Afuco™ Anti-Human NONO ADCC Recombinant Antibody (PAT-LM1), ADCC Enhanced (CAT#: AFC-660CL)
Anti-NONO ADCC Enhanced Antibody (PAT-LM1) is an ADCC enhanced antibody produced by our Afuco™ platform. PAT-LM1 bingding to non-POU domain-containing octamer-binding protein (NONO) is a natural human antibody that can be used as a potential treatment for multiple types of cancer, with a particularly strong potency against colon, lung, breast, ovary, pancreatic cancers, lympoma.
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MTT assay
Figure 4 show a series of graphs of the results of MTT reduction assays for mitochondrial dehydrogenase activity.
The LM-I monoclonal antibody inhibits cell proliferation and decreases survival, or induces apoptosis of EPLC-272H epidermoid cell carcinoma of the lung cells after A) 24 hours of incubation; and B) 48 hours of incubation.
FuncS
Figure 5 shows a graph showing that the LM-I antibody induces apoptosis.
A series of graphs of the results of a cell death ELISA showing that the LM-1 monoclonal antibody induces apoptosis of LOU-NH91 cells after A) 24 hours of incubation; and B) 48 hours of incubation.
Figure 6 The results of screening for antibody LM-I binding to oligosaccharides.
FuncS
Figure 7 shows body weight of LM-I injected mice, which was maintained for 8 weeks post injection.
Body weight in the no injection control and non-specific IgM injected control was reduced by almost 20%, due to poor health from liver metastasis.
Figure 8 shows data indicating that LM-I antibody can reduce tumor metastasis establishment, formation, or proliferation (growth).
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- WB, ELISA, FC, MTT assay
- Related Disease
- Colon Cancer; Lung Cancer; Breast Cancer; Ovary Cancer; Pancreatic Cancers; Lympoma
Product Property
- Purity
- >95% as judged by SDS-polyacrylamide gel electrophoresis
- Storage
- Store at -20°C. Open under aseptic conditions.
Applications
- Application Notes
- The antibody was validated for Western Blot, ELISA, Flow Cytometry, MTT assay. For details, refer to Published Data.
Target
- Alternative Names
- NONO; non-POU domain-containing octamer-binding protein
- Gene ID
- 4841
- UniProt ID
- Q15233
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "NONO"
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IgG Antibody Products
IgM Antibody Products
Human Antibody Products
Rabbit Monoclonal Antibody Products
ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3007z | Mouse Anti-NONO Recombinant Antibody (clone 24H3) | WB, IF, IHC | Mouse IgG1 |
| HPAB-0766-CN | Human Anti-NONO Recombinant Antibody (HPAB-0766-CN) | WB, ELISA, IHC, IP | Human IgG |
| MRO-1154-CN | Recombinant Rabbit Anti-NONO Monoclonal Antibody (JG87-38) | WB, IF, IHC | Rabbit IgG |
| ZG-0061U | Rabbit Anti-NONO Recombinant Antibody (clone 8C11) | ELISA, WB, IHC, IF | Rabbit IgG |
| VS3-FY1048 | Recombinant Rabbit Anti-NONO Antibody (clone R05-1F8) | WB, IHC-Fr, IHC-P, ICC, IF | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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