Recombinant Human Anti-NRR1 Antibody (CAT#: PABX-152)
Anti-NRR1 antibody is a Human antibody of IgG1 class that binds to an NRR1. It developed From human phage antibody libraries with synthetic diversities in the selected complementary determining regions (H1, H2, H3, L3), mimicking the natural diversity of the human IgG repertoire.
Specific Inquiry
Figure 1 Anti-NRR1 is an anti-angiogenic agent that inhibits tumour growth.
a, Mouse neonate retinal assay for endothelial cell sprouting and angiogenesis. Retinal vasculature from mouse neonates treated with the indicated antibodies was visualized following isolectin perfusion. Top panels, scale bar 51mm. Bottom panels, scale bar 50.2mm.
Wu, Y., Cain-Hom, C., Choy, L., Hagenbeek, T. J., de Leon, G. P., Chen, Y., ... & Schahin-Reed, D. (2010). Therapeutic antibody targeting of individual Notch receptors. Nature, 464(7291), 1052.
Figure 2 Selective antibody blocking of Notch1 or Notch2 avoids severe goblet cell metaplasia associated with pan-Notch inhibition.
Immunohistochemical analyses of small intestines, using Alcian blue for mucin to mark secretory goblet cells, anti-Ki-67 staining for proliferation, anti-Hes1 staining for expression of a Notch pathway target, and lysozyme for Paneth cells.
Wu, Y., Cain-Hom, C., Choy, L., Hagenbeek, T. J., de Leon, G. P., Chen, Y., ... & Schahin-Reed, D. (2010). Therapeutic antibody targeting of individual Notch receptors. Nature, 464(7291), 1052.
Figure 3 Anti-NRR1 function as receptor-specific inhibitors in vivo.
Thymus or spleen cells frommice treated with the indicated reagents were harvested for flow cytometry ofCD41/CD81 T cells.
Wu, Y., Cain-Hom, C., Choy, L., Hagenbeek, T. J., de Leon, G. P., Chen, Y., ... & Schahin-Reed, D. (2010). Therapeutic antibody targeting of individual Notch receptors. Nature, 464(7291), 1052.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native Human NRR1
- Species Reactivity
- Human
- Applications
- ELISA 1:10000-1:20000
Neut (assay dependent)
FuncS (assay dependent)
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- NOTCH1; notch 1; hN1; AOS5; TAN1; AOVD1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated; translocation-associated notch protein TAN-1;
- Gene ID
- 4851
- UniProt ID
- P46531
Related Resources
Breast Cancer
Endocrine Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-660 | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment | ELISA | Human scFv |
| NS-060CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6); scFv Fragment | FC, IF, ELISA | Mouse scFv |
| NS-061CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10); scFv Fragment | FC, IF, ELISA | Mouse scFv |
| NS-062CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11); scFv Fragment | FC, IF, ELISA | Mouse scFv |
| HPAB-AP750-YC-S(P) | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133); scFv Fragment | ELISA, FC | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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