Recombinant Human Anti-Merozoite surface protein 2 (MSP2) Antibody (h6D8) (CAT#: PABL-644)
Recombinant Human Antibody (h6D8) is capable of binding to Merozoite surface protein 2 (MSP2), expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-Merozoite surface protein 2 (MSP2) mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-Merozoite surface protein 2 (MSP2) proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. The recognition of a conserved N-terminal epitope by h6D8 is incompatible with the membrane-bound conformation of that region,
Specific Inquiry
WB
Figure 1 Western blotting on recombinant (lanes 1 and 2) and parasite (lanes 3 and 4) 3D7 (lanes 1 and 3) and FC27 (lanes 2 and 4) MSP2.
Analyses of the six MAbs that recognize epitopes in the conserved N-terminal (6D8) regions of MSP2 as well as control blots probed with polyclonal sheep anti-3D7 and anti-FC27 MSP2 antisera.
Adda, C. G., MacRaild, C. A., Reiling, L., Wycherley, K., Boyle, M. J., Kienzle, V., ... & Anders, R. F. (2012). Antigenic characterization of an intrinsically unstructured protein, Plasmodium falciparum merozoite surface protein 2. Infection and immunity, 80(12), 4177-4185.
WB
Figure 2 Western blots of parasite 3D7 MSP2 (lanes 1 and 3) and FC27 MSP2 (lanes 2 and 4) subjected to SDS-PAGE under reducing (lanes 1 and 2) and nonreducing (lanes 3 and 4) conditions.
The 6D8 epitope was enhanced by reduction of FC27 MSP2.
Adda, C. G., MacRaild, C. A., Reiling, L., Wycherley, K., Boyle, M. J., Kienzle, V., ... & Anders, R. F. (2012). Antigenic characterization of an intrinsically unstructured protein, Plasmodium falciparum merozoite surface protein 2. Infection and immunity, 80(12), 4177-4185.
Specifications
- Immunogen
- P. falciparum merozoite surface protein 2 precursor
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native Merozoite surface protein 2 (MSP2)
- Species Reactivity
- P. falciparum
- Clone
- h6D8
- Applications
- WB
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-659 | Recombinant Mouse Anti-MSP2 Antibody (6D8) | WB, IF, FuncS | IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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