glycosylation Antibody Products
Sialylated IgG Glycan Products
Fc Glycosylation Antibody Products
Deglycosylated Antibody Products
Chicken IgY Antibody Products
MHC Tetramer Products for Cancer
Rabbit Monoclonal Antibody Products
Epitope-Specific Antibody Products
ADCC Enhanced Antibody Products
IgM Antibody Products
Antibody Magnetic Beads
ScFv-Fc Chimera Products
Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2049-VHH | Recombinant Anti-human MUC1 VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
| HPAB-AP504-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP504-YC) | FC | Camel VHH |
| HPAB-AP505-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP505-YC) | ELISA | Camel VHH |
| HPAB-0736-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0736-YJ-VHH) | ELISA | Camelid VHH |
| HPAB-0737-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0737-YJ-VHH) | ELISA | Camelid VHH |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for PABX-183-S (P). Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
-2.png)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, FC, FuncS
For Research Use Only. Not For Clinical Use.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
