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  • Anti-Human NOTCH1 Recombinant Antibody Fab Fragment (A12.2)

Anti-Human NOTCH1 Recombinant Antibody Fab Fragment (A12.2) (CAT#: TAB-544MZ-F(E))

This antibody shows a neutralization activity and can inhibit Notch ligand-induced signaling with the ability to inhibit growth of HPB-ALL cells.

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  • Gene Expression
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Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Figure 1 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67168/1315_F7_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human pancreas
Figure 2 IHC staining of human pancreas
(Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22466/61564_A_3_3_selected.jpg
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_B_8_5.jpg
Figure 4 Colon
Figure 4 Colon
(Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes - Microvilli Staining: Medium Intensity: Moderate Fibroblasts Staining: High Intensity: Strong Mucosal lymphoid cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_3.jpg
Figure 5 Liver
Figure 5 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_4.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_5.jpg
Figure 7 Testis
Figure 7 Testis
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_6_6.jpg
Figure 8 Lymph node
Figure 8 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)
Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148400-NOTCH1

Specifications

  • Immunogen
  • Human Notch1
  • Host Species
  • Human
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Clone
  • A12.2
  • Applications
  • Enzyme-linked Immunosorbent Assay, Western blot, Luciferase reporter assay
  • Related Disease
  • T-cell acute lymphoblastic leukemia (T-ALL), breast cancer

Target

  • Alternative Names
  • NOTCH1; AOS5; AOVD1; TAN1; hN1

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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CAT Product Name Application Type
MOB-1747z Mouse Anti-NOTCH1 Recombinant Antibody (clone 21H9) WB, ICC, IF, IHC Mouse IgG2b
MOB-1438CT Recombinant Mouse anti-Mouse NOTCH1 Monoclonal antibody (3E12) FC
MRO-1102-CN Recombinant Rabbit Anti-NOTCH1 Monoclonal Antibody (CBACN-405) WB, IF, IHC, IP, FC Rabbit IgG
FN-101CQ Recombinant Armenian hamster Anti-NOTCH1 Antibody (HMN1-12) FC, IHC Armenian Hamster IgG
HPAB-0085-YJ Rat Anti-NOTCH1 Recombinant Antibody (HPAB-0085-YJ) IF, IHC, WB Rat IgG1, κ

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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