This product is a human IgG1, κ antibody that can recognize human NECTIN4.
Figure 1 AGS-22M6 antibody specifically recognizes cell-surface human nectin-4 and its orthologs.
Cell counts of PC-3 cells expressing human, monkey, and rat nectin-4 (open histograms) were overlaid against mocktransfected PC-3 cells (solid histogram).
Figure 2 FC measures the binding of AGS-22M6 antibody to human nectin-4.
Saturation curve of AGS-22M6 and AGS-22M6E binding to nectin-4 expressed on T-47D by flow cytometry shows KD of 0.01 nmol/L. MFI, mean fluorescence intensity
Figure 3 AGS-22M6E ADC shows potent and specific in vitro cytotoxicity.
PC-3 cells engineered to express human were incubated with increasing concentrations of unconjugated AGS-22M6.
Figure 4 T-47D breast cancer cells were killed by AGS-22M6E ADC.
T-47D breast cancer cells, were incubated with increasing concentrations of unconjugated AGS-22M6.
Figure 5 Nectin-4–targeted ADC shows significant tumor growth inhibition in multiple xenograft models.
AG-B1 subcutaneous xenografts treated with AGS-22M6E (or controls) at 0.8 mg/kg.
Figure 6 AGS-22M6E ADC shows significant tumor growth inhibition in multiple xenograft models.
AG-Br7 orthotopic xenografts treated with AGS-22M6E (or controls) at 5 mg/kg.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
|HPAB-0034-DJB||Mouse Anti-NECTIN4 Recombinant Antibody (clone N41)||ELISA, IHC, FC||Mouse IgG|
|VS4-CJ51||Recombinant Human Anti-NECTIN4 Antibody (clone 6D3)||ELISA||Human IgG1|
|VS-0723-WK124||Human Anti-NECTIN4 Recombinant Antibody (VS-0723-WK124)||FC||Chimeric (rabbit/human) IgG1|
|HPAB-0034-DJB-S(P)||Mouse Anti-NECTIN4 Recombinant Antibody (clone N41); scFv Fragment||ELISA, IHC, FC||Mouse scFv|
|HPAB-0034-DJB-F(E)||Mouse Anti-NECTIN4 Recombinant Antibody (clone N41); Fab Fragment||ELISA, IHC, FC||Mouse Fab|
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.