Anti-Human NOTUM Recombinant Antibody (SC2.A106)
CAT#: TAB-565MZ
This human Notum neutralizing monoclonal antibody is able to block the Notum activity and impairs Notum mediated proliferation. It dose not inhibit the activity of murine or macaque Notum despite showing cross reactivity with murine Notum.
Published Data
Gene Expression
FuncS
Figure 1 are graphical representations of a canonical Wnt3A assay as used to measure the effects of Notum modulators SC2.D2.2 and SC2.A106 (aka 10B3) on soluble Notum constructs Notum-His and Notum-hFc at various concentrations as normalized against uninhibited Wnt-induced luciferase activity.
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Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22851/1917_E7_5_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185269-NOTUM
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Specifications
- Host Species
- Mouse
- Specificity
- Human
- Species Reactivity
- Mouse
- Clone
- SC2.A106 (aka 10B3)
- Applications
- FuncS
- Related Disease
- Hyperproliferative disorders
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone SC2.A106 (aka 10B3)"
- CAT
- Product Name
See other products for "NOTUM"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-566MZ-S(P) | Anti-Human NOTUM Recombinant Antibody scFv Fragment (hSC2.D2.2) | ELISA | Humanized antibody |
| TAB-569MZ-S(P) | Human Anti-NOTUM Recombinant Antibody; scFv Fragment (TAB-569MZ-S(P)) | ELISA | Humanized scFv |
| TAB-566MZ-F(E) | Anti-Human NOTUM Recombinant Antibody Fab Fragment (hSC2.D2.2) | ELISA | Humanized antibody |
| TAB-569MZ-F(E) | Human Anti-NOTUM Recombinant Antibody; Fab Fragment (TAB-569MZ-F(E)) | ELISA | Humanized Fab |
| TAB-570MZ-F(E) | Human Anti-NOTUM Recombinant Antibody; Fab Fragment (TAB-570MZ-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC236 | Recombinant Anti-NOTUM Eliminating Antibody, pH-Sensitive (SC2.D2.2 var.) | Antigen-Sweeping In Vivo. | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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