Anti-Human NOTCH1 Antibody, Research Grade Biosimilar
CAT#: TAB-688CL
Recombinant Human monoclonal antibody expressed in CHO binding to Human NOTCH1. Notch1-specific monoclonal antibody targets the Notch1 pathway in cancer. AVEO's Notch1 antibody uses as an anti-angiogenic agent to effectively inhibit tumor angiogenesis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67168/1315_F7_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22466/61564_A_3_3_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes - Microvilli Staining: Medium Intensity: Moderate Fibroblasts Staining: High Intensity: Strong Mucosal lymphoid cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148400-NOTCH1
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Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by analysis by RP-HPLC
- Storage
- Store at –20 or -70°C upon receipt. Divide antibody into aliquots prior usage and avoid multiple freeze-thaw cycles.
Target
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Related Diseases
Breast Cancer
Endocrine Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "NOTCH1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-666 | Human Anti-NOTCH1 Recombinant Antibody | ELISA | Human IgG |
| MOB-1438CT | Recombinant Mouse anti-Mouse NOTCH1 Monoclonal antibody (3E12) | FC | |
| HPAB-0078-YC | Mouse Anti-NOTCH1 Recombinant Antibody (clone OMP-52M51) | IHC | Mouse IgG |
| HPAB-0044LY | Mouse Anti-NOTCH1 Recombinant Antibody (HPAB-0044LY) | WB | Mouse IgG1 |
| ZG-0032U | Rabbit Anti-NOTCH1 Recombinant Antibody (clone 4F6) | ELISA, WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-660 | Human Anti-NOTCH1 Recombinant Antibody; Fab Fragment | ELISA | Human Fab |
| HPAB-0681-WJ-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone h52M51); Fab Fragment | ELISA, WB | Humanized Fab |
| HPAB-AP750-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-AP751-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc155); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-AP752-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc49); Fab Fragment | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-539MZ | Rat Anti-NOTCH1 Recombinant Antibody (TAB-539MZ) | WB, Competition ELISA, Neut | Rat IgG1 |
| TAB-543MZ | Anti-Human NOTCH1 Recombinant Antibody (mAb N248A) | ELISA, WB, Luciferase reporter assay | |
| TAB-539MZ-S(P) | Rat Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-539MZ-S(P)) | WB, Competition ELISA | Rat scFv |
| TAB-540MZ-S(P) | Rat Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-540MZ-S(P)) | WB, Competition ELISA | Rat scFv |
| TAB-543MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (mAb N248A) | ELISA, WB, Luciferase reporter assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-541MZ | Human Anti-NOTCH1 Recombinant Antibody (TAB-541MZ) | Neut, WB | Humanized antibody |
| TAB-542MZ | Human Anti-NOTCH1 Recombinant Antibody (TAB-542MZ) | Neut, WB | Humanized antibody |
| TAB-541MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-541MZ-S(P)) | WB, Competition ELISA | Humanized scFv |
| TAB-542MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-542MZ-S(P)) | WB, Competition ELISA | Humanized scFv |
| TAB-544MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (A12.2) | ELISA, WB, Luciferase reporter assay | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-545MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (23814) | ELISA | Human antibody |
| TAB-546MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (23418.8) | ELISA | Human antibody |
| TAB-547MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-547MZ-S(P)) | ELISA | Human scFv |
| TAB-548MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-548MZ-S(P)) | ELISA | Human scFv |
| TAB-549MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-549MZ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1786CQ | Recombinant Mouse Anti-NOTCH1 Antibody (MHN1-519) | FC, BL | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2473 | Hi-Affi™ Recombinant Rabbit Anti-NOTCH1 Monoclonal Antibody (DS2473AB) | WB, IHC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0078-YC-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone OMP-52M51); scFv Fragment | IHC | Mouse scFv |
| NS-060CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6); scFv Fragment | FC, IF, ELISA | Mouse scFv |
| NS-061CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10); scFv Fragment | FC, IF, ELISA | Mouse scFv |
| NS-062CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11); scFv Fragment | FC, IF, ELISA | Mouse scFv |
| HPAB-0681-WJ-S(P) | Human Anti-NOTCH1 Recombinant Antibody (clone h52M51); scFv Fragment | ELISA, WB | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-060CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6) | FC, IF, ELISA, Inhib, FuncS | Mouse IgG1 |
| NS-061CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10) | FC, IF, ELISA | Mouse IgG1 |
| NS-062CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11) | FC, IF, ELISA, Inhib | Mouse IgG2b |
| NS-063CN-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11); Fab Fragment | FC, IF, ELISA | Mouse Fab |
| NS-063CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11); scFv Fragment | FC, IF, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H11 | Afuco™ Anti-NOTCH1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H11) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC79 | Rabbit Anti-NOTCH1 Antibody (VS-0924-YC79) - Cancer Stem Cell Marker | IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY345 | Mouse Anti-NHP NOTCH1 Recombinant Antibody (clone mN1A) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC828 | CytoStream™ Rabbit Anti-NOTCH1 Recombinant Antibody (VS13-YC828) | WB, ICC, IF, IHC-P, IP, FC | Rabbit IgG |
| VS13-YC829 | CytoStream™ Rabbit Anti-NOTCH1 Polyclonal Antibody (VS13-YC829) | WB, IHC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY159 | Human Anti-NOTCH1 scFv-Fc Chimera (VS-0425-FY159) | ELISA, Inhib, WB, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1506 | Anti-NOTCH1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4907 | Anti-Mouse NOTCH1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4906 | Anti-Human NOTCH1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC381 | Recombinant Anti-NOTCH1 Vesicular Antibody, EV Displayed (VS-0425-YC381) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC139 | Recombinant Anti-NOTCH1 (LBD domain x HD-LNR domain) Biparatopic Antibody, Tandem scFv (Clone hN1wc49 x Clone N1wc104) | ELISA | Tandem scFv |
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