Recombinant Mouse Anti-MUC1 Antibody scFv Fragment (CTM01) (CAT#: PABX-183-S (P))
Anti-MUC1 antibody is a Mouse of scFv class that binds to an MUC1.
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Figure 1 In Vitro Cytotoxicity of CTM01 Carbohydrate and Amide Conjugates
Hamann, P. R., Hinman, L. M., Beyer, C. F., Greenberger, L. M., Lin, C., Lindh, D., ... & Upeslacis, J. (2005). An anti-MUC1 antibody− calicheamicin conjugate for treatment of solid tumors. Choice of linker and overcoming drug resistance. Bioconjugate chemistry, 16(2), 346-353.
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Figure 2 Time-course of the response of Lu-78 xenograft tumors to the CTM01 amide conjugate, to a similar control conjugate made with the nonbinding MOPC-21 antibody, and to treatment with a representative calicheamicin derivative alone.
Athymic mice were implanted sc with Lu-78 cells and then dosed when tumors were approximately 50 mg in size. The doses indicated were given on days 14, 18, and 22, as indicated by the arrows, and are given in calicheamicin equivalents. The corresponding concentration of antibody is 40-fold greater. There were no deaths in any group, except for one with NAc-gamma calicheamicin. Error bars are SEMs and were omitted for NAc-gamma calicheamicin (dosed at the MTD) for clarity.
Hamann, P. R., Hinman, L. M., Beyer, C. F., Greenberger, L. M., Lin, C., Lindh, D., ... & Upeslacis, J. (2005). An anti-MUC1 antibody− calicheamicin conjugate for treatment of solid tumors. Choice of linker and overcoming drug resistance. Bioconjugate chemistry, 16(2), 346-353.
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Figure 3 Competitive radioimmunoassay for mCTM01 and hCTM01.
Affinity of the humanized antibody relative to the murine antibody is 1.3.
Hamann, P. R., Hinman, L. M., Beyer, C. F., Lindh, D., Upeslacis, J., Shochat, D., & Mountain, A. (2005). A Calicheamicin Conjugate with a Fully Humanized Anti-MUC1 Antibody Shows Potent Antitumor Effects in Breast and Ovarian Tumor Xenografts. Bioconjugate Chemistry, 16(2), 354–360.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- scFv
- Specificity
- Tested positive against native Streptomyces lividans KCSA
- Species Reactivity
- Human
- Clone
- CTM01
- Applications
- Neut Assay-Dependent
FuncS Assay-Dependent
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The antibody scFv Fragment CTM01 has been reported in applications of Neut, FuncS. It's recommended that the optimal antibody concentration, dilution, incubition time etc. are best to be carefully titrated in specific assays.
Target
- Alternative Names
- MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; Medullary cystic kidney disease, autosomal dominant;
- Gene ID
- 4582
- UniProt ID
- P15941
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2049-VHH | Recombinant Anti-human MUC1 VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
| HPAB-AP504-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP504-YC) | FC | Camel VHH |
| HPAB-AP505-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP505-YC) | ELISA | Camel VHH |
| HPAB-0736-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0736-YJ-VHH) | ELISA | Camelid VHH |
| HPAB-0737-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0737-YJ-VHH) | ELISA | Camelid VHH |
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