Anti-Human MUC1 Recombinant Antibody (PH1) (CAT#: TAB-431MZ)
This human antibody can recognize the tumor-associated MUC1. It is useful for tumor-targeting applications including radioimmunotherapy, radioimmunoscintigraphy, conjugation to cytotoxic reagents, and immune cell stimulation.
Specific Inquiry
SPR
Figure 1 BIAcore analysis of PH1-Fab.
Binding pattern of PH1 (A) and its analysis at steady state [response units equilibrium (RUeq)]).
Henderikx, P., Coolen-van Neer, N., Jacobs, A., van der Linden, E., Arends, J. W., Müllberg, J., & Hoogenboom, H. R. (2002). A human immunoglobulin G1 antibody originating from an in vitro-selected Fab phage antibody binds avidly to tumor-associated MUC1 and is efficiently internalized. The American journal of pathology, 160(5), 1597-1608.
SPR
Figure 2 BIAcore analysis of PH1-IgG1.
Binding pattern of IgG1-PH1, fitted with the BIAevaluation program (version 3.01).
Henderikx, P., Coolen-van Neer, N., Jacobs, A., van der Linden, E., Arends, J. W., Müllberg, J., & Hoogenboom, H. R. (2002). A human immunoglobulin G1 antibody originating from an in vitro-selected Fab phage antibody binds avidly to tumor-associated MUC1 and is efficiently internalized. The American journal of pathology, 160(5), 1597-1608.
FC
Figure 3 Flow cytometry. Comparison between HMFG1 and PH1-IgG1 for their binding characteristics to tumor cell lines.
Thick line, binding with the antibody; thin line, nonspecific binding control; dotted line, inhibition with MUC1 60-mer.
Henderikx, P., Coolen-van Neer, N., Jacobs, A., van der Linden, E., Arends, J. W., Müllberg, J., & Hoogenboom, H. R. (2002). A human immunoglobulin G1 antibody originating from an in vitro-selected Fab phage antibody binds avidly to tumor-associated MUC1 and is efficiently internalized. The American journal of pathology, 160(5), 1597-1608.
IHC
Figure 4 Immunohistochemical staining with PH1-IgG1 of cancer and normal tissues.
P, Proximal tubuli; D, distal tubuli; LH, loop of Henle.
Henderikx, P., Coolen-van Neer, N., Jacobs, A., van der Linden, E., Arends, J. W., Müllberg, J., & Hoogenboom, H. R. (2002). A human immunoglobulin G1 antibody originating from an in vitro-selected Fab phage antibody binds avidly to tumor-associated MUC1 and is efficiently internalized. The American journal of pathology, 160(5), 1597-1608.
Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Clone
- PH1
- Applications
- ELISA, WB, FC, IHC, SPR
- Related Disease
- Lung, bladder, ovarian, prostate, and breast adenocarcinoma
Applications
- Application Notes
- The antibody was validated for ELISA, Immunohistochemistry, Western Blot, Flow Cytometry, Surface Plasmon Resonance. For details, refer to Published Data.
Target
- Alternative Names
- MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; Medullary cystic kidney disease, autosomal dominant;
- Gene ID
- 4582
- UniProt ID
- P15941
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2049-VHH | Recombinant Anti-human MUC1 VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
| HPAB-AP504-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP504-YC) | FC | Camel VHH |
| HPAB-AP505-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP505-YC) | ELISA | Camel VHH |
| HPAB-0736-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0736-YJ-VHH) | ELISA | Camelid VHH |
| HPAB-0737-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0737-YJ-VHH) | ELISA | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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