Anti-Human NOTCH1 Recombinant Antibody (N1wc75) (CAT#: TAB-550MZ)

This antibody can block Notchl/Fc and Notchl ligand interaction by binding to the cell surface receptor, Notch1 receptor. It can be potentially used for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of Notch1.


Specific Inquiry
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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
ELISA

Figure 1 displays binding affinity determination (EC50) in ELISA using different concentrations of purified IgG protein.

Figure 1 displays binding affinity determination (EC50) in ELISA using different concentrations of purified IgG protein.

FC

Figue 2 shows the FACS analysis of Notch antibodies binding to (A) 293 FIpIn (TREx) cells stably expressing the different Notch paralogs.

Figue 2 shows the FACS analysis of Notch antibodies binding to (A) 293 FIpIn (TREx) cells stably expressing the different Notch paralogs.

FuncS

Figure 3 shows the effect of Notch mAbs on the Jag-2-induced luciferase reporter gene activity in U2OS FIpIn TREx cells stably expressing hNotch1.

Figure 3 shows the effect of Notch mAbs on the Jag-2-induced luciferase reporter gene activity in U2OS FIpIn TREx cells stably expressing hNotch1.


Specifications

  • Host Species
  • Human
  • Derivation
  • Phage display library
  • Type
  • Human antibody
  • Specificity
  • Human
  • Clone
  • N1wc75
  • Applications
  • ELISA, FC, FuncS
  • Related Disease
  • Pathological hyperproliferative oncogenic disorders

Applications

  • Application Notes
  • This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Flow Cytotoxicityometry, Functional Assay.

Target

  • Alternative Names
  • NOTCH1; AOS5; AOVD1; TAN1; hN1

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone N1wc75"

See other products for "NOTCH1"

Mouse Antibody

Humanized Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1786CQ Recombinant Mouse Anti-NOTCH1 Antibody (MHN1-519) FC, BL IgG1, κ

Rabbit Monoclonal Antibody

Neuroscience Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H11 Afuco™ Anti-NOTCH1 ADCC Recombinant Antibody (Brontictuzumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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