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    Anti-Human NOTCH1 Recombinant Antibody Fab Fragment (N1wc75) (CAT#: TAB-550MZ-F(E))

    This antibody can block Notchl/Fc and Notchl ligand interaction by binding to the cell surface receptor, Notch1 receptor. It can be potentially used for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of Notch1.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line HaCaT
    Figure 1 IF staining of human cell line HaCaT
    (Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/67168/1315_F7_4_selected.jpg
    Normal Tissue
    Figure 2 IHC staining of human pancreas
    Figure 2 IHC staining of human pancreas
    (Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/22466/61564_A_3_3_selected.jpg
    Figure 3 Cerebral cortex
    Figure 3 Cerebral cortex
    (Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_B_8_5.jpg
    Figure 4 Colon
    Figure 4 Colon
    (Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes - Microvilli Staining: Medium Intensity: Moderate Fibroblasts Staining: High Intensity: Strong Mucosal lymphoid cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_3.jpg
    Figure 5 Liver
    Figure 5 Liver
    (Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_4.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_6_6.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)
    Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148400-NOTCH1

    Specifications

    • Host Species
    • Human
    • Derivation
    • Phage display library
    • Type
    • Human antibody
    • Specificity
    • Human
    • Clone
    • N1wc75
    • Applications
    • Enzyme-linked Immunosorbent Assay, Western blot, Flow Cytometry
    • Related Disease
    • Pathological hyperproliferative oncogenic disorders

    Target

    • Alternative Names
    • NOTCH1; AOS5; AOVD1; TAN1; hN1

    Related Resources

    • Related Diseases

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    See other products for "NOTCH1"

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    ScFv Antibody Products Mouse Antibody Products Humanized Antibody Products Human Antibody Products IgG Antibody Products Blocking Antibody Products Rabbit Monoclonal Antibody Products Fab Antibody Products Neuroscience Antibody Products ADCC Enhanced Antibody Products Cancer Stem Cell Biomarker Specific Antibody Products Non-Human Primate (NHP) Antibody Products Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research ScFv-Fc Chimera Products IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry Extracellular Vesicle (EV) Antibody Products
    CAT Product Name Application Type
    PSBL-660 Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment ELISA Human scFv
    HPAB-AP750-YC-S(P) Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133); scFv Fragment ELISA, FC Human scFv
    HPAB-AP751-YC-S(P) Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc155); scFv Fragment ELISA, FC Human scFv
    HPAB-AP752-YC-S(P) Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc49); scFv Fragment ELISA, FC Human scFv
    HPAB-AP753-YC-S(P) Human Anti-NOTCH1 Recombinant Antibody (clone N1wc104); scFv Fragment ELISA, FC Human scFv

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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