Anti-Human MUC1 Recombinant Antibody (PH1) (CAT#: TAB-431MZ)
This human antibody can recognize the tumor-associated MUC1. It is useful for tumor-targeting applications including radioimmunotherapy, radioimmunoscintigraphy, conjugation to cytotoxic reagents, and immune cell stimulation.
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SPR
Figure 1 BIAcore analysis of PH1-Fab.
Binding pattern of PH1 (A) and its analysis at steady state [response units equilibrium (RUeq)]).
Henderikx, P., Coolen-van Neer, N., Jacobs, A., van der Linden, E., Arends, J. W., Müllberg, J., & Hoogenboom, H. R. (2002). A human immunoglobulin G1 antibody originating from an in vitro-selected Fab phage antibody binds avidly to tumor-associated MUC1 and is efficiently internalized. The American journal of pathology, 160(5), 1597-1608.
SPR
Figure 2 BIAcore analysis of PH1-IgG1.
Binding pattern of IgG1-PH1, fitted with the BIAevaluation program (version 3.01).
Henderikx, P., Coolen-van Neer, N., Jacobs, A., van der Linden, E., Arends, J. W., Müllberg, J., & Hoogenboom, H. R. (2002). A human immunoglobulin G1 antibody originating from an in vitro-selected Fab phage antibody binds avidly to tumor-associated MUC1 and is efficiently internalized. The American journal of pathology, 160(5), 1597-1608.
FC
Figure 3 Flow cytometry. Comparison between HMFG1 and PH1-IgG1 for their binding characteristics to tumor cell lines.
Thick line, binding with the antibody; thin line, nonspecific binding control; dotted line, inhibition with MUC1 60-mer.
Henderikx, P., Coolen-van Neer, N., Jacobs, A., van der Linden, E., Arends, J. W., Müllberg, J., & Hoogenboom, H. R. (2002). A human immunoglobulin G1 antibody originating from an in vitro-selected Fab phage antibody binds avidly to tumor-associated MUC1 and is efficiently internalized. The American journal of pathology, 160(5), 1597-1608.
IHC
Figure 4 Immunohistochemical staining with PH1-IgG1 of cancer and normal tissues.
P, Proximal tubuli; D, distal tubuli; LH, loop of Henle.
Henderikx, P., Coolen-van Neer, N., Jacobs, A., van der Linden, E., Arends, J. W., Müllberg, J., & Hoogenboom, H. R. (2002). A human immunoglobulin G1 antibody originating from an in vitro-selected Fab phage antibody binds avidly to tumor-associated MUC1 and is efficiently internalized. The American journal of pathology, 160(5), 1597-1608.
Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Clone
- PH1
- Applications
- ELISA, WB, FC, IHC, SPR
- Related Disease
- Lung, bladder, ovarian, prostate, and breast adenocarcinoma
Applications
- Application Notes
- The antibody was validated for ELISA, Immunohistochemistry, Western Blot, Flow Cytometry, Surface Plasmon Resonance. For details, refer to Published Data.
Target
- Alternative Names
- MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; Medullary cystic kidney disease, autosomal dominant;
- Gene ID
- 4582
- UniProt ID
- P15941
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2049-VHH | Recombinant Anti-human MUC1 VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
| HPAB-AP504-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP504-YC) | FC | Camel VHH |
| HPAB-AP505-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP505-YC) | ELISA | Camel VHH |
| HPAB-0736-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0736-YJ-VHH) | ELISA | Camelid VHH |
| HPAB-0737-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0737-YJ-VHH) | ELISA | Camelid VHH |
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